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T.","year":"2007","journal-title":"IUBMB Life"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/bmb\/66.1.121","volume":"66","author":"Budka H.","year":"2003","journal-title":"Br. Med. Bull."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","volume":"8","author":"Haass C.","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00125-010-1715-y","volume":"53","author":"Cooper G. J.","year":"2010","journal-title":"Diabetologia"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0166-2236(00)01749-5","volume":"2","author":"Klein W. L.","year":"2001","journal-title":"Trends Neurosci."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2337\/diabetes.52.11.2759","volume":"52","author":"Zhao H. 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Med."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/418291a","volume":"418","author":"Lashuel H. A.","year":"2002","journal-title":"Nature"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/bi990438f","volume":"38","author":"Huang X.","year":"1999","journal-title":"Biochemistry"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1021\/pr1009096","volume":"10","author":"Virok D. P.","year":"2011","journal-title":"J. Proteome Res."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"e24909","DOI":"10.1371\/journal.pone.0024909","volume":"6","author":"Manzoni C.","year":"2011","journal-title":"PLoS One"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrd3050","volume":"9","author":"Aguzzi A.","year":"2010","journal-title":"Nat. Rev. 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Life Sci."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1056\/NEJMoa065644","volume":"356","author":"Dember L. M.","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1756285611404470","volume":"4","author":"Galimberti D.","year":"2011","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0140-6736(99)11419-3","volume":"355","author":"Soto C.","year":"2000","journal-title":"Lancet"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/nbt1009-874c","volume":"27","author":"Ratner M.","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1474-4422(11)70246-0","volume":"10","author":"Plant\u00e9-Bordeneuve V.","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/1531-8249(200010)48:4<567::AID-ANA3>3.0.CO;2-W","volume":"48","author":"Weiner H. L.","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nm0302-199b","volume":"8","author":"Birmingham K.","year":"2002","journal-title":"Nat. Med."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrd3842","volume":"11","author":"Mullard A.","year":"2012","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature09494","volume":"468","author":"Bodin K.","year":"2010","journal-title":"Nature"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1006\/jmbi.2000.3840","volume":"300","author":"Tagliavini F.","year":"2000","journal-title":"J. Mol. Biol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0014-5793(00)02380-2","volume":"487","author":"Forloni G.","year":"2001","journal-title":"FEBS Lett."},{"key":"ref43\/cit43","first-page":"23","volume":"9","author":"Forloni G.","year":"2009","journal-title":"Infect. Disord.: Drug Targets"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1039\/C0OB00303D","volume":"9","author":"Airoldi C.","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2165\/00003088-198815060-00001","volume":"15","author":"Saivin S.","year":"1988","journal-title":"Clin. Pharmacokinet."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"C539","DOI":"10.1152\/ajpcell.00047.2010","volume":"299","author":"Griffin M. O.","year":"2010","journal-title":"Am. J. Physiol.: Cell Physiol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","volume":"65","author":"Chopra I.","year":"2001","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/08959374980120011901","volume":"12","author":"Nelson M. L.","year":"1998","journal-title":"Adv. Dent. Res."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1471-4159.2005.03219.x","volume":"94","author":"Kraus R. L.","year":"2005","journal-title":"J. Neurochem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00894-004-0213-x","volume":"11","author":"Cosentino U.","year":"2005","journal-title":"J. Mol. Model."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1021\/js980181r","volume":"88","author":"Duarte H. A.","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1021\/ja00520a003","volume":"101","author":"Hughes L. J.","year":"1979","journal-title":"J. Am. Chem. Soc."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","volume":"54","author":"Sapadin A. N.","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bpc.2007.04.005","volume":"128","author":"Jin L.","year":"2007","journal-title":"Biophys. Chem."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2165\/00003495-197611010-00004","volume":"11","author":"Neuvonen P. J.","year":"1976","journal-title":"Drugs"},{"key":"ref56\/cit56","first-page":"1253","volume-title":"The Pharmacological Basis of Therapeutics","author":"Weinstein L.","year":"1970","edition":"4"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/000348948209100208","volume":"91","author":"Canalis R. F.","year":"1982","journal-title":"Ann. Otol., Rhinol., Laryngol."