{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:01:54Z","timestamp":1791896514884,"version":"4.3.4"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2013,2,14]]},"DOI":"10.1021\/jm301581y","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T18:40:26Z","timestamp":1357756826000},"page":"879-894","source":"Crossref","is-referenced-by-count":185,"title":["Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region\u2013Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib"],"prefix":"10.1021","volume":"56","author":[{"given":"Xiaomei","family":"Ren","sequence":"first","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"},{"name":"Zhongshan\rMedical School, Sun Yat-Sen University,\r#74 Second Zhongshan Road,\rGuangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deping","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"},{"name":"Graduate University of Chinese Academy of Sciences, # 19 Yuquan Road, Beijing\r100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"},{"name":"Graduate University of Chinese Academy of Sciences, # 19 Yuquan Road, Beijing\r100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Wen","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huoyou","family":"Long","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Leng","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfen","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoqin","family":"She","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengchao","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Pan","sequence":"additional","affiliation":[{"name":"Zhongshan\rMedical School, Sun Yat-Sen University,\r#74 Second Zhongshan Road,\rGuangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute\rof Chemical Biology,\rGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou\r510530, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM200104053441402","volume":"344","author":"Druker B. J.","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","volume":"344","author":"Druker B. J.","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1634\/theoncologist.6-3-233","volume":"6","author":"Mauro M. J.","year":"2001","journal-title":"Oncologist"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJMoa011573","volume":"346","author":"Kantarjian H.","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"Druker B. J.","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1182\/blood.V114.22.1126.1126","volume":"114","author":"Deininger M.","year":"2009","journal-title":"Blood"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1182\/blood-2007-03-066936","volume":"110","author":"O\u2019Hare T.","year":"2007","journal-title":"Blood"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1535-6108(02)00096-X","volume":"2","author":"Shah N. P.","year":"2002","journal-title":"Cancer Cell"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1158\/0008-5472.CAN-05-0259","volume":"65","author":"O\u2019Hare T.","year":"2005","journal-title":"Cancer Res."},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","volume":"7","author":"Weisberg E.","year":"2005","journal-title":"Cancer Cell"},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1182\/blood-2007-03-080689","volume":"110","author":"Kantarjian H. M.","year":"2007","journal-title":"Blood"},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.1099480","volume":"305","author":"Shah N. P.","year":"2004","journal-title":"Science"},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1182\/blood-2006-07-035493","volume":"109","author":"Quintas-Cardama A.","year":"2007","journal-title":"Blood"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1182\/blood-2005-06-2209","volume":"106","author":"Kimura S.","year":"2005","journal-title":"Blood"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"11314","DOI":"10.1158\/0008-5472.CAN-06-1199","volume":"66","author":"Puttini M.","year":"2006","journal-title":"Cancer Res."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1182\/blood-2006-02-004580","volume":"108","author":"Bradeen H. A.","year":"2006","journal-title":"Blood"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1073\/pnas.0409770102","volume":"102","author":"Burgess M. R.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.blre.2011.09.001","volume":"25","author":"Roychowdhury S.","year":"2011","journal-title":"Blood Rev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1126\/science.289.5486.1938","volume":"289","author":"Schindler T.","year":"2000","journal-title":"Science"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1158\/0008-5472.CAN-05-4187","volume":"66","author":"Tokarski J. S.","year":"2006","journal-title":"Cancer Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1747-0285.2007.00556.x","volume":"70","author":"Zhou T.","year":"2007","journal-title":"Chem. Biol. Drug Des."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.1062538","volume":"293","author":"Gorre M. E.","year":"2001","journal-title":"Science"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0092-8674(03)00190-9","volume":"112","author":"Azam M.","year":"2003","journal-title":"Cell"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nsmb.1486","volume":"15","author":"Azam M.","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1182\/blood-2007-03-080838","volume":"110","author":"Cortes J.","year":"2007","journal-title":"Blood"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1172\/JCI30890","volume":"117","author":"Shah N. P.","year":"2007","journal-title":"J. Clin. Invest."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1200\/JCO.2006.08.9128","volume":"24","author":"Soverini S.","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref26\/cit26a","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/med.20175","volume":"31","author":"Schenone S.","year":"2011","journal-title":"Med. Res. Rev."},{"key":"ref26\/cit26b","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1016\/j.bmcl.2012.06.036","volume":"22","author":"Choi H. G.","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref26\/cit26c","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1747-0285.2007.00556.x","volume":"70","author":"Zhou T.","year":"2007","journal-title":"Chem. Biol. Drug Des."},{"key":"ref26\/cit26d","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1016\/j.bmcl.2007.08.043","volume":"17","author":"Cao J. G.