{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:21:58Z","timestamp":1790482918037,"version":"4.1.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2010,8,26]]},"DOI":"10.1021\/jm100505n","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T11:44:35Z","timestamp":1280490275000},"page":"5979-6002","source":"Crossref","is-referenced-by-count":92,"title":["Discovery of (3\n                    <i>S<\/i>\n                    ,3a\n                    <i>R<\/i>\n                    )-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2\n                    <i>H<\/i>\n                    -benzo[\n                    <i>g<\/i>\n                    ]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy"],"prefix":"10.1021","volume":"53","author":[{"given":"Marvin J.","family":"Meyers","sequence":"first","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela B.","family":"Arhancet","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Hockerman","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Chen","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Long","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Mahoney","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Rico","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.","family":"Garland","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James. R.","family":"Blinn","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe T.","family":"Collins","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtian","family":"Yang","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horng-Chih","family":"Huang","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F.","family":"McGee","sequence":"additional","affiliation":[{"name":"Albany Molecular Research, Inc., 26 Corporate Circle, Albany, New York 12203"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"Wendling","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D.","family":"Dietz","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Payne","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Homer","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia I.","family":"Heron","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Reitz","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,7,30]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/HJH.0b013e328010775f","volume":"25","author":"Martiniuk A. L.","year":"2007","journal-title":"J. Hypertens."},{"issue":"3","key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/01.HYP.25.3.305","volume":"25","author":"Burt V. L.","year":"1995","journal-title":"Hypertension"},{"key":"ref1\/cit1c","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jama.290.2.199","volume":"290","author":"Hajjar I.","year":"2003","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/bmj.326.7380.61","volume":"326","author":"Williams B.","year":"2003","journal-title":"Br. Med. J."},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"Chobanian A. V.","year":"2003","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S1043-2760(00)00270-8","volume":"11","author":"Young M.","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1021\/jm0503704","volume":"48","author":"Voets M.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1021\/jm060055x","volume":"49","author":"Voets M.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1021\/jm800377h","volume":"51","author":"Heim R.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4d","doi-asserted-by":"crossref","first-page":"6138","DOI":"10.1021\/jm800683c","volume":"51","author":"Lucas S.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4e","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.1021\/jm800888q","volume":"51","author":"Lucas S.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4f","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2009.04.013","volume":"116","author":"Ries C.","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0895-7061(02)02957-6","volume":"15","author":"Weinberger M. H.","year":"2002","journal-title":"Am. J. Hypertens."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","volume":"348","author":"Pitt B.","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref5\/cit5c","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2174\/1389557054553811","volume":"5","author":"Hu X.","year":"2005","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1681\/ASN.2009070737","volume":"20","author":"Mehdi U. F.","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1440-1681.2006.04354.x","volume":"33","author":"Williams G. H.","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0022-4731(89)90169-6","volume":"32","author":"De Gasparo M.","year":"1989","journal-title":"J. Steroid Biochem."},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1517\/13543776.17.1.17","volume":"17","author":"Meyers M. J.","year":"2007","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1021\/jm701186z","volume":"50","author":"Bell M. G.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/HYPERTENSIONAHA.107.103580","volume":"51","author":"Dietz J. D.","year":"2008","journal-title":"Hypertension"},{"key":"ref9\/cit9b","unstructured":"bFukumoto, S.; Ohra, T.; Sakamoto, J.Aldosterone Receptor Antagonists. WO2005\/097118, October 20, 2005."},{"key":"ref9\/cit9c","unstructured":"cB\u00e4rfacker, L.; Kolkhof, P.; Schlemmer, K.H.; Grosser, R.; Nitsche, A.; Klein, M.; M\u00fcnter, K.; Albrecht-K\u00fcpper, B.; Hartmann, E.Substituted 4-Aryl-1,4-dihydro-1,6-naphthyridinamides and Use Thereof. WO2008\/104306, September 4, 2008."