},{"key":"ref58\/cit58","first-page":"83","volume":"88","author":"Melsen F.","year":"1980","journal-title":"Acta Pathol. Microbiol. Scand., Sect. A"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S8756-3282(96)00210-4","volume":"19","author":"Mellibovsky L.","year":"1996","journal-title":"Bone"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2106\/00004623-198668050-00018","volume":"68","author":"Ayala A. G.","year":"1986","journal-title":"J. Bone Jt. Surg., Am. Vol."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0092-8674(00)00216-6","volume":"103","author":"Brodersen D. E.","year":"2000","journal-title":"Cell"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1182\/blood.V86.3.855.855","volume":"86","author":"Gianni L.","year":"1995","journal-title":"Blood"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1073\/pnas.92.7.2959","volume":"92","author":"Merlini G.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1126\/science.276.5315.1119","volume":"276","author":"Tagliavini F.","year":"1997","journal-title":"Science"},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/S0002-9440(10)65065-1","volume":"156","author":"Palha J. A.","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1073\/pnas.162195499","volume":"99","author":"Forloni G.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/362543a0","volume":"362","author":"Forloni G.","year":"1993","journal-title":"Nature"},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1523\/JNEUROSCI.5145-06.2007","volume":"27","author":"Fioriti L.","year":"2007","journal-title":"J. Neurosci."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/prot.21204","volume":"66","author":"Ronga L.","year":"2007","journal-title":"Proteins"},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbrc.2006.03.135","volume":"344","author":"Georgieva D.","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"e1888","DOI":"10.1371\/journal.pone.0001888","volume":"3","author":"De Luigi A.","year":"2008","journal-title":"PLoS One"},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.nbd.2010.07.002","volume":"40","author":"Diomede L.","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1532-5415.2004.52109.x","volume":"52","author":"Loeb M. B.","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/gps.3846","volume":"28","author":"Molloy D. W.","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1042\/bj20030422","volume":"374","author":"Aitken J. F.","year":"2003","journal-title":"Biochem. J."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1096\/fj.05-4652fje","volume":"20","author":"Malmo C.","year":"2006","journal-title":"FASEB J."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1096\/fj.02-0764com","volume":"17","author":"Cardoso I.","year":"2003","journal-title":"FASEB J."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1096\/fj.05-4509com","volume":"20","author":"Cardoso I.","year":"2006","journal-title":"FASEB J."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1479-5876-8-74","volume":"8","author":"Cardoso I.","year":"2010","journal-title":"J. Transl. Med."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/13506129.2012.678508","volume":"19","author":"Obici L.","year":"2012","journal-title":"Amyloid"},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1471-4159.2006.03707.x","volume":"97","author":"Ono K.","year":"2006","journal-title":"J. Neurochem."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"14669","DOI":"10.1073\/pnas.251341998","volume":"98","author":"Du Y.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/WNF.0b013e3181342f32","volume":"31","author":"NINDS NET-PD Investigators.","year":"2008","journal-title":"Clin. Neuropharmacol."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/77528","volume":"6","author":"Chen M.","year":"2000","journal-title":"Nat. Med."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ana.10614","volume":"54","author":"Smith D. L.","year":"2003","journal-title":"Ann. Neurol."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1385\/NMM:9:1:47","volume":"9","author":"Mievis S.","year":"2007","journal-title":"Neuromol. Med."},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/mds.23236","volume":"25","author":"Huntington Study Group DOMINO Investigators.","year":"2010","journal-title":"Mov. Disord."},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nm1242","volume":"11","author":"Davies J. E.","year":"2005","journal-title":"Nat. Med."},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1182\/blood-2011-04-351643","volume":"118","author":"Ward J. E.","year":"2011","journal-title":"Blood"},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jacc.2010.01.075","volume":"56","author":"Zheng H.","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1074\/jbc.M110.178376","volume":"286","author":"Giorgetti S.","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00894-008-0348-2","volume":"14","author":"Cosentino U.","year":"2008","journal-title":"J. Mol. Model."},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/bj3430419","volume":"343","author":"Howlett D. R.","year":"1999","journal-title":"Biochem. J."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1021\/ac702592f","volume":"80","author":"Inbar P.","year":"2008","journal-title":"Anal. Chem."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"8558","DOI":"10.1021\/ac101583q","volume":"82","author":"Zovo K.","year":"2010","journal-title":"Anal. Chem."