{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:17:29Z","timestamp":1792718249383,"version":"4.5.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2007,7,1]]},"DOI":"10.1021\/jm061324m","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T11:00:44Z","timestamp":1181214044000},"page":"3185-3193","source":"Crossref","is-referenced-by-count":54,"title":["Toward Improved Syntheses of Dendrimer-Based Magnetic Resonance Imaging Contrast Agents:\u2009 New Bifunctional Diethylenetriaminepentaacetic Acid Ligands and Nonaqueous Conjugation Chemistry"],"prefix":"10.1021","volume":"50","author":[{"given":"Heng","family":"Xu","sequence":"first","affiliation":[{"name":"Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, Research Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste A. S.","family":"Regino","sequence":"additional","affiliation":[{"name":"Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, Research Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelino","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, Research Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Koyama","sequence":"additional","affiliation":[{"name":"Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, Research Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, Research Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Choyke","sequence":"additional","affiliation":[{"name":"Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, Research Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Brechbiel","sequence":"additional","affiliation":[{"name":"Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, Research Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,6,7]]},"reference":[{"key":"jm061324mb00001\/jm061324mb00001_1","volume-title":"The chemistry of contrast agents in medical magnetic resonance imaging","author":"Merbach A. E.","year":"2001"},{"key":"jm061324mb00002\/jm061324mb00002_1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/cr00081a003","volume":"87","author":"Lauffer R. B","year":"1987","journal-title":"Chem. Rev."},{"key":"jm061324mb00003\/jm061324mb00003_1","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1021\/cr980440x","volume":"99","author":"Caravan P.","year":"1999","journal-title":"Chem. Rev."},{"key":"jm061324mb00004\/jm061324mb00004_1","first-page":"2286","volume":"57","author":"Kobayashi H.","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"jm061324mb00005\/jm061324mb00005_1","first-page":"470","volume":"186","author":"Comblin V.","year":"1999","journal-title":"Coordin. Chem. Rev."},{"key":"jm061324mb00006\/jm061324mb00006_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1021\/bc049817y","volume":"16","author":"Raymond K. N.","year":"2005","journal-title":"Bioconjugate Chem."},{"key":"jm061324mb00007\/jm061324mb00007_1","first-page":"8","volume":"31","author":"Weiner E. C.","year":"1994","journal-title":"Magn. Reson. Med."},{"key":"jm061324mb00008\/jm061324mb00008_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/mp050019e","volume":"2","author":"Venditto V. J.","year":"2005","journal-title":"Mol. Pharm."},{"key":"jm061324mb00009\/jm061324mb00009_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/bc00009a008","volume":"2","author":"Brechbiel M. W.","year":"1991","journal-title":"Bioconjugate Chem."},{"key":"jm061324mb00010\/jm061324mb00010_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/bc00014a004","volume":"3","author":"McMurry T. J.","year":"1992","journal-title":"Bioconjugate Chem."},{"key":"jm061324mb00011\/jm061324mb00011_1","first-page":"1934","volume":"5","author":"Wu C.","year":"1997","journal-title":"Bioorg. Med. Chem."},{"key":"jm061324mb00012\/jm061324mb00012_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrd1413","volume":"3","author":"Milenic D. E.","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"jm061324mb00013\/jm061324mb00013_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1162\/15353500200303100","volume":"2","author":"Kobayashi H.","year":"2003","journal-title":"Mol. Imaging"},{"key":"jm061324mb00014\/jm061324mb00014_1","first-page":"585","volume":"46","author":"Kobayashi H.","year":"2001","journal-title":"Magn. Reson. Med."},{"key":"jm061324mb00015\/jm061324mb00015_1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/jnci\/djh124","volume":"96","author":"Kobayashi H.","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"jm061324mb00016\/jm061324mb00016_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1021\/bc980091d","volume":"10","author":"Kobayashi H.","year":"1999","journal-title":"Bioconjugate Chem."},{"key":"jm061324mb00017\/jm061324mb00017_1","first-page":"454","volume":"4","author":"Wu C.","year":"1994","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm061324mb00018\/jm061324mb00018_1","doi-asserted-by":"crossref","unstructured":"Assony, S. J. The chemistry of thiocyanates; InOrganic Chemistry ofSulfur Compounds; Kharasch, N., Ed.; Pergamon:\u2009 Oxford, 1961; p 326.","DOI":"10.1016\/B978-1-4831-9982-5.50031-2"},{"key":"jm061324mb00019\/jm061324mb00019_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1021\/nl060765q","volume":"6","author":"Talanov V. S.","year":"2006","journal-title":"Nano Lett."},{"key":"jm061324mb00020\/jm061324mb00020_1","first-page":"200","volume":"9","author":"Bass L. A.","year":"1998","journal-title":"Bioconjugate Chem."},{"key":"jm061324mb00021\/jm061324mb00021_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0021-9673(97)00108-8","volume":"771","author":"Brechbiel M. W.","year":"1997","journal-title":"J. Chromatogr. A"},{"key":"jm061324mb00022\/jm061324mb00022_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.nucmedbio.2006.03.001","volume":"33","author":"Talanov V. S.","year":"2006","journal-title":"Nucl. Med. Biol."},{"key":"jm061324mb00023\/jm061324mb00023_1","first-page":"802","volume":"46","author":"Kobayashi H.","year":"2001","journal-title":"Magn. Reson. Med."},{"key":"jm061324mb00024\/jm061324mb00024_1","volume-title":"Applications","author":"Newkome G. R.","year":"2001"},{"key":"jm061324mb00025\/jm061324mb00025_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/anie.199001381","volume":"29","author":"Tomalia D. A.","year":"1990","journal-title":"Angew. Chem. Int. Ed."},{"key":"jm061324mb00026\/jm061324mb00026_1","first-page":"57","volume":"37","author":"Tomalia D. A","year":"2004","journal-title":"Aldrichimica Acta"},{"key":"jm061324mb00027\/jm061324mb00027_1","first-page":"324","volume":"30","author":"Tomalia D. A","year":"2005","journal-title":"Prog. Polym. Sci."},{"key":"jm061324mb00028\/jm061324mb00028_1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.addr.2005.09.018","volume":"57","author":"Svenson S.","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"jm061324mb00029\/jm061324mb00029_1","first-page":"247","volume-title":"Advances in Dendritic Macromolecules","author":"Weiner E.","year":"2002"},{"key":"jm061324mb00030\/jm061324mb00030_1","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1002\/pola.10301","volume":"40","author":"Tomalia D. A.","year":"2002","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"jm061324mb00031\/jm061324mb00031_1","first-page":"148","volume":"65","author":"Malika N.","year":"2000","journal-title":"J. Controlled Release"},{"key":"jm061324mb00032\/jm061324mb00032_1","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1073\/pnas.062684999","volume":"99","author":"Tomalia D. A.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm061324mb00033\/jm061324mb00033_1","doi-asserted-by":"crossref","first-page":"12169","DOI":"10.1021\/ja053008n","volume":"127","author":"Wolfenden M. L.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"jm061324mb00034\/jm061324mb00034_1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/1521-3765(20020301)8:5<1040::AID-CHEM1040>3.0.CO;2-D","volume":"8","author":"Nicolle G. M.","year":"2002","journal-title":"Chem. Eur. J."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm061324m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T23:49:41Z","timestamp":1679010581000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm061324m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,7]]},"references-count":34,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2007,7,1]]}},"alternative-id":["10.1021\/jm061324m"],"URL":"https:\/\/doi.org\/10.1021\/jm061324m","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,7]]}}}