{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:05:49Z","timestamp":1777421149265,"version":"3.51.4"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2012,8,9]]},"DOI":"10.1021\/jm300689c","type":"journal-article","created":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T13:39:14Z","timestamp":1341927554000},"page":"6898-6915","source":"Crossref","is-referenced-by-count":35,"title":["Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases"],"prefix":"10.1021","volume":"55","author":[{"given":"Stefania","family":"Butini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Brindisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Gemma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Minetti","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Cabri","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Gallo","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Vincenti","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Talamonti","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale\re Chirurgia, Universit\u00e0 degli Studi di Roma \u201cTor Vergata\u201d,\r00133 Rome, Italy"},{"name":"Centro\rEuropeo di Ricerca sul\rCervello (CERC)\/IRCCS Fondazione Santa Lucia, 00143 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Borsini","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Stasi","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Di Serio","sequence":"additional","affiliation":[{"name":"Sigma-Tau Industrie Farmaceutiche\rRiunite spa, Via Pontina Km 30400, 00040 Pomezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindu","family":"Ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuele","family":"Maramai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Fezza","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale\re Chirurgia, Universit\u00e0 degli Studi di Roma \u201cTor Vergata\u201d,\r00133 Rome, Italy"},{"name":"Centro\rEuropeo di Ricerca sul\rCervello (CERC)\/IRCCS Fondazione Santa Lucia, 00143 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Campiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Maccarrone","sequence":"additional","affiliation":[{"name":"Centro\rEuropeo di Ricerca sul\rCervello (CERC)\/IRCCS Fondazione Santa Lucia, 00143 Rome, Italy"},{"name":"Dipartimento di Scienze Biomediche,\rUniversit\u00e0 degli Studi di Teramo, Piazza Aldo Moro 45, 64100\rTeramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,7,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","volume":"258","author":"Devane W. A.","year":"1992","journal-title":"Science"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","volume":"50","author":"Mechoulam R.","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"17541","DOI":"10.1073\/pnas.0508644102","volume":"102","author":"Mechoulam R.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"17852","DOI":"10.1073\/pnas.0507470102","volume":"102","author":"Moore S. A.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1073\/pnas.0901515106","volume":"106","author":"Kaczocha M.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tibs.2010.05.008","volume":"35","author":"Maccarrone M.","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/384083a0","volume":"384","author":"Cravatt B. F.","year":"1996","journal-title":"Nature"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"20270","DOI":"10.1073\/pnas.0909411106","volume":"106","author":"Long J. Z.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1074\/jbc.M413473200","volume":"280","author":"Tsuboi K.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"27218","DOI":"10.1074\/jbc.272.43.27218","volume":"272","author":"Karlsson M.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1021\/jm800311k","volume":"51","author":"Seierstad M.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1073\/pnas.94.6.2238","volume":"94","author":"Giang D. K.","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.pain.2004.01.022","volume":"109","author":"Lichtman A. H.","year":"2004","journal-title":"Pain"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI200419465","volume":"113","author":"Massa F.","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/sleep\/27.5.857","volume":"27","author":"Huitron-Resendiz S.","year":"2004","journal-title":"Sleep"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/sj.npp.1301224","volume":"32","author":"Varvel S. A.","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1126\/science.1076535","volume":"298","author":"Bracey M. H.","year":"2002","journal-title":"Science"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0006-2952(96)00830-1","volume":"53","author":"Deutsch D. G.","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1021\/jm021119g","volume":"46","author":"Tarzia G.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1021\/jm031140x","volume":"47","author":"Mor M.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/jms.729","volume":"39","author":"Basso E.","year":"2004","journal-title":"J. Mass Spectrom."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.chembiol.2005.08.011","volume":"12","author":"Alexander J. P.","year":"2005","journal-title":"Chem. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1073\/pnas.97.10.5044","volume":"97","author":"Boger D. L.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0960-894X(01)00211-6","volume":"11","author":"Boger D. L.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1021\/jm101597x","volume":"54","author":"Ezzili C.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1021\/jm049614v","volume":"48","author":"Boger D. L.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1124\/jpet.104.069401","volume":"311","author":"Lichtman A. H.","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref28\/cit28","unstructured":"Cabri, W.; Minetti, P.; Campiani, G.; Butini, S.:New carbamate derivatives as modulators of fatty acid amide hydrolase (FAAH inhibitors). Patent EP09155528, 2009."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0040-4039(00)02195-X","volume":"42","author":"Talukdar S.","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00421-004-1241-z","volume":"93","author":"Minetto M.","year":"2005","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF00401402","volume":"13","author":"Irwin S.","year":"1968","journal-title":"Psychopharmacologia"},{"key":"ref32\/cit32","first-page":"409","volume":"111","author":"Randall L. O.","year":"1957","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"ref33\/cit33","unstructured":"Prime Protein Structure Prediction Suite,version 2.0;Schr\u00f6dinger LLC:1500 S.W. First Avenue, Suite 1180 Portland, OR 97201-5815."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/prot.340120407","volume":"12","author":"Morris A. L.","year":"1992","journal-title":"Proteins"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1039\/B714136J","author":"Lodola A.","year":"2008","journal-title":"Chem. Commun."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/cmdc.200900472","volume":"5","author":"Gattinoni S.","year":"2010","journal-title":"ChemMedChem"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm300689c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T10:25:04Z","timestamp":1680431104000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm300689c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,26]]},"references-count":37,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2012,8,9]]}},"alternative-id":["10.1021\/jm300689c"],"URL":"https:\/\/doi.org\/10.1021\/jm300689c","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,26]]}}}