},{"key":"ref96\/cit96","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1874609810801010030","volume":"1","author":"Galimberti D.","year":"2008","journal-title":"Curr. Aging Sci."},{"key":"ref97\/cit97","doi-asserted-by":"crossref","first-page":"735206","DOI":"10.1155\/2012\/735206","volume":"2012","author":"Ferreiro E.","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"ref98\/cit98","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12017-009-8102-1","volume":"11","author":"Bolognin S.","year":"2009","journal-title":"Neuromol. Med."},{"key":"ref99\/cit99","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/pmic.200900651","volume":"10","author":"Lim Y. A.","year":"2010","journal-title":"Proteomics"},{"key":"ref100\/cit100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4161\/pri.3.2.8820","volume":"3","author":"Noble W.","year":"2009","journal-title":"Prion"},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-4658.2010.07919.x","volume":"278","author":"Gialeli C.","year":"2011","journal-title":"FEBS J."},{"key":"ref102\/cit102","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.semcdb.2007.07.003","volume":"19","author":"Manicone A. M.","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref103\/cit103","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","volume":"69","author":"Nagase H.","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref104\/cit104","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1440-1797.2007.00845.x","volume":"13","author":"Naganuma T.","year":"2008","journal-title":"Nephrology (Carlton)"},{"key":"ref105\/cit105","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1096\/fj.04-2022fje","volume":"19","author":"Sousa M. M.","year":"2005","journal-title":"FASEB J."},{"key":"ref106\/cit106","first-page":"249","volume":"1","author":"Biolo A.","year":"2008","journal-title":"Circ.: Heart Failure"},{"key":"ref107\/cit107","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1474-4422(09)70016-X","volume":"8","author":"Rosenberg G. A.","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref108\/cit108","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1471-4159.2010.07082.x","volume":"116","author":"Kim E. M.","year":"2011","journal-title":"J. Neurochem."},{"key":"ref109\/cit109","doi-asserted-by":"crossref","first-page":"24566","DOI":"10.1074\/jbc.M602440200","volume":"281","author":"Yan P.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref110\/cit110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1471-4159.2008.05399.x","volume":"106","author":"Choi D. H.","year":"2008","journal-title":"J. Neurochem."},{"key":"ref111\/cit111","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1600-0765.1983.tb00388.x","volume":"18","author":"Golub L. M.","year":"1983","journal-title":"J. Periodontal Res."},{"key":"ref112\/cit112","first-page":"28","volume":"14","author":"Greenwald R. A.","year":"1987","journal-title":"J. Rheumatol."},{"key":"ref113\/cit113","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1749-6632.1994.tb24728.x","volume":"732","author":"Golub L. M.","year":"1994","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref114\/cit114","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/0929867013373598","volume":"8","author":"Ryan M. E.","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"ref115\/cit115","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1006588708131","volume":"16","author":"Seftor R. E.","year":"1998","journal-title":"Clin. Exp. Metastasis"},{"key":"ref116\/cit116","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1124\/mol.104.006346","volume":"67","author":"Garcia R. A.","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref117\/cit117","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/1529-0131(199906)42:6<1140::AID-ANR10>3.0.CO;2-7","volume":"42","author":"Smith G. N.","year":"1999","journal-title":"Arthritis Rheum."},{"key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.phrs.2010.10.003","volume":"63","author":"Golub L. M.","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref119\/cit119","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.phrs.2011.06.010","volume":"64","author":"Greenwald R. A.","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref120\/cit120","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.addr.2009.02.005","volume":"61","author":"Fang J.","year":"2009","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref121\/cit121","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1074\/jbc.M110.169565","volume":"286","author":"Schildknecht S.","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref122\/cit122","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuron.2011.07.001","volume":"71","author":"Kummer M. P.","year":"2011","journal-title":"Neuron"},{"key":"ref123\/cit123","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1523\/JNEUROSCI.21-19-07576.2001","volume":"21","author":"Sousa M. M.","year":"2001","journal-title":"J. Neurosci."},{"key":"ref124\/cit124","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1385\/NMM:5:2:147","volume":"5","author":"Manczak M.","year":"2004","journal-title":"Neuromol. Med."},{"key":"ref125\/cit125","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/1523-1747.ep12285793","volume":"86","author":"Miyachi Y.","year":"1986","journal-title":"J. Invest. Dermatol."},{"key":"ref126\/cit126","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2340\/0001555572178179","volume":"72","author":"Akamatsu H.","year":"1992","journal-title":"Acta Derm.