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Med."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0378-1119(85)90272-0","volume":"37","author":"Sasaki H.","year":"1985","journal-title":"Gene"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/01.LAB.0000059937.11023.1F","volume":"83","author":"Sekijima Y.","year":"2003","journal-title":"Lab. Invest."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1021\/bi027319b","volume":"42","author":"Hammarstrom P.","year":"2003","journal-title":"Biochemistry"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00019052-200010000-00011","volume":"13","author":"Plante-Bordeneuve V.","year":"2000","journal-title":"Curr. Opin. 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Chem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.molonc.2008.02.004","volume":"2","author":"Zache N.","year":"2008","journal-title":"Mol. Oncol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1073\/pnas.0607286103","volume":"103","author":"Joerger A. C.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"10360","DOI":"10.1073\/pnas.0805326105","volume":"105","author":"Boeckler F. M.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.chembiol.2009.12.011","volume":"17","author":"Basse N.","year":"2010","journal-title":"Chem. Biol."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"10198","DOI":"10.1074\/jbc.M109.083469","volume":"285","author":"Demma M.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.biophys.29.1.105","volume":"29","author":"Goodsell D. S.","year":"2000","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0003-9861(85)90380-7","volume":"241","author":"Lepock J. R.","year":"1985","journal-title":"Arch. Biochem. Biophys."},{"key":"ref63\/cit63","volume-title":"Maestro","year":"2012","edition":"9"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"Gurney M. E.","year":"1994","journal-title":"Science"},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2990.1996.tb00907.x","volume":"22","author":"Bruijn L. I.","year":"1996","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref66\/cit66","first-page":"1508","volume":"6","author":"Wang Q.","year":"2008","journal-title":"PLoS Biol."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bbadis.2006.05.004","volume":"1762","author":"Rakhit R.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"15923","DOI":"10.1074\/jbc.M112087200","volume":"277","author":"Hayward L. J.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1074\/jbc.M210419200","volume":"278","author":"Tiwari A.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1073\/pnas.0305143101","volume":"101","author":"Hough M. A.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. 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Chem."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/17482968.2010.522586","volume":"2","author":"Benmohamed R.","year":"2011","journal-title":"Amyotrophic Lateral Scler."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/jm2014277","volume":"55","author":"Chen T.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.bmc.2011.11.039","volume":"20","author":"Zhang W.","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"21394","DOI":"10.1073\/pnas.1015463107","volume":"107","author":"Auclair J. R.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1098\/rspb.1922.0023","volume":"93","author":"Fleming A.","year":"1922","journal-title":"Proc. R. Soc. London, Ser. B"},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/206757a0","volume":"206","author":"Blake C. C. F.","year":"1965","journal-title":"Nature"},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/scientificamerican1166-78","volume":"215","author":"Phillips D. C.","year":"1966","journal-title":"Sci. Am."},{"key":"ref82\/cit82","first-page":"211","volume":"8","author":"Reitamo S.","year":"1978","journal-title":"Ricerca Clin. Lab."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00285225","volume":"63","author":"Jolles P.","year":"1984","journal-title":"Mol. Cell. Biochem."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/362553a0","volume":"362","author":"Pepys M. 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D.","year":"1994","journal-title":"Biochemistry"},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1432-1327.2001.01863.x","volume":"268","author":"Takano K.","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jmb.2005.06.035","volume":"351","author":"Wain R.","year":"2005","journal-title":"J. Mol. Biol."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","unstructured":"Dumoulin, M.InFamilial Amyloidosis Caused by Lysozyme in Protein Misfolding Diseases: Current and Emerging Principles and Therapies;Ramirez-Alvarado, M.; Kelly, J. W.; Dobson, C. M., Eds.John Wiley & Sons, Inc.:Hoboken, NJ, 2010; pp867\u2013885.","DOI":"10.1002\/9780470572702.ch39"},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1021\/bp060264a","volume":"23","author":"Liu H.-L.","year":"2007","journal-title":"Biotechnol. Prog."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"25910","DOI":"10.1074\/jbc.M211000200","volume":"278","author":"Esposito G.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jmb.2005.07.040","volume":"352","author":"Johnson R. J.","year":"2005","journal-title":"J. Mol. Biol."},{"key":"ref96\/cit96","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/385787a0","volume":"385","author":"Booth D. R","year":"1997","journal-title":"Nature"},{"key":"ref97\/cit97","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nsb768","volume":"9","author":"Canet D.","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"ref98\/cit98","unstructured":"Dumoulin, M.; Johnson, J. R. K.; Bellotti, V.; Dobson, C. M.InProtein Misfolding, Aggregation, and Conformational Diseases;Sipe, J. 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M.","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref104\/cit104","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.mehy.2005.10.018","volume":"66","author":"Manley P. N.","year":"2006","journal-title":"Med. Hypotheses"},{"key":"ref105\/cit105","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1515\/CCLM.1999.063","volume":"37","author":"Yamada T.","year":"1999","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref106\/cit106","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1194\/jlr.M100388-JLR200","volume":"43","author":"Tam S. P.","year":"2002","journal-title":"J. Lipid Res."