{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:38:01Z","timestamp":1760852281304},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2007,7,1]]},"DOI":"10.1021\/jm070242a","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T14:09:07Z","timestamp":1182002947000},"page":"3340-3353","source":"Crossref","is-referenced-by-count":8,"title":["Improved Anti-Osteoporosis Potency and Reduced Endometrial Membrane Hyperplasia During Hormone Replacement Therapy with Estrogen\u2212RGD Peptide Conjugates"],"prefix":"10.1021","volume":"50","author":[{"given":"Yu","family":"Xiong","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China, College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100069, People's Republic of China, and C S Bio Company, 20 Kelly Court, Menlo Park, California 94025"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China, College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100069, People's Republic of China, and C S Bio Company, 20 Kelly Court, Menlo Park, California 94025"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China, College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100069, People's Republic of China, and C S Bio Company, 20 Kelly Court, Menlo Park, California 94025"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China, College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100069, People's Republic of China, and C S Bio Company, 20 Kelly Court, Menlo Park, California 94025"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China, College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100069, People's Republic of China, and C S Bio Company, 20 Kelly Court, Menlo Park, California 94025"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2007,6,16]]},"reference":[{"key":"jm070242ab00001\/jm070242ab00001_1","first-page":"82","volume":"12","author":"Davidson M.","year":"2002","journal-title":"Clin. Rev."},{"key":"jm070242ab00002\/jm070242ab00002_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.amjmed.2005.10.048","volume":"119","author":"Amin","year":"2006","journal-title":"Am. J. Med."},{"key":"jm070242ab00003\/jm070242ab00003_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0002-9378(99)70285-1","volume":"180","author":"Spencer C. P.","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"jm070242ab00004\/jm070242ab00004_1","volume-title":"Selective estrogen receptor modulators:\u2009 The ideal estrogen replacement","author":"Michael J. S.","year":"2001"},{"key":"jm070242ab00005\/jm070242ab00005_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1056\/NEJM199802193380801","volume":"338","author":"Hosking D.","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"jm070242ab00006\/jm070242ab00006_1","first-page":"63","volume":"20","author":"Stampter M.","year":"1991","journal-title":"Prev. Med."},{"key":"jm070242ab00007\/jm070242ab00007_1","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1136\/bmj.316.7148.1863","volume":"316","author":"Michealsson K.","year":"1998","journal-title":"Br. Med. J."},{"key":"jm070242ab00008\/jm070242ab00008_1","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1056\/NEJM199506153322401","volume":"332","author":"Colditz G. A.","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"jm070242ab00009\/jm070242ab00009_1","first-page":"1827","volume":"161","author":"Mishell D. J","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"jm070242ab00010\/jm070242ab00010_1","first-page":"755","volume":"31","author":"Witt D. M.","year":"1997","journal-title":"Ann. Pharmaeother."},{"key":"jm070242ab00011\/jm070242ab00011_1","first-page":"934","volume":"155","author":"Josse R. G","year":"1996","journal-title":"Can. Med. Assoc. J."},{"key":"jm070242ab00012\/jm070242ab00012_1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0039-128X(01)00112-X","volume":"66","author":"Wang C.","year":"2001","journal-title":"Steroids"},{"key":"jm070242ab00013\/jm070242ab00013_1","first-page":"4421","volume":"12","author":"Wang C.","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"jm070242ab00014\/jm070242ab00014_1","first-page":"146","volume":"13","author":"Wang C.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm070242ab00015\/jm070242ab00015_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1615\/CritRevEukarGeneExpr.v8.i2.20","volume":"8","author":"Oursler M. J","year":"1998","journal-title":"Crit. Rev. Eukaryotic Gene Expression"},{"key":"jm070242ab00016\/jm070242ab00016_1","volume-title":"Am.","volume":"1994","author":"Majeska K. J."},{"key":"jm070242ab00017\/jm070242ab00017_1","first-page":"603","volume":"107","author":"Zang X. Y.","year":"1994","journal-title":"Chin. Med. J."},{"key":"jm070242ab00018\/jm070242ab00018_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0014-4827(91)90386-9","volume":"195","author":"Horton M. A.","year":"1991","journal-title":"Exp. Cell Res."},{"key":"jm070242ab00019\/jm070242ab00019_1","doi-asserted-by":"crossref","first-page":"133s","DOI":"10.1016\/8756-3282(95)97353-H","volume":"17","author":"Thompson D. D.","year":"1995","journal-title":"Bone"},{"key":"jm070242ab00020\/jm070242ab00020_1","volume-title":"Effect of erythroblust calcium ion concentration on the micronucleus test:\u2009 Mutation research\/environmental mutagenesis and related subjects","author":"Suzuki Y.","year":"1996"},{"key":"jm070242ab00021\/jm070242ab00021_1","first-page":"16","volume":"12","author":"Titov V. N.","year":"1991","journal-title":"Lab. Delo."},{"key":"jm070242ab00022\/jm070242ab00022_1","first-page":"293","volume":"168","author":"Wright D. S.","year":"1988","journal-title":"Anal. Biochem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm070242a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T23:55:51Z","timestamp":1679010951000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm070242a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,16]]},"references-count":22,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2007,7,1]]}},"alternative-id":["10.1021\/jm070242a"],"URL":"https:\/\/doi.org\/10.1021\/jm070242a","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,16]]}}}