{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:28:12Z","timestamp":1791142092244,"version":"4.1.0"},"reference-count":77,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2012,1,12]]},"DOI":"10.1021\/jm201105a","type":"journal-article","created":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T16:43:32Z","timestamp":1322585012000},"page":"153-168","source":"Crossref","is-referenced-by-count":70,"title":["\u03b1-Aryl-<i>N<\/i>-alkyl Nitrones, as Potential Agents for Stroke Treatment: Synthesis, Theoretical Calculations, Antioxidant, Anti-inflammatory, Neuroprotective, and Brain\u2013Blood Barrier Permeability Properties"],"prefix":"10.1021","volume":"55","author":[{"given":"Mourad","family":"Chioua","sequence":"first","affiliation":[{"name":"Laboratorio de Radicales Libres y Qu\u00edmica Computacional, Instituto de Qu\u00edmica Org\u00e1nica General (CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sucunza","sequence":"additional","affiliation":[{"name":"Laboratorio de Radicales Libres y Qu\u00edmica Computacional, Instituto de Qu\u00edmica Org\u00e1nica General (CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Soriano","sequence":"additional","affiliation":[{"name":"Laboratorio de Radicales Libres y Qu\u00edmica Computacional, Instituto de Qu\u00edmica Org\u00e1nica General (CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Hadjipavlou-Litina","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Alc\u00e1zar","sequence":"additional","affiliation":[{"name":"Departamento Investigaci\u00f3n, IRYCIS, Hospital Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ayuso","sequence":"additional","affiliation":[{"name":"Departamento Investigaci\u00f3n, IRYCIS, Hospital Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Oset-Gasque","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular II, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n en Neuroqu\u00edmica (IUIN), Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Pilar","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular II, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Monjas","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Rodr\u00edguez-Franco","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Marco-Contelles","sequence":"additional","affiliation":[{"name":"Laboratorio de Radicales Libres y Qu\u00edmica Computacional, Instituto de Qu\u00edmica Org\u00e1nica General (CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelouahid","family":"Samadi","sequence":"additional","affiliation":[{"name":"Laboratorio de Radicales Libres y Qu\u00edmica Computacional, Instituto de Qu\u00edmica Org\u00e1nica General (CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.clineuro.2009.04.001","volume":"111","author":"Brouns R.","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref2\/cit2","first-page":"89","volume-title":"Cellular Antioxidant Defense Mechanisms","author":"Chan P. H.","year":"1988"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.freeradbiomed.2008.08.017","volume":"45","author":"Floyd R. A.","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00004647-199907000-00008","volume":"19","author":"Kuroda S.","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1161\/STROKEAHA.108.515957","volume":"39","author":"Macleod M. R.","year":"2008","journal-title":"Stroke"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2174\/0929867003374183","volume":"7","author":"Goldstein S.","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1016\/j.bmc.2009.04.004","volume":"17","author":"Dias A. G.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.1021\/jm8006432","volume":"51","author":"Porcal W.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1016\/j.bmc.2007.02.033","volume":"15","author":"Kim S.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1016\/j.bmcl.2005.04.043","volume":"15","author":"Balogh G. T.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1021\/ja011507s","volume":"124","author":"Becker D. A.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1021\/jm991154w","volume":"43","author":"Dhainaut A.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1016\/j.bmcl.2006.09.005","volume":"16","author":"Nakagawa H.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-5793(91)80194-8","volume":"280","author":"Kalyanaraman B.","year":"1991","journal-title":"FEBS Lett."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0167-4889(83)90115-5","volume":"762","author":"Hill H. A.","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.freeradbiomed.2005.05.003","volume":"39","author":"Margaill I.","year":"2005","journal-title":"Free. Radical Biol. Med."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0074-7742(08)60725-4","volume":"40","author":"Hensley K.","year":"1997","journal-title":"Int. Rev. Neurobiol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10715769509064014","volume":"23","author":"Chamulitrat W.","year":"1995","journal-title":"Free Radic. Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.bmc.2010.11.053","volume":"19","author":"Abdelouahid S.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.bmcl.2009.02.005","volume":"19","author":"Liu W.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1021\/jo00035a020","volume":"57","author":"Hinton R. D.","year":"1992","journal-title":"J. Org. Chem."},{"key":"ref22\/cit22","unstructured":"Waterbury, D.; Wood, P. L.; Khan, M. A.; Upasani, R. B.Use of aryl nitrone compounds in methods for treating neuropathic pain. PCT Int. Appl. WO 2002065993, 2002."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1359-6446(04)03065-X","volume":"9","author":"Pardridge W. M.","year":"2004","journal-title":"Drug Discovery Today"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1021\/jm991154w","volume":"43","author":"Dhainaut A.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.foodchem.2003.07.024","volume":"85","author":"Kulisic T.","year":"2004","journal-title":"Food Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1021\/jf9911242","volume":"48","author":"Liegeois C.","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-2999(01)01126-8","volume":"423","author":"Gornicki A.","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/jf030723c","volume":"53","author":"Huang D.","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref30\/cit30","unstructured":"C-QSAR Database;Biobyte Corp.:201 West 4th Street, Suite 204, Claremont CA 91711."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1021\/ol051962j","volume":"7","author":"Musialik M.","year":"2005","journal-title":"Org. Lett."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1016\/j.bmc.2007.06.001","volume":"15","author":"Pontiki E.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0166-2236(85)90010-4","volume":"8","author":"Halliwell B.","year":"1985","journal-title":"Trends Neurosci."