},{"key":"ref107\/cit107","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","volume":"340","author":"Gabay C.","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref108\/cit108","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3109\/s10165-006-0500-8","volume":"16","author":"Ajiro J.","year":"2006","journal-title":"Mod. Rheumatol."},{"key":"ref109\/cit109","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2796.2007.01838.x","volume":"262","author":"Maury C. P. J.","year":"2007","journal-title":"J. Intern. Med."},{"key":"ref110\/cit110","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/art.1780391016","volume":"39","author":"Hasegawa H.","year":"1996","journal-title":"Arthritis Rheum."},{"key":"ref111\/cit111","first-page":"850","volume":"29","author":"Nakamura T.","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref112\/cit112","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00005792-199107000-00002","volume":"70","author":"Gertz M. A.","year":"1991","journal-title":"Medicine"},{"key":"ref113\/cit113","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/art.24735","volume":"61","author":"Obici L.","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref114\/cit114","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.bbrc.2011.03.090","volume":"407","author":"Wang Y.","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref115\/cit115","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0140-6736(00)05252-1","volume":"358","author":"Gillmore J. D.","year":"2001","journal-title":"Lancet"},{"key":"ref116\/cit116","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMoa070265","volume":"356","author":"Lachmann H. J.","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref117\/cit117","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1517\/14656566.9.12.2117","volume":"9","author":"Pettersson T.","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1056\/NEJMoa065644","volume":"356","author":"Dember L. M.","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref119\/cit119","unstructured":"International Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Efficacy and Safety of KIACTA in Preventing Renal Function Decline in Patients With AA Amyloidosis (Clinical Trials.gov Identifier: NCT01215747).http:\/\/clinicaltrials.gov\/."},{"key":"ref120\/cit120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/128_2011_157","volume-title":"Prion Proteins","volume":"305","author":"Loyd S.","year":"2011"},{"key":"ref121\/cit121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/pri.4.2.11960","volume":"4","author":"Diaz-Espinoza R.","year":"2010","journal-title":"Prion"},{"key":"ref122\/cit122","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.semcdb.2011.04.002","volume":"5","author":"Moreno-Gonzalez I.","year":"2011","journal-title":"Semin.Cell Dev. Biol."},{"key":"ref123\/cit123","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.56.062404.172936","volume":"56","author":"Weissmann C.","year":"2005","journal-title":"Annu. Rev. Med."},{"key":"ref124\/cit124","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1002\/j.1460-2075.1996.tb01027.x","volume":"15","author":"Tatzelt J.","year":"1996","journal-title":"EMBO J."},{"key":"ref125\/cit125","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1074\/jbc.273.6.3484","volume":"273","author":"Caspi S.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref126\/cit126","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1073\/pnas.97.11.6073","volume":"97","author":"Perrier V.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref127\/cit127","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1073\/pnas.94.19.10069","volume":"94","author":"Kaneko K.","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref128\/cit128","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1021\/jm050610f","volume":"49","author":"Reddy T. R.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref129\/cit129","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejmech.2007.02.018","volume":"43","author":"Guo K","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"ref130\/cit130","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/cmdc.201000133","volume":"5","author":"Bolognesi M. L.","year":"2010","journal-title":"ChemMedChem"},{"key":"ref131\/cit131","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/0888-7543(92)90067-3","volume":"13","author":"van den Ouweland A. M.","year":"1992","journal-title":"Genomics"},{"key":"ref132\/cit132","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9343(98)00301-5","volume":"105","author":"Bichet D. G.","year":"1998","journal-title":"Am. J. Med."},{"key":"ref133\/cit133","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1681\/ASN.2005040371","volume":"16","author":"Fujiwara T. M.","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref134\/cit134","first-page":"F257","volume":"291","author":"Robben J. H.","year":"2006","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"ref135\/cit135","first-page":"1","volume":"19","author":"McKinley M. J.","year":"2004","journal-title":"News Physiol. Sci."},{"key":"ref136\/cit136","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0022-2836(05)80271-2","volume":"213","author":"Henderson R.","year":"1990","journal-title":"Mol. Biol."},{"key":"ref137\/cit137","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1023\/A:1007969526447","volume":"12","author":"Czaplewski C.","year":"1998","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref138\/cit138","doi-asserted-by":"crossref","first-page":"19","DOI":"10.18388\/abp.1998_4314","volume":"45","author":"Czaplewski C.","year":"1998","journal-title":"Acta Biochem. Pol."},{"key":"ref139\/cit139","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.semnephrol.2008.03.005","volume":"28","author":"Bichet D.","year":"2008","journal-title":"Semin. Nephrol."