{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:00:03Z","timestamp":1777640403061,"version":"3.51.4"},"reference-count":85,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2012,2,23]]},"DOI":"10.1021\/jm300031j","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T11:16:24Z","timestamp":1327576584000},"page":"1721-1730","source":"Crossref","is-referenced-by-count":223,"title":["Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo"],"prefix":"10.1021","volume":"55","author":[{"given":"Fabrizio","family":"Carta","sequence":"first","affiliation":[{"name":"Laboratorio di Chimica Bioinorganica, Polo\rScientifico, Universit\u00e0 degli Studi di Firenze, Room 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence,\rItaly"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayank","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\rand Molecular Biology, College of Medicine, University of Florida, Box 100245, Gainesville, Florida 32610,\rUnited States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Maresca","sequence":"additional","affiliation":[{"name":"Laboratorio di Chimica Bioinorganica, Polo\rScientifico, Universit\u00e0 degli Studi di Firenze, Room 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence,\rItaly"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[{"name":"Laboratorio di Chimica Bioinorganica, Polo\rScientifico, Universit\u00e0 degli Studi di Firenze, Room 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence,\rItaly"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\rand Molecular Biology, College of Medicine, University of Florida, Box 100245, Gainesville, Florida 32610,\rUnited States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Masini","sequence":"additional","affiliation":[{"name":"Department\rof Preclinical and Clinical Pharmacology, Universit\u00e0 degli Studi di Firenze, Viale Pierracini 6, Florence,\rItaly"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Laboratorio di Chimica Bioinorganica, Polo\rScientifico, Universit\u00e0 degli Studi di Firenze, Room 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence,\rItaly"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,2,13]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/cr050262p","volume":"108","author":"Krishnamurthy V. M.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.2174\/138161210793429832","volume":"16","author":"Zatovicova M.","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref1\/cit1c","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran C. T.","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref1\/cit1d","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4324\/9780203475300","volume-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","author":"Supuran C. T.","year":"2004"},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran C. T.","year":"2003","journal-title":"Med. Res. Rev."},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova P. S.","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref2\/cit2c","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry A.","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref3\/cit3a","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran C. T.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref3\/cit3b","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.4155\/fmc.11.69","volume":"3","author":"Supuran C. T.","year":"2011","journal-title":"Future Med. Chem."},{"key":"ref3\/cit3c","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.2174\/138161210793429814","volume":"16","author":"Nishimori I.","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphar.2011.00034","volume":"2","author":"Supuran C. T.","year":"2011","journal-title":"Front. Pharmacol."},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.2174\/138161210793429850","volume":"16","author":"Winum J. Y.","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1021\/jm901888x","volume":"53","author":"Lopez M.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"\u0160vastov\u00e1 E.","year":"2004","journal-title":"FEBS Lett."},{"issue":"1","key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756360902784425","volume":"24","author":"Ebbesen P.","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.radonc.2009.06.019","volume":"92","author":"Dubois L.","year":"2009","journal-title":"Radiother. Oncol."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.bmcl.2009.06.022","volume":"19","author":"Ahlskog J. K. J.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref6\/cit6c","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1021\/cb1003477","volume":"6","author":"Buller F.","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"ref6\/cit6d","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-08-2470","volume":"69","author":"Chiche J.","year":"2009","journal-title":"Cancer Res."},{"key":"ref6\/cit6e","doi-asserted-by":"crossref","first-page":"20473","DOI":"10.1074\/jbc.M801330200","volume":"283","author":"Swietach P.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138161208783877947","volume":"14","author":"Supuran C. T.","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref7\/cit7b","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone G.","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref7\/cit7c","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1021\/jm031116j","volume":"4","author":"de Leval X.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0163-7258(89)90049-1","volume":"43","author":"Sugrue M. F.","year":"1999","journal-title":"Pharmacol. Ther."},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1517\/13543776.2012.649006","volume":"22","author":"Carta F.","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2174\/138161208783877866","volume":"14","author":"Mincione F.","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/9780470508169.ch5","volume-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","author":"Mincione F.","year":"2009"},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1016\/j.bmcl.2009.10.036","volume":"19","author":"Steele R. M.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1016\/j.bmcl.2011.04.046","volume":"21","author":"Mincione F.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref10\/cit10c","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/14756366.2011.597749","volume":"27","author":"Fabrizi F.","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1517\/13543776.10.5.575","volume":"10","author":"Supuran C. T.","year":"2000","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/jmg.40.4.257","volume":"40","author":"Liao S. Y.","year":"2003","journal-title":"J. Med. Genet."},{"key":"ref13\/cit13a","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s004180000181","volume":"114","author":"Kivel\u00e4 A. J.","year":"2000","journal-title":"Histochem. Cell Biol."},{"key":"ref13\/cit13b","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/sj.bjc.6603530","volume":"96","author":"Hussain S. A.","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref13\/cit13c","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00428-010-0938-0","volume":"457","author":"Chen C. L.","year":"2010","journal-title":"Virchows Arch."},{"key":"ref14\/cit14a","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1200\/JCO.2001.19.16.3660","volume":"19","author":"Chia S. K.","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"ref14\/cit14b","first-page":"7075","volume":"60","author":"Wykoff C. C.","year":"2000","journal-title":"Cancer Res."