{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:27:03Z","timestamp":1791685623392,"version":"4.3.4"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2010,7,22]]},"DOI":"10.1021\/jm100499s","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T12:35:53Z","timestamp":1276778153000},"page":"5281-5289","source":"Crossref","is-referenced-by-count":88,"title":["Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann\u2212Pick Type C Disease Therapeutics"],"prefix":"10.1021","volume":"53","author":[{"given":"Anton I.","family":"Rosenbaum","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey C.","family":"Cosner","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Mariani","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick R.","family":"Maxfield","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Wiest","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Helquist","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,6,17]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbalip.2004.08.014","volume":"1685","author":"Sturley S. L.","year":"2004","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbalip.2004.08.009","volume":"1685","author":"Mukherjee S.","year":"2004","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"key":"ref1\/cit1c","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature04399","volume":"438","author":"Maxfield F. R.","year":"2005","journal-title":"Nature"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/B978-012369437-9\/50025-6","volume-title":"Protein Trafficking in Neurons","author":"Cataldo A. M.","year":"2007"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1083\/jcb.108.5.1625","volume":"108","author":"Liscum L.","year":"1989","journal-title":"J. Cell Biol."},{"key":"ref4\/cit4","first-page":"61","volume":"98","author":"Patterson M. C.","year":"2009","journal-title":"Mol. Genet. Metab."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1073\/pnas.0810895106","volume":"106","author":"Liu B.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1073\/pnas.0812934106","volume":"106","author":"Sturley S. L.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref5\/cit5c","doi-asserted-by":"crossref","first-page":"19316","DOI":"10.1073\/pnas.0910916106","volume":"106","author":"Abi-Mosleh L.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref5\/cit5d","doi-asserted-by":"crossref","first-page":"e6951","DOI":"10.1371\/journal.pone.0006951","volume":"4","author":"Davidson C. D.","year":"2009","journal-title":"PLoS One"},{"key":"ref5\/cit5e","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1073\/pnas.0914309107","volume":"107","author":"Rosenbaum A. I.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1016\/S0021-9258(19)40786-2","volume":"250","author":"Goldstein J. L.","year":"1975","journal-title":"J. Biol. Chem."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0076-6879(83)98152-1","volume":"98","author":"Goldstein J. L.","year":"1983","journal-title":"Methods Enzymol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bbalip.2009.03.002","volume":"1791","author":"Mesmin B.","year":"2009","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/S0021-9258(18)69086-6","volume":"263","author":"Sokol J.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1194\/jlr.M000257","volume":"51","author":"Liu B.","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1194\/jlr.M500388-JLR200","volume":"47","author":"Pipalia N. H.","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1021\/jm900707n","volume":"52","author":"Cosner C. C.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bbalip.2009.08.005","volume":"1791","author":"Rosenbaum A. I.","year":"2009","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/oxfordjournals.jbchem.a134399","volume":"94","author":"Imanaka T.","year":"1983","journal-title":"J. Biochem."},{"key":"ref14\/cit14","first-page":"297","volume":"13","author":"Koutentis P. A.","year":"2004","journal-title":"Sci. Synth."},{"key":"ref15\/cit15a","unstructured":"aBymaster, F. P.; Shannon, H. E.Combination Therapy for Treatment of Psychoses. U.S. Patent 2004\/0023951 A1, February 5, 2004."},{"key":"ref15\/cit15b","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/S0960-894X(00)80072-4","volume":"4","author":"Quimby S. J.","year":"1994","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0021-9258(18)64619-8","volume":"235","author":"Wilson I. B.","year":"1960","journal-title":"J. Biol. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1021\/bi020016x","volume":"41","author":"Bar-On P.","year":"2002","journal-title":"Biochemistry"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1021\/jm800564y","volume":"51","author":"Carolan C. G.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3987\/R-1986-04-1131","volume":"24","author":"De Munno A.","year":"1986","journal-title":"Heterocycles"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1021\/cm00041a014","volume":"6","author":"Kouvetakis J.","year":"1994","journal-title":"Chem. Mater."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1016\/j.tetlet.2006.09.102","volume":"47","author":"Merschaert A.","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"ref22\/cit22a","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1021\/jm0301235","volume":"46","author":"Cao Y.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22b","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0960-894X(01)00151-2","volume":"11","author":"Sabb A. L.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref22\/cit22c","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bmcl.2009.01.027","volume":"19","author":"Biju P.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0021-9258(18)64204-8","volume":"236","author":"Wilson I. B.","year":"1961","journal-title":"J. Biol. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1039\/a606020j","author":"Crampton M. R.","year":"1997","journal-title":"J. Chem. Res., Synop."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1093\/hmg\/10.16.1639","volume":"10","author":"Du H.","year":"2001","journal-title":"Hum. Mol. Genet."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm100499s","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T12:12:04Z","timestamp":1680610324000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm100499s"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,17]]},"references-count":35,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,7,22]]}},"alternative-id":["10.1021\/jm100499s"],"URL":"https:\/\/doi.org\/10.1021\/jm100499s","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,17]]}}}