{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:58:46Z","timestamp":1760853526219},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2011,4,28]]},"DOI":"10.1021\/jm200020a","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T16:09:11Z","timestamp":1301414951000},"page":"2924-2932","source":"Crossref","is-referenced-by-count":15,"title":["Further Structure\u2212Activity Relationship Studies on 4-((((3<i>S<\/i>,6<i>S<\/i>)-6-Benzhydryltetrahydro-2<i>H<\/i>-pyran-3-yl)amino)methyl)phenol: Identification of Compounds with Triple Uptake Inhibitory Activity as Potential Antidepressant Agents"],"prefix":"10.1021","volume":"54","author":[{"given":"Bhaskar","family":"Gopishetty","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Hazeldine","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumava","family":"Santra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyan","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solav","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Reith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloke","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2011,3,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","volume":"289","author":"Kessler R. C.","year":"2003","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/3218","volume":"4","author":"Lopez A. D.","year":"1998","journal-title":"Nat. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1176\/ajp.151.9.1312","volume":"151","author":"Dilsaver S. C.","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1176\/ajp.153.5.674","volume":"153","author":"Strakowski S. M.","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0006-3223(98)00068-7","volume":"44","author":"Nemeroff C. B.","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/sj.mp.4000728","volume":"5","author":"Iversen L.","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/026988119801200201","volume":"12","author":"Schloss P.","year":"1998","journal-title":"J. Psychopharmacol."},{"key":"ref8\/cit8","first-page":"39","volume":"51","author":"Nierenberg A. A.","year":"1990","journal-title":"J. Clin. Psychiatry"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/sj.npp.1300405","volume":"29","author":"Nierenberg A. A.","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0014-2999(00)00566-5","volume":"405","author":"D\u2019Aquila P. S.","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.euroneuro.2005.12.002","volume":"16","author":"Papakostas G. I.","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4088\/JCP.v65n0110","volume":"65","author":"Clayton A. H.","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.4088\/JCP.v65n0806","volume":"65","author":"Damsa C.","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-2999(03)01310-4","volume":"461","author":"Skolnick P.","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2006.10.004","volume":"555","author":"Shaw A. M.","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/187152707780363285","volume":"6","author":"Skolnick P.","year":"2007","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/jpet.108.143610","volume":"327","author":"Liang Y.","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1527-3458.2006.00123.x","volume":"12","author":"Skolnick P.","year":"2006","journal-title":"CNS Drug Rev."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/S0960-894X(01)00443-7","volume":"11","author":"Dutta A. K.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/jm010316x","volume":"45","author":"Dutta A. K.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1021\/jm020275k","volume":"46","author":"Ghorai S. K.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2003.08.060","volume":"479","author":"Dutta A. K.","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0960-894X(03)00169-0","volume":"13","author":"Zhang S.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1021\/jm049796t","volume":"47","author":"Kolhatkar R.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1016\/j.bmc.2004.07.069","volume":"12","author":"Zhang S.","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1021\/jm049021k","volume":"48","author":"Zhang S.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1021\/jm0601699","volume":"49","author":"Zhang S.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2008.05.008","volume":"589","author":"Dutta A. K.","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1021\/jm990291q","volume":"42","author":"Lewis D. B.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"Porsolt R. D.","year":"1977","journal-title":"Nature"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","volume":"23","author":"Cryan J. F.","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng Y.","year":"1973","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm200020a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T07:32:58Z","timestamp":1682580778000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm200020a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,29]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,4,28]]}},"alternative-id":["10.1021\/jm200020a"],"URL":"https:\/\/doi.org\/10.1021\/jm200020a","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,29]]}}}