-Venereol."},{"key":"ref127\/cit127","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jacc.2008.06.028","volume":"52","author":"Romero-Perez D.","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref128\/cit128","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12012-011-9107-1","volume":"11","author":"Zeydanli E. N.","year":"2011","journal-title":"Cardiovasc. Toxicol."},{"key":"ref129\/cit129","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejphar.2010.07.010","volume":"644","author":"Lai H. C.","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref130\/cit130","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4049\/jimmunol.176.1.567","volume":"176","author":"Hoyt J. C.","year":"2006","journal-title":"J. Immunol."},{"key":"ref131\/cit131","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.taap.2009.02.026","volume":"237","author":"Huang T. Y.","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref132\/cit132","doi-asserted-by":"crossref","first-page":"14014","DOI":"10.1073\/pnas.93.24.14014","volume":"93","author":"Amin A. R.","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref133\/cit133","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1128\/AAC.41.1.117","volume":"41","author":"Milano S.","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref134\/cit134","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1128\/AAC.47.11.3630-3633.2003","volume":"47","author":"Krakauer T.","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref135\/cit135","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1365-2249.2009.03949.x","volume":"157","author":"Lau A. C.","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"ref136\/cit136","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1067\/mva.2002.123757","volume":"35","author":"Prall A. K.","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"ref137\/cit137","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1161\/CIRCULATIONAHA.108.806505","volume":"119","author":"Lindeman J. H.","year":"2009","journal-title":"Circulation"},{"key":"ref138\/cit138","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s10067-008-0903-3","volume":"27","author":"Miyazaki E.","year":"2008","journal-title":"Clin. Rheumatol."},{"key":"ref139\/cit139","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jaad.2006.11.021","volume":"56","author":"Del Rosso J. Q.","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref140\/cit140","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1034\/j.1600-051x.2001.028002146.x","volume":"28","author":"Golub L. M.","year":"2001","journal-title":"J. Clin. Periodontol."},{"key":"ref141\/cit141","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2174\/187152010793498645","volume":"10","author":"Sagar J.","year":"2010","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref142\/cit142","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.1832501100","volume":"100","author":"Wang X.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref143\/cit143","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10863-010-9271-1","volume":"42","author":"Antonenko Y. N.","year":"2010","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref144\/cit144","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1126\/science.133.3447.196","volume":"133","author":"Du Buy H. G.","year":"1961","journal-title":"Science"},{"key":"ref145\/cit145","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/AAC.34.1.167","volume":"34","author":"Riesbeck K.","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref146\/cit146","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1177\/1087057110373547","volume":"15","author":"Nadanaciva S.","year":"2010","journal-title":"J. Biomol. Screening"},{"key":"ref147\/cit147","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jlb.46.2.128","volume":"46","author":"Van der Bogert C.","year":"1989","journal-title":"J. Leukocyte Biol."},{"key":"ref148\/cit148","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1476-5381.2010.00746.x","volume":"160","author":"Shieh J. M.","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref149\/cit149","first-page":"309","volume":"13","author":"Brown T. M.","year":"1970","journal-title":"Arthritis Rheum."},{"key":"ref150\/cit150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7326\/0003-4819-122-2-199501150-00012","volume":"122","author":"Paulus H. E.","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"ref151\/cit151","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/jnr.22791","volume":"90","author":"Ossola B.","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"ref152\/cit152","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S1474-4422(04)00937-8","volume":"3","author":"Yong V. W.","year":"2004","journal-title":"Lancet Neurol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm400161p","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T12:26:28Z","timestamp":1715257588000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm400161p"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,8]]},"references-count":152,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2013,8,8]]}},"alternative-id":["10.1021\/jm400161p"],"URL":"https:\/\/doi.org\/10.1021\/jm400161p","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,8]]}}}