{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:56:56Z","timestamp":1792623416032,"version":"4.5.0"},"reference-count":111,"publisher":"American Chemical Society (ACS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2013,7,25]]},"DOI":"10.1021\/jm301424d","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T12:09:42Z","timestamp":1366718982000},"page":"5637-5658","source":"Crossref","is-referenced-by-count":88,"title":["Inhibition of Rhodesain as a Novel Therapeutic Modality for Human African Trypanosomiasis"],"prefix":"10.1021","volume":"56","author":[{"given":"Roberta","family":"Ettari","sequence":"first","affiliation":[{"name":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli\r25, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Tamborini","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli\r25, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia C.","family":"Angelo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del\rFarmaco e Prodotti per la Salute, Universit\u00e0 degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Micale","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del\rFarmaco e Prodotti per la Salute, Universit\u00e0 degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pinto","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli\r25, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"De Micheli","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli\r25, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Conti","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli\r25, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.idc.2004.01.004","volume":"18","author":"Cox F. E. G.","year":"2004","journal-title":"Infect. Dis. Clin. North Am."},{"key":"ref2\/cit2","unstructured":"Trypanosomiasis, Human African (Sleeping Sickness).http:\/\/www.who.int\/mediacentre\/factsheets\/fs259\/en\/."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(03)14694-6","volume":"362","author":"Barrett M. P.","year":"2003","journal-title":"Lancet"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1172\/JCI200421052","volume":"113","author":"Kennedy P. G. E.","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1242\/jcs.112.19.3187","volume":"112","author":"Turner C. M.","year":"1999","journal-title":"J. Cell Sci."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(01)49037-3","volume":"49","author":"Barry J. D.","year":"2001","journal-title":"Adv. Parasitol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(08)60410-8","volume":"33","author":"P\u00e9pin J.","year":"1994","journal-title":"Adv. Parasitol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.drup.2007.02.004","volume":"10","author":"Delespaux V.","year":"2007","journal-title":"Drug Resist. Updates"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.bjp.0707354","volume":"152","author":"Barrett M. P.","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1007\/s00436-002-0766-5","volume":"90","author":"Burri C.","year":"2003","journal-title":"Parasitol. Res."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0074-02762002000100001","volume":"97","author":"Coura J. R.","year":"2002","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref12\/cit12a","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0140-6736(09)61117-X","volume":"374","author":"Priotto G.","year":"2009","journal-title":"Lancet"},{"key":"ref12\/cit12b","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1086\/510534","volume":"195","author":"Bisser S.","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1128\/AAC.00831-08","volume":"53","author":"Mdachi R. E.","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1586\/14787210.5.6.921","volume":"5","author":"Chen D.","year":"2007","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"e1151","DOI":"10.1371\/journal.pntd.0001151","volume":"5","author":"Jacobs R. T.","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev.mi.46.100192.003403","volume":"46","author":"Fairlamb A. H.","year":"1992","journal-title":"Annu. Rev. Microbiol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1054\/drup.2000.0177","volume":"4","author":"Verlinde C. L.","year":"2001","journal-title":"Drug Resist. Updates"},{"key":"ref18\/cit18a","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cmdc.201000417","volume":"6","author":"Conti P.","year":"2011","journal-title":"ChemMedChem"},{"key":"ref18\/cit18b","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/cmdc.201200304","volume":"7","author":"Tamborini L.","year":"2012","journal-title":"ChemMedChem"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/infdis\/jir857","volume":"206","author":"de Koning H. P.","year":"2012","journal-title":"J. Infect. Dis."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nature08893","volume":"464","author":"Frearson J. A.","year":"2010","journal-title":"Nature"},{"key":"ref21\/cit21a","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0968-0896(99)00008-5","volume":"7","author":"McKerrow J. H.","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"ref21\/cit21b","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1389450003349290","volume":"1","author":"Caffrey C. R.","year":"2000","journal-title":"Curr. Drug Targets"},{"key":"ref21\/cit21c","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.biochem.71.090501.145453","volume":"71","author":"Klemba M.","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"ref22\/cit22a","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/expr.1998.4381","volume":"91","author":"Scory S.","year":"1999","journal-title":"Exp. Parasitol."},{"key":"ref22\/cit22b","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/expr.1998.4386","volume":"91","author":"Troeberg L.","year":"1999","journal-title":"Exp. Parasitol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"48426","DOI":"10.1074\/jbc.M402470200","volume":"279","author":"Mackey Z. B.