},{"key":"ref9\/cit9d","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1021\/jm1002827","volume":"53","author":"Arhancet G. B.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9e","doi-asserted-by":"publisher","DOI":"10.1021\/jm100506y"},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1021\/jm0613976","volume":"50","author":"Zhang X.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bmcl.2006.10.035","volume":"17","author":"Zhang X.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref10\/cit10c","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1016\/j.bmcl.2005.05.001","volume":"15","author":"Jones D. G.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref10\/cit10d","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1021\/jm00025a004","volume":"38","author":"Combs D. W.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref10\/cit10e","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0968-0896(00)00226-1","volume":"9","author":"Stauffer S. R.","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1084\/jem.115.6.1173","volume":"115","author":"Dahl L. K.","year":"1962","journal-title":"J. Exp. Med."},{"key":"ref11\/cit11b","unstructured":"bMeyers, M. J.; Arhancet, G. B.; Chen, X.; Hockerman, S. L.; Long, S. A.; Mahoney, M. W.; Reitz, D. B.; Rico, J. G.Pyrazoline Compounds as Mineralocorticoid Receptor Antagonists. WO 2008\/053300, May 8, 2008."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1210\/me.2004-0537","volume":"19","author":"Hultman M. L.","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1016\/S0040-4020(98)00137-9","volume":"54","author":"Powers D. G.","year":"1998","journal-title":"Tetrahedron"},{"key":"ref14\/cit14a","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1016\/S0040-4020(01)90482-X","volume":"50","author":"Bach K. K.","year":"1994","journal-title":"Tetrahedron"},{"key":"ref14\/cit14b","volume-title":"1,3-Dipolar Cycloaddition Chemistry","author":"Padwa A.","year":"1984"},{"key":"ref14\/cit14c","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/cc0601175","volume":"9","author":"Manyem S.","year":"2007","journal-title":"J. Comb. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1016\/S0040-4039(99)00227-0","volume":"40","author":"Foti F.","year":"1999","journal-title":"Tetrahedron Lett."},{"key":"ref16\/cit16","unstructured":"Freudenberger, J. H.; Lahm, G. P.; Selby, T. P.; Stevenson, T. M.Substituted Dihydro 3-Halo-1\n                      H\n                      -pyrazole-5-carboxylates Their Preparation and Use. WO 03\/016283, February 27, 2003."},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1021\/jm060379l","volume":"17","author":"Jamieson C.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2174\/138955705774933338","volume":"5","author":"Jalaie M.","year":"2005","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref17\/cit17c","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1021\/jm0700565","volume":"50","author":"Singleton D. H.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref17\/cit17d","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1124\/jpet.302.1.320","volume":"302","author":"Volberg W. A.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molcel.2005.06.026","volume":"19","author":"Li Y.","year":"2005","journal-title":"Mol. Cell"},{"key":"ref19\/cit19a","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.1021\/jm061101w","volume":"49","author":"Sun C.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1021\/jm801583j","volume":"52","author":"Nirschl A. A.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19c","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1016\/j.bmcl.2008.09.002","volume":"18","author":"Bohl C. E.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref19\/cit19d","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/en.2006-0843","volume":"148","author":"Ostrowski J.","year":"2007","journal-title":"Endocrinolgy"},{"key":"ref19\/cit19e","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1073\/pnas.0500381102","volume":"102","author":"Bohl C. E.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref19\/cit19f","doi-asserted-by":"crossref","first-page":"28468","DOI":"10.1074\/jbc.M504144200","volume":"280","author":"Zhang Z.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"31283","DOI":"10.1074\/jbc.M504098200","volume":"280","author":"Bledsoe R. K.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1021\/jm00125a013","volume":"32","author":"Collins P. W.","year":"1989","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/jo00084a050","volume":"59","author":"Koch K.","year":"1994","journal-title":"J. Org. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1111\/j.1523-1755.2005.00669.x","volume":"68","author":"Rodr\u00edguez-Iturbe B.","year":"2005","journal-title":"Kidney Int."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm050540c","volume":"49","author":"Sherman W.","year":"2006","journal-title":"J. Med. Chem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm100505n","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T11:52:09Z","timestamp":1680695529000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm100505n"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,30]]},"references-count":55,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2010,8,26]]}},"alternative-id":["10.1021\/jm100505n"],"URL":"https:\/\/doi.org\/10.1021\/jm100505n","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,30]]}}}