{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:21:08Z","timestamp":1780539668552,"version":"3.54.1"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2011,10,27]]},"DOI":"10.1021\/jm200770f","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T20:33:06Z","timestamp":1317069186000},"page":"7165-7175","source":"Crossref","is-referenced-by-count":27,"title":["Synthesis and Structure\u2013Activity Relationship Studies in Translocator Protein Ligands Based on a Pyrazolo[3,4-<i>b<\/i>]quinoline Scaffold"],"prefix":"10.1021","volume":"54","author":[{"given":"Andrea","family":"Cappelli","sequence":"first","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bini","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Valenti","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germano","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Paolino","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Anzini","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Vomero","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica, Universit\u00e0 degli Studi di Siena, Via A. Moro, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Giordani","sequence":"additional","affiliation":[{"name":"Rottapharm SpA, Via Valosa di Sopra 7, 20052 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Piero","family":"Stasi","sequence":"additional","affiliation":[{"name":"Rottapharm SpA, Via Valosa di Sopra 7, 20052 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Makovec","sequence":"additional","affiliation":[{"name":"Rottapharm SpA, Via Valosa di Sopra 7, 20052 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ghelardini","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacologia Preclinica e Clinica \u201cM. Aiazzi Mancini\u201d, Universit\u00e0 degli Studi di Firenze,Viale G. Pieraccini 6, 50139 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Di Cesare Mannelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacologia Preclinica e Clinica \u201cM. Aiazzi Mancini\u201d, Universit\u00e0 degli Studi di Firenze,Viale G. Pieraccini 6, 50139 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Concas","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Sperimentale \u201cB. Loddo\u201d, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS 554 (km 4.500), 09042 Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Porcu","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Sperimentale \u201cB. Loddo\u201d, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS 554 (km 4.500), 09042 Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Biggio","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Sperimentale \u201cB. Loddo\u201d, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS 554 (km 4.500), 09042 Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,9,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tips.2006.06.005","volume":"27","author":"Papadopoulos V.","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0021-9258(17)36131-8","volume":"261","author":"Anholt R.","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0039-128X(03)00101-6","volume":"68","author":"Lacapere J.-J.","year":"2003","journal-title":"Steroids"},{"key":"ref3\/cit3","first-page":"831","volume":"59","author":"Hardwick M.","year":"1999","journal-title":"Cancer Res."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(88)90834-5","volume":"152","author":"Olson J. M.","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.2174\/138161207781368710","volume":"13","author":"Veenman L.","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.pharmthera.2005.09.007","volume":"110","author":"Veenman L.","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"ref5\/cit5c","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuroscience.2005.05.063","volume":"138","author":"Papadopoulos V.","year":"2006","journal-title":"Neuroscience"},{"key":"ref5\/cit5d","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0197-0186(01)00118-8","volume":"40","author":"Casellas P.","year":"2002","journal-title":"Neurochem. Int."},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2007.12.004","volume":"118","author":"Chen M. K.","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.expneurol.2009.04.016","volume":"219","author":"Papadopoulos V.","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0031-6997(24)01424-8","volume":"51","author":"Gavish M.","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"ref7\/cit7b","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.euroneuro.2007.10.003","volume":"18","author":"Chelli B.","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref7\/cit7c","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00213-005-2247-x","volume":"181","author":"Pini S.","year":"2005","journal-title":"Psychopharmacology"},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0022-3565(25)10942-7","volume":"262","author":"Romeo E.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1021\/jm00072a010","volume":"36","author":"Kozikowski A. P.","year":"1993","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1021\/jm8003224","volume":"51","author":"Da Settimo F.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1016\/j.bmc.2005.05.015","volume":"13","author":"Selleri S.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1124\/jpet.301.3.1067","volume":"301","author":"Ferzaz B.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.bbrc.2003.09.079","volume":"310","author":"Vin V.","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref12\/cit12a","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1175055","volume":"325","author":"Rupprecht R.","year":"2009","journal-title":"Science"},{"key":"ref12\/cit12b","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.bjp.0705681","volume":"142","author":"Kita A.","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref13\/cit13a","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1021\/jm960325j","volume":"39","author":"Anzini M.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13b","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1016\/j.bmc.2007.06.044","volume":"16","author":"Cappelli A.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0968-0896(01)00332-7","volume":"10","author":"Cappelli A.","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"ref15\/cit15","unstructured":"Sheldrick, G. M.SHELXS-97, Release 97\u20132, A Program for Automatic Solution of Crystal Structures;University of G\u00f6ttingen:G\u00f6ttingen, Germany, 1997."},{"key":"ref16\/cit16","unstructured":"Sheldrick, G. M.SHELXL-97, Release 97\u20132, A Program for Crystal Structure Refinement;University of G\u00f6ttingen:G\u00f6ttingen, Germany, 1997."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"Bennett G. J.","year":"1988","journal-title":"Pain"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1476-5381.1988.tb10310.x","volume":"93","author":"Leighton G. E.","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/BF02245629","volume":"122","author":"Walsh D. M.","year":"1995","journal-title":"Psychopharmacology"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm200770f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:23:24Z","timestamp":1741746204000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm200770f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,26]]},"references-count":30,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2011,10,27]]}},"alternative-id":["10.1021\/jm200770f"],"URL":"https:\/\/doi.org\/10.1021\/jm200770f","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,26]]}}}