{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:32:17Z","timestamp":1761489137874},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2013,6,13]]},"DOI":"10.1021\/jm4000165","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T16:10:44Z","timestamp":1368634244000},"page":"4442-4455","source":"Crossref","is-referenced-by-count":22,"title":["Synthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2\/3 Receptor Agonists"],"prefix":"10.1021","volume":"56","author":[{"given":"James A.","family":"Monn","sequence":"first","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Valli","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Massey","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junliang","family":"Hao","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Bures","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly A.","family":"Heinz","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xushan","family":"Wang","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan H.","family":"Carter","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian G.","family":"Getman","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Herin","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Catlow","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Swanson","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan G.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"McKinzie","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Henry","sequence":"additional","affiliation":[{"name":"Discovery\rChemistry Research and Technologies, \u00a7Preformulation, \u2225Drug Disposition and \u22a5Neuroscience Research, Eli Lilly and Company, Indianapolis,\rIndiana 46285, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1358\/dof.2010.035.04.1487693","volume":"35","author":"O\u2019Neill M. J.","year":"2010","journal-title":"Drugs Future"},{"key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","volume":"50","author":"Niswender C. M.","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.neuropharm.2011.06.007","volume":"62","author":"Fell M. J.","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1007\/s00018-009-0130-3","volume":"66","author":"Moreno J. L.","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref2\/cit2c","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2009.12.041","volume":"639","author":"Chaki S.","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref2\/cit2d","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrd2462","volume":"7","author":"Sanacora G.","year":"2008","journal-title":"Nature Rev. Drug Discovery"},{"key":"ref2\/cit2e","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/187152707780363302","volume":"6","author":"Witkin J. M.","year":"2007","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref2\/cit2f","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/1025389031000146773","volume":"6","author":"Schoepp D. D.","year":"2003","journal-title":"Stress"},{"key":"ref3\/cit3a","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0091-3057(02)00849-3","volume":"73","author":"Simmons R. M. A.","year":"2002","journal-title":"Pharmacol., Biochem. Behav."},{"key":"ref3\/cit3b","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.neuroscience.2008.03.084","volume":"154","author":"Du J.","year":"2008","journal-title":"Neuroscience"},{"key":"ref3\/cit3c","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0014-2999(99)00397-0","volume":"377","author":"Kingston A. E.","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"ref3\/cit3d","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0028-3908(03)00146-1","volume":"45","author":"Battaglia G.","year":"2003","journal-title":"Neuropharmacology"},{"key":"ref3\/cit3e","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2004.06.005","volume":"1019","author":"Schiefer J.","year":"2004","journal-title":"Brain Res."},{"key":"ref3\/cit3f","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.nbd.2012.03.025","volume":"47","author":"Reiner A.","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref3\/cit3g","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1093\/cercor\/bhp317","volume":"20","author":"Garcia B. G.","year":"2010","journal-title":"Cereb. Cortex"},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1215\/S1152851704000961","volume":"7","author":"Arcella A.","year":"2005","journal-title":"Neuro-Oncology"},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.neuropharm.2008.06.064","volume":"55","author":"Ciceroni C.","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/sj.npp.1301531","volume":"33","author":"Dunayevich E.","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nm1632","volume":"13","author":"Patil S. T.","year":"2007","journal-title":"Nature Med."},{"key":"ref6\/cit6b","first-page":"833","volume":"11","author":"Mezler M.","year":"2010","journal-title":"Drugs"},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/jm9606756","volume":"40","author":"Monn J. A.","year":"1997","journal-title":"J. Med. Chem."},{"key":"ref7\/cit7b","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/jm980616n","volume":"42","author":"Monn J. A.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref7\/cit7c","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1021\/jm060917u","volume":"50","author":"Monn J. A.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1021\/jm040222y","volume":"48","author":"Dominguez C.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1523\/JNEUROSCI.0418-11.2011","volume":"31","author":"Ceolin L.","year":"2011","journal-title":"J. Neurosci."},{"key":"ref8\/cit8c","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuropharm.2012.02.023","volume":"66","author":"Hanna L.","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref8\/cit8d","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuropharm.2012.05.023","volume":"66","author":"Sanger H.","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1021\/op060225f","volume":"11","author":"Varie D. L.","year":"2007","journal-title":"Org. Process Res. Dev."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1021\/ol300516y","volume":"14","author":"Henry S. S.","year":"2012","journal-title":"Org. Lett."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.tetlet.2012.01.033","volume":"53","author":"Hao J.","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0028-3908(96)00160-8","volume":"36","author":"Schoepp D. D.","year":"1997","journal-title":"Neuropharmacology"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0169-328X(97)00277-5","volume":"53","author":"Wu S.","year":"1998","journal-title":"Mol. Brain Res."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1073\/pnas.0611577104","volume":"104","author":"Muto T.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref17\/cit17","unstructured":"Maestro,version 9.2;Schrodinger LLC:New York, 2011."},{"key":"ref18\/cit18","unstructured":"The PyMOL Molecular Graphics System,version 1.2r3;Schrodinger LLC,New York, 2011."},{"key":"ref19\/cit19","volume-title":"Structural Genomics Consortium","author":"Wernimont A. K.","year":"2011"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1124\/dmd.105.004978","volume":"33","author":"James J. K.","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"ref21\/cit21a","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1124\/jpet.106.110809","volume":"321","author":"Rorick-Kehn L. M.","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref21\/cit21b","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/dmd.30.1.27","volume":"30","author":"Johnson J. T.","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1023\/A:1018943613122","volume":"10","author":"Davies B.","year":"1993","journal-title":"Pharm. Res."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuropharm.2012.01.019","volume":"66","author":"Wright R. A.","year":"2013","journal-title":"Neuropharmacology"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm4000165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T14:33:41Z","timestamp":1680705221000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm4000165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,3]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6,13]]}},"alternative-id":["10.1021\/jm4000165"],"URL":"https:\/\/doi.org\/10.1021\/jm4000165","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,3]]}}}