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L.","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/(SICI)1097-0282(20000415)53:5<434::AID-BIP7>3.0.CO;2-5","volume":"53","author":"Nakanishi I.","year":"2000","journal-title":"Bioploymers"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/bi00431a001","volume":"28","author":"Bode W.","year":"1989","journal-title":"Biochemistry"},{"key":"ref19\/cit19","first-page":"1904","volume":"48","author":"Reddel R. R.","year":"1988","journal-title":"Cancer Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","volume":"7","author":"Ley K.","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00202069","volume":"74","author":"van de Stolpe A.","year":"1996","journal-title":"J. Mol. Med."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/01.CIR.102.13.1549","volume":"102","author":"Labarrere C. A.","year":"2000","journal-title":"Circulation"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3109\/02770903.2011.604886","volume":"48","author":"Ciebiada M.","year":"2011","journal-title":"J. Asthma"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"35494","DOI":"10.1074\/jbc.M103543200","volume":"276","author":"Walsh D. E.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1007\/s10620-006-9178-1","volume":"51","author":"Ishihara K.","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.4049\/jimmunol.178.9.5871","volume":"178","author":"Geraghty P.","year":"2007","journal-title":"J. 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Immunol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1513\/pats.200402-009MS","volume":"1","author":"Jeffrey P. K.","year":"2004","journal-title":"Proc. Am. Thorac. Soc."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/icb.1990.14","volume":"68","author":"Mendis A. H. W.","year":"1990","journal-title":"Immunol. Cell Biol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000088436","volume":"138","author":"Trautman A.","year":"2005","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1165\/rcmb.F269","volume":"28","author":"Tuder R. M.","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1183\/09031936.00176807","volume":"32","author":"Drakopanagiotakis F.","year":"2008","journal-title":"Eur. Respir. J."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.4049\/jimmunol.161.11.6398","volume":"161","author":"Champagne B.","year":"1998","journal-title":"J. Immunol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/eji.200323195","volume":"33","author":"Robledo O.","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1189\/jlb.0106038","volume":"79","author":"Garton K. J.","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1172\/JCI115738","volume":"89","author":"Nakamura H.","year":"1992","journal-title":"J. Clin. Invest"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"L407","DOI":"10.1152\/ajplung.00471.2005","volume":"291","author":"Kuwahara I.","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1165\/rcmb.2004-0309OC","volume":"32","author":"Lappalainen U.","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.4049\/jimmunol.0803154","volume":"183","author":"Couillin I.","year":"2009","journal-title":"J. Immunol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/S0960-894X(02)00393-1","volume":"12","author":"Nakayama Y.","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/np800557m","volume":"72","author":"Okumura H. S.","year":"2009","journal-title":"J. Nat. 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