{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:47:45Z","timestamp":1791406065634,"version":"4.3.3"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2006,8,1]]},"DOI":"10.1021\/jm060449o","type":"journal-article","created":{"date-parts":[[2006,7,28]],"date-time":"2006-07-28T09:00:30Z","timestamp":1154077230000},"page":"5316-5323","source":"Crossref","is-referenced-by-count":46,"title":["Replacement of the Metabolically Labile Methyl Esters in the Alkenyldiarylmethane Series of Non-Nucleoside Reverse Transcriptase Inhibitors with Isoxazolone, Isoxazole, Oxazolone, or Cyano Substituents"],"prefix":"10.1021","volume":"49","author":[{"given":"Bo-Liang","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, ImQuest BioSciences, 7340 Executive Way, Suite R, Frederick, Maryland 21704, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, ImQuest BioSciences, 7340 Executive Way, Suite R, Frederick, Maryland 21704, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Buckheit,","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, ImQuest BioSciences, 7340 Executive Way, Suite R, Frederick, Maryland 21704, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pannecouque","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, ImQuest BioSciences, 7340 Executive Way, Suite R, Frederick, Maryland 21704, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"De Clercq","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, ImQuest BioSciences, 7340 Executive Way, Suite R, Frederick, Maryland 21704, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cushman","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, ImQuest BioSciences, 7340 Executive Way, Suite R, Frederick, Maryland 21704, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,7,28]]},"reference":[{"key":"jm060449ob00001\/jm060449ob00001_1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0969-2126(96)00091-3","volume":"4","author":"Hsiou Y.","year":"1996","journal-title":"Structure (London)"},{"key":"jm060449ob00002\/jm060449ob00002_1","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1126\/science.1377403","volume":"256","author":"Kohlstaedt L. A.","year":"1992","journal-title":"Science"},{"key":"jm060449ob00003\/jm060449ob00003_1","first-page":"1100","volume":"264","author":"Das K.","year":"1996","journal-title":"J. Mol. Biol."},{"key":"jm060449ob00004\/jm060449ob00004_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0969-2126(01)00168-X","volume":"3","author":"Ding J.","year":"1995","journal-title":"Structure"},{"key":"jm060449ob00005\/jm060449ob00005_1","first-page":"302","volume":"2","author":"Ren J.","year":"1995","journal-title":"Nat. Struct. Biol."},{"key":"jm060449ob00006\/jm060449ob00006_1","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1073\/pnas.94.8.3984","volume":"94","author":"Esnouf R. M.","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm060449ob00007\/jm060449ob00007_1","first-page":"1094","volume":"8","author":"Ren J.","year":"2000","journal-title":"Structure"},{"key":"jm060449ob00008\/jm060449ob00008_1","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1046\/j.1432-1327.2002.02811.x","volume":"269","author":"Lindberg J.","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"jm060449ob00009\/jm060449ob00009_1","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1021\/jm0500323","volume":"48","author":"Himmel D. M.","year":"2005","journal-title":"J. Med. Chem."},{"key":"jm060449ob00010\/jm060449ob00010_1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1126\/science.282.5394.1669","volume":"282","author":"Huang H.","year":"1998","journal-title":"Science"},{"key":"jm060449ob00011\/jm060449ob00011_1","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1073\/pnas.90.13.6320","volume":"90","author":"Jacobo-Molina A.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm060449ob00012\/jm060449ob00012_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/cbdv.200490012","volume":"1","author":"De Clercq E","year":"2004","journal-title":"Chem. Biodiversity"},{"key":"jm060449ob00013\/jm060449ob00013_1","first-page":"308","volume":"2","author":"Esnouf R.","year":"1995","journal-title":"Nat. Struct. Biol."},{"key":"jm060449ob00014\/jm060449ob00014_1","first-page":"332","volume":"2","author":"Sluis-Cremer N.","year":"2004","journal-title":"HIV Res."},{"key":"jm060449ob00015\/jm060449ob00015_1","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.biocel.2004.02.026","volume":"36","author":"Domaoal R. A.","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"jm060449ob00016\/jm060449ob00016_1","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1021\/jm990343b","volume":"42","author":"Casimiro-Garcia A.","year":"1999","journal-title":"J. Med. Chem."},{"key":"jm060449ob00016\/jm060449ob00016_2","first-page":"3162","volume":"47","author":"Silvestri M. A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm060449ob00017\/jm060449ob00017_1","first-page":"6155","volume":"48","author":"Deng B.-L.","year":"2005","journal-title":"J. Med. Chem."},{"key":"jm060449ob00018\/jm060449ob00018_1","first-page":"2374","volume":"14","author":"Deng B.-L.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"jm060449ob00019\/jm060449ob00019_1","first-page":"961","volume":"13","author":"Masuda N.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"jm060449ob00020\/jm060449ob00020_1","first-page":"1882","volume":"44","author":"Chan J. H.","year":"2001","journal-title":"J. Med. Chem."},{"key":"jm060449ob00021\/jm060449ob00021_1","first-page":"2719","volume":"126","author":"Rodr\u00edguez-Barrios F.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"jm060449ob00022\/jm060449ob00022_1","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1021\/jm049162m","volume":"48","author":"Sciabola S.","year":"2005","journal-title":"J. Med. Chem."},{"key":"jm060449ob00023\/jm060449ob00023_1","first-page":"1182","volume":"47","author":"Chan J. H.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm060449ob00024\/jm060449ob00024_1","first-page":"2234","volume":"11","author":"Ludovici D. W.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm060449ob00025\/jm060449ob00025_1","first-page":"2239","volume":"11","author":"Ludovici D. W.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm060449ob00026\/jm060449ob00026_1","first-page":"2560","volume":"47","author":"Das K.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm060449ob00027\/jm060449ob00027_1","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1021\/jm040829e","volume":"48","author":"Heeres J.","year":"2005","journal-title":"J. Med. Chem."},{"key":"jm060449ob00028\/jm060449ob00028_1","first-page":"1909","volume":"48","author":"Janssen P. A. J.","year":"2005","journal-title":"J. Med. Chem."},{"key":"jm060449ob00029\/jm060449ob00029_1","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1021\/jm040838n","volume":"48","author":"Guillemont J.","year":"2005","journal-title":"J. Med. Chem."},{"key":"jm060449ob00030\/jm060449ob00030_1","first-page":"270","volume":"30","author":"Lenz S. M.","year":"1995","journal-title":"Eur. J. Med. Chem."},{"key":"jm060449ob00031\/jm060449ob00031_1","first-page":"4468","volume":"48","author":"Shi G. Q.","year":"2005","journal-title":"J. Med. Chem."},{"key":"jm060449ob00032\/jm060449ob00032_1","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1021\/jm960082v","volume":"39","author":"Cushman M.","year":"1996","journal-title":"J. Med. Chem."},{"key":"jm060449ob00033\/jm060449ob00033_1","first-page":"438","volume":"33","author":"Rice W. G.","year":"1995","journal-title":"Adv. Pharmacol. (San Diego)"},{"key":"jm060449ob00034\/jm060449ob00034_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0166-0934(88)90134-6","volume":"20","author":"Pauwels R.","year":"1988","journal-title":"J. Virol. Methods"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm060449o","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T22:53:59Z","timestamp":1632437639000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm060449o"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,28]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2006,8,1]]}},"alternative-id":["10.1021\/jm060449o"],"URL":"https:\/\/doi.org\/10.1021\/jm060449o","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,28]]}}}