},{"key":"ref140\/cit140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1124\/pr.59.3.2","volume":"59","author":"Conn P.","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"ref141\/cit141","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1021\/bi002699r","volume":"40","author":"Morello J.","year":"2001","journal-title":"Biochemistry"},{"key":"ref142\/cit142","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/359233a0","volume":"359","author":"Rosenthal W. P.","year":"1992","journal-title":"Nature"},{"key":"ref143\/cit143","first-page":"1985","volume-title":"The Metabolic Basis of Inherited Disease","author":"Reeves W.","year":"1989"},{"key":"ref144\/cit144","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/jcp.21552","volume":"217","author":"Spanakis E.","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"ref145\/cit145","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1172\/JCI8688","volume":"105","author":"Morello J.","year":"2000","journal-title":"J. Clin. Invest."},{"key":"ref146\/cit146","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.coph.2004.08.001","volume":"4","author":"Bernier V.","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref147\/cit147","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1210\/me.2004-0080","volume":"18","author":"Bernier V.","year":"2004","journal-title":"Mol. Endocirnol."},{"key":"ref148\/cit148","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1681\/ASN.2005080854","volume":"17","author":"Bernier V.","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref149\/cit149","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1440-1797.2006.00759.x","volume":"12","author":"Cheong H.","year":"2007","journal-title":"Nephrology"},{"key":"ref150\/cit150","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1091\/mbc.e05-06-0579","volume":"17","author":"Robben J.","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"ref151\/cit151","doi-asserted-by":"crossref","first-page":"47254","DOI":"10.1074\/jbc.M408154200","volume":"279","author":"Wuller S.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref152\/cit152","doi-asserted-by":"crossref","first-page":"20676","DOI":"10.1074\/jbc.M611530200","volume":"282","author":"Oueslati M.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref153\/cit153","volume-title":"GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Direction","author":"Valenzano K. J.","year":"2010"},{"key":"ref154\/cit154","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/00063030-200721030-00003","volume":"21","author":"Robben J.","year":"2007","journal-title":"BioDrugs"},{"key":"ref155\/cit155","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1517\/14728214.2010.512287","volume":"15","author":"Stockley R. A.","year":"2010","journal-title":"Expert Opin. Emerging Drugs"},{"key":"ref156\/cit156","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI0216787","volume":"110","author":"Perlmutter D. H.","year":"2002","journal-title":"J. Clin. Invest."},{"key":"ref157\/cit157","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1513\/pats.201002-019AW","volume":"7","author":"Greene C. M.","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"ref158\/cit158","doi-asserted-by":"crossref","first-page":"9548","DOI":"10.1074\/jbc.274.14.9548","volume":"274","author":"Dafforn T. R.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref159\/cit159","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1021\/bi048662e","volume":"44","author":"Purkayastha P.","year":"2005","journal-title":"Biochemistry"},{"key":"ref160\/cit160","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/35038119","volume":"407","author":"Huntington J. A.","year":"2000","journal-title":"Nature"},{"key":"ref161\/cit161","volume-title":"Molecular Operating Environment (MOE)","year":"2011","edition":"2011"},{"key":"ref162\/cit162","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/S0140-6736(05)66781-5","volume":"365","author":"Stoller J. K.","year":"2005","journal-title":"Lancet"},{"key":"ref163\/cit163","unstructured":"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00670007?term=alpha-1-antitrypsin&phase=3&rank=2."},{"key":"ref164\/cit164","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0014-5793(84)81279-X","volume":"177","author":"Bathurst I. C.","year":"1984","journal-title":"FEBS Lett."},{"key":"ref165\/cit165","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1172\/JCI113214","volume":"80","author":"Ogushi F.","year":"1987","journal-title":"J. Clin. Invest."},{"key":"ref166\/cit166","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1073\/pnas.97.4.1796","volume":"97","author":"Burrows J. A.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref167\/cit167","first-page":"2540","volume":"273","author":"Sharpe L. K.","year":"2006","journal-title":"FEBS J."},{"key":"ref168\/cit168","doi-asserted-by":"crossref","first-page":"15116","DOI":"10.1074\/jbc.M211663200","volume":"278","author":"Zhou A.","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"39","key":"ref169\/cit169","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00005176-200407000-00007","volume":"1","author":"Teckman J. H.","year":"2004","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref170\/cit170","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1021\/jm070687z","volume":"50","author":"Mallya M.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref171\/cit171","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1110\/ps.840101","volume":"10","author":"Lee C.","year":"2001","journal-title":"Protein Sci."},{"key":"ref172\/cit172","doi-asserted-by":"crossref","first-page":"33060","DOI":"10.1074\/jbc.M302646200","volume":"278","author":"Parfrey H","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref173\/cit173","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1111\/j.1582-4934.2008.00608.x","volume":"13","author":"Chang Y.-P.","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref174\/cit174","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1432-1033.1990.tb19425.x","volume":"194","author":"Schulze A. J.","year":"1990","journal-title":"Eur. J. 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