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref26\/cit26e","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1073\/pnas.0408283102","volume":"102","author":"Gumireddy K.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref26\/cit26f","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nchembio760","volume":"2","author":"Adrian F. J.","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"ref26\/cit26g","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature08675","volume":"463","author":"Zhang J.","year":"2010","journal-title":"Nature"},{"key":"ref26\/cit26h","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/cmdc.201100304","volume":"11","author":"Arioli F.","year":"2011","journal-title":"ChemMedChem"},{"key":"ref27\/cit27a","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1182\/blood-2006-05-025049","volume":"109","author":"Giles F. J.","year":"2007","journal-title":"Blood"},{"key":"ref27\/cit27b","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2009.01.141","volume":"380","author":"Okabe S.","year":"2009","journal-title":"Biochem. Biophy. Res. Commun."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1182\/blood-2007-09-113175","volume":"111","author":"Gontarewicz A.","year":"2008","journal-title":"Blood"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1182\/blood-2009-03-211466","volume":"116","author":"Tanaka R.","year":"2010","journal-title":"Blood"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","unstructured":"Shah, N. P.; Kasap, C.; Paquette, R.; Cortes, J.; Pinilla, J.; Talpaz, M.; Bui, L. A.; Clary, D. O.Targeting drug-resistant CML and Ph+ all with the spectrum selective protein kinase inhibitor XL228. 49th ASH Annual Meeting, December 8\u201311, 2007, Atlanta, GA, Abstract 474.","DOI":"10.1182\/blood.V110.11.474.474"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2174\/156802608784911635","volume":"8","author":"Noronha G.","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.2174\/092986711795656135","volume":"18","author":"Lu X.","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1021\/jm8010542","volume":"52","author":"Bikker J. A.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref34\/cit34a","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ccr.2009.09.028","volume":"16","author":"O\u2019Hare T.","year":"2009","journal-title":"Cancer Cell"},{"key":"ref34\/cit34b","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1747-0285.2010.01054.x","volume":"77","author":"Zhou T.","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"ref34\/cit34c","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1021\/jm100395q","volume":"53","author":"Huang W.-S.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref35\/cit35a","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ccr.2011.03.003","volume":"19","author":"Chan W. W.","year":"2011","journal-title":"Cancer Cell"},{"key":"ref35\/cit35b","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1158\/0008-5472.CAN-10-3224","volume":"71","author":"Eide C. A.","year":"2011","journal-title":"Cancer Res."},{"key":"ref36\/cit36a","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/ml200025q","volume":"2","author":"Wenglowsky S.","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"ref36\/cit36b","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1016\/j.bmcl.2011.06.097","volume":"21","author":"Wenglowsky S.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref36\/cit36c","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1016\/j.bmcl.2012.08.007","volume":"22","author":"Wenglowsky S.","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref36\/cit36d","doi-asserted-by":"crossref","first-page":"10033","DOI":"10.1021\/jm301188x","volume":"55","author":"Li Y.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1021\/cr050992x","volume":"10","author":"Chinchilla R.","year":"2007","journal-title":"Chem. Rev."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1021\/jm201591k","volume":"55","author":"Chang S.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1182\/blood-2006-01-0092","volume":"108","author":"Hughes T.","year":"2006","journal-title":"Blood"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejca.2011.08.015","volume":"48","author":"Preuner S.","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1158\/1078-0432.CCR-06-1516","volume":"12","author":"Soverini S.","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1124\/dmd.104.000026","volume":"32","author":"McGinnity D. F.","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","DOI":"10.1201\/9781482272772","volume-title":"Cytochromes P450: Structure, Function and Mechanism","author":"Lewis D. F. V.","year":"1996"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1023\/A:1013358126640","volume":"18","author":"Adachi Y.","year":"2001","journal-title":"Pharm. Res."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","volume":"9","author":"Giacomini K. M.","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1182\/blood-2002-09-2896","volume":"102","author":"Branford S.","year":"2003","journal-title":"Blood"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1200\/JCO.2005.05.531","volume":"23","author":"Soverini S.","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1021\/jm060379l","volume":"49","author":"Jamieson C.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1359-6446(00)01602-0","volume":"6","author":"Netzer R.","year":"2001","journal-title":"Drug Discovery Today"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1182\/blood-2004-06-2445","volume":"105","author":"von Bubnoff N.","year":"2005","journal-title":"Blood"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1021\/ml100146z","volume":"1","author":"Ren X.","year":"2010","journal-title":"ACS Med. Chem. Lett."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm301581y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T23:41:39Z","timestamp":1681602099000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm301581y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,28]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,2,14]]}},"alternative-id":["10.1021\/jm301581y"],"URL":"https:\/\/doi.org\/10.1021\/jm301581y","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,28]]}}}