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1371\/journal.pntd.0000298","volume":"2","author":"Abdulla M. H.","year":"2008","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ijpara.2012.03.009","volume":"42","author":"Steverding D.","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"25697","DOI":"10.1074\/jbc.M109.014340","volume":"284","author":"Kerr I. D.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"e701","DOI":"10.1371\/journal.pntd.0000701","volume":"4","author":"Kerr I. D.","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrd2092","volume":"5","author":"Turk B.","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1471-4922(01)02120-1","volume":"18","author":"Lonsdale-Eccles J. D.","year":"2002","journal-title":"Trends Parasitol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1172\/JCI27798.","volume":"116","author":"Nikolskaia O. V.","year":"2006","journal-title":"J. Clin. Invest."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"No e479","DOI":"10.1371\/journal.pntd.0000479","volume":"3","author":"Grab D. J.","year":"2009","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0169-4758(94)90393-X","volume":"10","author":"Overath P.","year":"1994","journal-title":"Parasitol. Today"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1128\/EC.2.1.76-83.2003","volume":"2","author":"Triggs V. P.","year":"2003","journal-title":"Eukaryotic Cell"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0166-6851(01)00368-1","volume":"118","author":"Caffrey C. R.","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1515\/BC.2002.077","volume":"383","author":"Lalmanach G.","year":"2002","journal-title":"Biol. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2174\/156802610790725498","volume":"10","author":"Ludewig S.","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0924-8579(03)00096-7","volume":"22","author":"Nkemngu N. J.","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1055\/s-2001-17351","volume":"67","author":"Merchjohann K.","year":"2001","journal-title":"Planta Med."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0924-8579(01)00488-5","volume":"19","author":"Caffrey C. R.","year":"2002","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1021\/jm00017a002","volume":"38","author":"Palmer J. T.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"12824","DOI":"10.1074\/jbc.M513331200","volume":"281","author":"Choe Y.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"28934","DOI":"10.1074\/jbc.M805824200","volume":"283","author":"O\u2019Brien T. C.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.bmcl.2007.11.070","volume":"18","author":"Jaishankar P.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref44\/cit44a","first-page":"360","volume":"26","author":"Zhang Y.","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"ref44\/cit44b","first-page":"1343","volume":"28","author":"Jacobsen W.","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1021\/jm0504961","volume":"48","author":"Falgueyret J. P.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/nature09224","volume":"465","author":"Clayton J.","year":"2010","journal-title":"Nature"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1021\/jm900629w","volume":"52","author":"Machon U.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/jm900946n","volume":"53","author":"Breuning A.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.1016\/S0021-9258(18)98753-3","volume":"266","author":"Yamamoto D.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref50\/cit50a","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/S0968-0896(98)80022-9","volume":"6","author":"Scheidt K.","year":"1998","journal-title":"Bioorg. Med. Chem."},{"key":"ref50\/cit50b","doi-asserted-by":"crossref","first-page":"10994","DOI":"10.1021\/ja981792o","volume":"120","author":"Roush W. R.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref50\/cit50c","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/S0960-894X(01)00566-2","volume":"11","author":"Roush W. R.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1016\/j.bmcl.2007.10.056","volume":"17","author":"Gonzalez F. V.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.bmcl.2006.02.026","volume":"16","author":"Vicik R.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cmdc.201000370","volume":"6","author":"B\u00fcchold C.","year":"2011","journal-title":"ChemMedChem"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1002\/chem.201103322","volume":"18","author":"Yang P.-Y.","year":"2012","journal-title":"Chem.\u2014Eur. J."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1002\/anie.200705858","volume":"47","author":"L\u00f6ser R.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2174\/1389557023405828","volume":"2","author":"Ahn J.-M.","year":"2002","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1016\/S0040-4020(01)00680-9","volume":"57","author":"Souers A. J.","year":"2001","journal-title":"Tetrahedron"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1021\/ar9901523","volume":"34","author":"Burgess K.","year":"2001","journal-title":"Acc. Chem. Res."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2174\/1385272013375517","volume":"5","author":"MacDonald M.","year":"2001","journal-title":"Curr. Org. Chem"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/1389557023405783","volume":"2","author":"Eguchi M.","year":"2002","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0960-894X(99)00015-3","volume":"9","author":"Dziadulewicz E. K.","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0960-894X(02)00107-5","volume":"12","author":"Lauffer D. J.","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1021\/jm060405f","volume":"49","author":"Micale N.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/j.ejmech.2010.04.003","volume":"7","author":"Ettari R.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10822-012-9596-4","volume":"26","author":"Grazioso G.","year":"2012","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1016\/j.bmc.2010.06.010","volume":"18","author":"Bova F.