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Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1021\/ja01469a012","volume":"83","author":"Drago R. S.","year":"1961","journal-title":"J. Am. Chem. Soc."},{"key":"ref17\/cit17","first-page":"409","volume":"2","author":"Shami P. J.","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/jm00115a013","volume":"34","author":"Maragos C. M.","year":"1991","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.bmc.2012.01.046","volume":"20","author":"Nandurdikar R. S.","year":"2012","journal-title":"Bioorg. Med. 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