},{"key":"ref14\/cit14c","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1120","volume":"197","author":"Bartosova M.","year":"2002","journal-title":"J. Pathol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri D.","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1158\/0008-5472.CAN-11-2520","volume":"71","author":"Ditte P.","year":"2011","journal-title":"Cancer Res."},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.eururo.2010.03.015","volume":"58","author":"Stillebroer A. B.","year":"2010","journal-title":"Eur. Urol."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00345-010-0570-2","volume":"29","author":"Siebels M.","year":"2011","journal-title":"World J. Urol."},{"key":"ref17\/cit17c","first-page":"495","volume":"46","author":"van Schaijk F. G.","year":"2005","journal-title":"J. Nucl. Med."},{"key":"ref18\/cit18a","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-10-4261","volume":"71","author":"Lou Y.","year":"2011","journal-title":"Cancer Res."},{"key":"ref18\/cit18b","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1021\/jm101541x","volume":"54","author":"Pacchiano F.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19a","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.bmcl.2011.10.058","volume":"22","author":"Groves K.","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1021\/jm200983e","volume":"54","author":"Touisni N.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref20\/cit20a","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca A.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref20\/cit20b","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","volume":"53","author":"Maresca A.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1021\/jm1003667","volume":"53","author":"Carta F.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22a","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.bmcl.2008.01.077","volume":"18","author":"Innocenti A.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref22\/cit22b","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.1016\/j.bmc.2008.06.013","volume":"16","author":"Innocenti A.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref23\/cit23a","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.bmcl.2009.02.088","volume":"19","author":"Innocenti A.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref23\/cit23b","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.bmcl.2010.01.081","volume":"20","author":"Innocenti A.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bmcl.2009.11.124","volume":"20","author":"Temperini C.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1039\/c2cc16395k","volume":"48","author":"Carta F.","year":"2012","journal-title":"Chem. Commun. (Cambridge)"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ijc.25684","volume":"129","author":"Marzano C.","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3109\/14756360903179351","volume":"25","author":"Amin E.","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0167-4838(83)90071-7","volume":"746","author":"Morpurgo L.","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3109\/14756366.2011.554415","volume":"26","author":"Kolayli S.","year":"2011","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref30\/cit30a","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/j.ejmech.2007.10.024","volume":"43","author":"Kiran Kumar S. T. V. S.","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"ref30\/cit30b","unstructured":"bMaatschappij, B. V.Organic molibdenum compounds, use thereof as friction modifiers and lubricating compositions, W.O. Patent 113814 A1, 2008."},{"key":"ref30\/cit30c","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s11173-005-0157-4","volume":"31","author":"Ivanov A. V.","year":"2005","journal-title":"Russ. J. Coord. Chem."},{"key":"ref30\/cit30d","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ica.2011.01.006","volume":"368","author":"Rodina T. A.","year":"2011","journal-title":"Inorg. Chim. Acta"},{"key":"ref30\/cit30e","unstructured":"eTreasurywala, A. A. M.; Bagli, J.; Baker, H.Substituted pyrimidones with antifungal properties. CA Pat. 1232904, 1996."},{"key":"ref30\/cit30f","first-page":"175","volume":"31","author":"Soliman R.","year":"1990","journal-title":"Egypt. J. Chem."},{"key":"ref31\/cit31","first-page":"44","volume":"401","author":"Ivanov A. V.","year":"2005","journal-title":"Phys. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah R. G.","year":"1971","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33a","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/jm990479+","volume":"43","author":"Scozzafava A.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref33\/cit33b","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/14756360009040695","volume":"15","author":"Supuran C. T.","year":"2000","journal-title":"J. Enzyme Inhib."},{"key":"ref34\/cit34a","first-page":"73","volume-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","author":"Alterio V.","year":"2009"},{"key":"ref34\/cit34b","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio V.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref35\/cit35a","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","volume":"13","author":"Casini A.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref35\/cit35b","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bmcl.2005.03.032","volume":"15","author":"De Simone G.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref35\/cit35c","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/jm901524f","volume":"53","author":"Temperini C.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref36\/cit36a","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1016\/j.bmcl.2010.06.082","volume":"20","author":"Avvaru B. S.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref36\/cit36b","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1016\/j.bmc.2010.06.028","volume":"18","author":"Wagner J. M.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref36\/cit36c","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1039\/c0cc02707c","volume":"46","author":"Pacchiano F.","year":"2010","journal-title":"Chem. Commun. (Cambridge)"},{"key":"ref37\/cit37","volume-title":"Preparation and Analysis of Protein Crystals","author":"McPherson A.","year":"1982","edition":"1"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/bi902007b","volume":"49","author":"Avvaru B. S.","year":"2010","journal-title":"Biochemistry"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S010876731009968X","volume":"66","author":"Adams P. D.","year":"2010","journal-title":"Acta Crystallogr."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/355472a0","volume":"355","author":"Brunger A. T.","year":"1992","journal-title":"Nature"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley P.","year":"2004","journal-title":"Acta Crystallogr., Sect. D"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm300031j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:35:08Z","timestamp":1680654908000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm300031j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,13]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,2,23]]}},"alternative-id":["10.1021\/jm300031j"],"URL":"https:\/\/doi.org\/10.1021\/jm300031j","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,13]]}}}