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/cmdc.201200274","volume":"7","author":"Ettari R.","year":"2012","journal-title":"ChemMedChem"},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0969-2126(00)00173-8","volume":"8","author":"Brinen L. S.","year":"2000","journal-title":"Structure"},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1016\/j.bmcl.2008.06.012","volume":"18","author":"Chen Y. T.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1074-5521(00)00018-1","volume":"7","author":"Du X.","year":"2000","journal-title":"Chem. Biol."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/jmbi.1994.0137","volume":"247","author":"Mcgrath M. E.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/pro.5560060801","volume":"6","author":"Gillmor S. A.","year":"1997","journal-title":"Protein Sci."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/1521-4184(200205)335:5<183::AID-ARDP183>3.0.CO;2-U","volume":"335","author":"Mishra V.","year":"2002","journal-title":"Arch. Pharm."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0042-6822(91)90559-T","volume":"185","author":"Condit R. C.","year":"1991","journal-title":"Virology"},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0065-2571(98)00017-X","volume":"39","author":"Finch R. A.","year":"1999","journal-title":"Adv. Enzyme Regul."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/jm00193a020","volume":"22","author":"Klayman D. L.","year":"1979","journal-title":"J. Med. Chem."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1021\/jm00253a025","volume":"17","author":"Wilson H. R.","year":"1974","journal-title":"J. Med. Chem."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1021\/jm010459j","volume":"45","author":"Du X.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/jm030549j","volume":"47","author":"Greenbaum D. C.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bmcl.2004.10.023","volume":"15","author":"Fujii N.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1016\/j.bmcl.2008.03.083","volume":"18","author":"Mallari J. P.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1590\/S0103-50532001000300002","volume":"12","author":"da Silva J. F. M.","year":"2001","journal-title":"J. Braz. Chem. Soc."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0960-894X(94)00464-Q","volume":"5","author":"Iyer R. A.","year":"1995","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1021\/jm960603e","volume":"39","author":"Webber S. E.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1016\/S0960-894X(03)00756-X","volume":"13","author":"Chiyanzu I.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/scientificamerican0385-114","volume":"252","author":"Block E.","year":"1985","journal-title":"Sci. Am."},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1128\/AAC.41.10.2286","volume":"41","author":"Ankri S.","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1128\/AAC.50.5.1731-1737.2006","volume":"50","author":"Coppi A.","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0304-4165(97)00104-9","volume":"1379","author":"Rabinkov A.","year":"1998","journal-title":"Biochem. Biophys. Acta"},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1016\/j.bmcl.2010.07.062","volume":"20","author":"Waag T.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.phymed.2003.10.007","volume":"12","author":"Tempone A. G.","year":"2005","journal-title":"Phytomedicine"},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.3390\/molecules13092303","volume":"13","author":"Ma Z.-Z.","year":"2008","journal-title":"Molecules"},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/S0968-0896(03)00117-2","volume":"11","author":"Batra S.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1016\/j.bmc.2009.08.013","volume":"17","author":"Micale N.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"11473","DOI":"10.1073\/pnas.0604348103","author":"Inglese J.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref96\/cit96","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1021\/jm901069a","volume":"53","author":"Mott B. T.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref97\/cit97","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/cmdc.201000449","volume":"6","author":"Ehmke V.","year":"2011","journal-title":"ChemMedChem"},{"key":"ref98\/cit98","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/cmdc.201100189","volume":"6","author":"Langolf S.","year":"2011","journal-title":"ChemMedChem"},{"key":"ref99\/cit99","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/QCO.0b013e328315cca9","volume":"21","author":"McKerrow J. H.","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref100\/cit100a","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1046\/j.1365-2672.2000.01168.x","volume":"89","author":"Hasne M.-P.","year":"2000","journal-title":"J. Appl. Microbiol."},{"key":"ref100\/cit100b","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/978-0-387-77570-8_3","volume":"625","author":"Landfear S. M.","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.addr.2009.11.024","volume":"62","author":"Santos-Magalh\u00e3es N. S.","year":"2010","journal-title":"Adv. Drug Delivery Rev"},{"key":"ref102\/cit102","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.addr.2006.09.009","volume":"58","author":"Torchilin V. P.","year":"2006","journal-title":"Adv. Drug Delivery Rev."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm301424d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T06:04:12Z","timestamp":1681625052000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm301424d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":111,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2013,7,25]]}},"alternative-id":["10.1021\/jm301424d"],"URL":"https:\/\/doi.org\/10.1021\/jm301424d","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,7]]}}}