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1016\/j.bmcl.2009.09.040","volume":"19","author":"Thalassitis A.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.freeradbiomed.2005.03.028","volume":"39","author":"Willmot M.","year":"2005","journal-title":"Free Radical Biol. Med."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"23679","DOI":"10.1074\/jbc.274.34.23679","volume":"274","author":"Brash A. R.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"18351","DOI":"10.1016\/S0021-9258(17)44759-4","volume":"265","author":"Kuhn H.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tcm.2004.04.003","volume":"14","author":"Zhao L.","year":"2004","journal-title":"Trends Cardiovasc. Med."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/jps.2600790219","volume":"79","author":"Taraborewala R. B.","year":"1990","journal-title":"J. Pharm. Sci."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/157340805774580466","volume":"1","author":"Pontiki E.","year":"2005","journal-title":"Curr. Enzyme Inhib."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1517\/13543771003602012","volume":"20","author":"Pergola C.","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/med.20099","volume":"28","author":"Pontiki E.","year":"2008","journal-title":"Med. Res. Rev."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1021\/jm00022a001","volume":"38","author":"Kerwin F.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref44\/cit44","volume-title":"Nitric Oxide: Biochemistry, Molecular Biology, And Therapeutic Implications","author":"Ignarro L.","year":"1995"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1389557013407160","volume":"1","author":"Bandarage U. K.","year":"2001","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4049\/jimmunol.165.3.1582","volume":"165","author":"Clancy R.","year":"2000","journal-title":"J. Immunol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1432-1033.1997.00608.x","volume":"245","author":"Holzhutter H. G.","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cber.187901201117","volume":"12","author":"Griess J. P.","year":"1879","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/jnnp.2006.100800","volume":"77","author":"Chamorro A.","year":"2006","journal-title":"Neurol., Neurosurg. Psychiatry"},{"key":"ref50\/cit50","unstructured":"Winter, C. A.InNon-steroidal Anti-inflammatory Drugs;Garattini, S.; Dukes, M. N. G., Eds.Excepta Medica:Amsterdam, 1965; p190."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/jm00084a019","volume":"53","author":"Kuroda T.","year":"1992","journal-title":"J. Med. Chem."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.0022-3042.2001.00697.x","volume":"80","author":"Adibhatla R. M.","year":"2002","journal-title":"J. Neurochem."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0223-5234(03)00012-6","volume":"38","author":"Di L.","year":"2003","journal-title":"Eur. J. Med. Chem."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1021\/jm050746d","volume":"49","author":"Rodr\u00edguez-Franco M. I.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"16458","DOI":"10.1021\/ja064657h","volume":"128","author":"Reviriego F.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuropharm.2006.03.029","volume":"51","author":"Pav\u00f3n F. J.","year":"2006","journal-title":"Neuropharmacology"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/cmdc.200800414","volume":"4","author":"Fern\u00e1ndez-Bachiller M. I.","year":"2009","journal-title":"ChemMedChem"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1021\/jm801292b","volume":"52","author":"Marco-Contelles J.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1021\/jm900628z","volume":"52","author":"Arce M. P.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1021\/jm900859q","volume":"52","author":"Camps P.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1021\/jm100329q","volume":"53","author":"Fern\u00e1ndez-Bachiller M. I.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.1016\/j.ejmech.2010.09.039","volume":"45","author":"Gonz\u00e1lez-Mu\u00f1oz G. C.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/cmdc.201000322","volume":"5","author":"Viayna E.","year":"2010","journal-title":"ChemMedChem"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.ejmech.2011.03.003","volume":"46","author":"Gonz\u00e1lez-Mu\u00f1oz G. C.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.nbd.2004.10.006","volume":"18","author":"Hurtado O.","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1471-4159.1998.71062549.x","volume":"71","author":"Hensley K.","year":"1998","journal-title":"J. Neurochem."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.bcp.2007.12.010","volume":"75","author":"Soto-Otero R.","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10715760100301471","volume":"35","author":"Coffey M. J.","year":"2001","journal-title":"Free Radical Res."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1016\/j.bmc.2010.10.012","volume":"18","author":"Hadjipavlou-Litina D.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1016\/j.ejmech.2010.09.016","volume":"45","author":"Ispikoudi M.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0021-9258(18)66179-4","volume":"202","author":"Nason A.","year":"1953","journal-title":"J. Biol. Chem."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1104\/pp.28.2.233","volume":"28","author":"Evans H. J.","year":"1953","journal-title":"Plant Physiol."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1046\/j.1471-4159.1997.69041703.x","volume":"69","author":"Alc\u00e1zar A.","year":"1997","journal-title":"J. Neurochem."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"16579","DOI":"10.1074\/jbc.M212936200","volume":"278","author":"Quevedo C.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.76.1.514","volume":"76","author":"Bottenstein J. E.","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0165-5728(99)00225-8","volume":"104","author":"Alc\u00e1zar A.","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jnr.20739","volume":"83","author":"Figueroa S.","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4236\/nm.2010.12008","volume":"1","author":"Arce C.","year":"2010","journal-title":"Neurosci. Med."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm201105a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T03:20:22Z","timestamp":1713151222000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm201105a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,21]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1,12]]}},"alternative-id":["10.1021\/jm201105a"],"URL":"https:\/\/doi.org\/10.1021\/jm201105a","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,21]]}}}