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Anaesth."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1124\/mol.106.030049","volume":"71","author":"Zeller A.","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12630-010-9429-7","volume":"58","author":"Olsen R. W.","year":"2011","journal-title":"Can. J. Anaesth."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1124\/jpet.110.170472","volume":"335","author":"McCracken M. L.","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1021\/jm051207b","volume":"49","author":"Husain S. S.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.1021\/jm100498u","volume":"53","author":"Husain S. S.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1021\/cn900014m","volume":"1","author":"Eckenhoff R. G.","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1021\/jm1004072","volume":"53","author":"Hall M. A.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"8124","DOI":"10.1021\/jm200943f","volume":"54","author":"Stewart D. S.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"11599","DOI":"10.1523\/JNEUROSCI.3467-06.2006","volume":"26","author":"Li G. D.","year":"2006","journal-title":"J. Neurosci."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/bi201772m","volume":"51","author":"Chiara D. 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R. Soc. Seances Soc. Biol. Fil."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1749-6632.1970.tb53439.x","volume":"173","author":"DeLong D. C.","year":"1970","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.1016\/j.bmc.2006.07.047","volume":"14","author":"Chen Q. -H.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/S0040-4020(01)82572-2","volume":"23","author":"Morgan E. D.","year":"1967","journal-title":"Tetrahedron"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1021\/jo00231a036","volume":"52","author":"Creary X.","year":"1987","journal-title":"J. Org. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1021\/ol063074+","volume":"9","author":"Volonterio A.","year":"2007","journal-title":"Org. Lett."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/jo981065b","volume":"64","author":"Oh C. H.","year":"1999","journal-title":"J. Org. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1021\/jo00088a035","volume":"59","author":"Ansong O.","year":"1994","journal-title":"J. Org. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1021\/bi00528a019","volume":"20","author":"Brunner J.","year":"1981","journal-title":"Biochemistry"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1021\/jo902733f","volume":"75","author":"Zagulyaeva A. A.","year":"2010","journal-title":"J. Org. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1039\/a704062h","author":"Shah A.","year":"1997","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1021\/jo8004974","volume":"73","author":"Bielawski M.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/chir.20398","volume":"19","author":"Ghanem A.","year":"2007","journal-title":"Chirality"},{"key":"ref40\/cit40","first-page":"549","volume":"269","author":"Bideau J. P.","year":"1969","journal-title":"C. R. Seances Acad. Sci. C"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1002\/1099-0690(200110)2001:20<3961::AID-EJOC3961>3.0.CO;2-R","author":"Ambroise Y.","year":"2001","journal-title":"Eur. J. Org. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1248\/cpb.55.1540","volume":"55","author":"Hashimoto M.","year":"2007","journal-title":"Chem. Pharm. 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Pharmacol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/chir.1054","volume":"13","author":"Brunner H.","year":"2001","journal-title":"Chirality"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.bjp.0702744","volume":"128","author":"Cordato D. J.","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1097\/00000542-199906000-00029","volume":"90","author":"Tomlin S. L.","year":"1999","journal-title":"Anesthesiology"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1097\/00000542-199906000-00028","volume":"90","author":"Kamiya Y.","year":"1999","journal-title":"Anesthesiology"},{"key":"ref52\/cit52","first-page":"709","volume":"175","author":"B\u00fcch H.","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ardp.19963290805","volume":"329","author":"B\u00fcch H. P.","year":"1996","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0301-0082(82)90013-2","volume":"18","author":"Richter J. A.","year":"1982","journal-title":"Prog. Neurobiol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jlac.19717500104","volume":"750","author":"Knabe J.","year":"1971","journal-title":"Liebigs Ann. Chem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0041-008X(73)90287-1","volume":"26","author":"Christensen H. D.","year":"1973","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-2007-1000263","volume":"27","author":"Tonner P. H.","year":"1992","journal-title":"Anasthesiol. Intensivmed. Notfallmed. Schmerzther."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1096\/fj.02-0611fje","volume":"17","author":"Jurd. R.","year":"2003","journal-title":"FASEB J."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/00000542-199311000-00022","volume":"79","author":"de Armendi A. J.","year":"1993","journal-title":"Anesthesiology"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature09647","volume":"469","author":"Nury H. C.","year":"2011","journal-title":"Nature"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","volume":"66","author":"Kabsch W.","year":"2010","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"64","author":"Sheldrick G. 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