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Physiol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1749-6632.1997.tb51709.x","volume":"813","author":"Kiyoshi M.","year":"1997","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref8\/cit8","first-page":"36","volume":"313","author":"Kawaguchi H.","year":"1995","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1096\/fasebj.12.12.1063","volume":"12","author":"Dubois R. N.","year":"1998","journal-title":"FASEB J."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.2174\/092986708785132915","volume":"15","author":"Cimino P. J.","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12035-009-8066-z","volume":"40","author":"Hein A. M.","year":"2009","journal-title":"Mol. 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T.","year":"1975","journal-title":"Circulation"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.molmed.2004.05.004","volume":"10","author":"Rigas B.","year":"2004","journal-title":"Trends Mol. Med."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1179\/135100002125000947","volume":"7","author":"Minamiyama Y.","year":"2002","journal-title":"Redox Rep."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1039\/a827331z","volume":"27","author":"Thatcher G. R. J.","year":"1998","journal-title":"Chem. Soc. Rev."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/BF00877117","volume":"8","author":"Torfg\u00e5rd K. E.","year":"1994","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/jm061371e","volume":"50","author":"Hulsman N.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1021\/jm050211k","volume":"48","author":"Vel\u00e1zquez C.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1016\/j.bmc.2007.05.009","volume":"15","author":"Vel\u00e1zquez C. A.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/jm00115a013","volume":"34","author":"Maragos C. M.","year":"1991","journal-title":"J. Med. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2174\/1568026054679380","volume":"5","author":"Keefer L. K.","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1021\/ja0391614","volume":"126","author":"Dutton A. S.","year":"2004","journal-title":"J. Am. Chem. 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Cancer."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1021\/jm00011a005","volume":"38","author":"Nagasawa H. T.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"12880","DOI":"10.1021\/ja031538i","volume":"126","author":"Saavedra J. E.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"16526","DOI":"10.1021\/ja106552p","volume":"132","author":"Andrei D.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1021\/jm9903850","volume":"43","author":"Saavedra J. E.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1016\/S0040-4039(01)00263-5","volume":"42","author":"Tang X.","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1073\/pnas.112202099","volume":"99","author":"Shafirovich V.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1021\/jm050151i","volume":"48","author":"Miranda K. M.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1021\/jf00022a004","volume":"40","author":"Andersen H. J.","year":"1992","journal-title":"J. Agric. Food Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0162-0134(83)80006-3","volume":"19","author":"Doyle M. P.","year":"1983","journal-title":"J. Inorg. Biochem."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0162-0134(00)80291-3","volume":"14","author":"Doyle M. P.","year":"1981","journal-title":"J. Inorg. Biochem."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1073\/pnas.1430507100","volume":"100","author":"Miranda K. M.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/jo00340a038","volume":"47","author":"Pryor W. A.","year":"1982","journal-title":"J. Org. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1021\/jf025924f","volume":"51","author":"Tang J.","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/abbi.1997.0565","volume":"351","author":"Wink D. A.","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1248\/cpb.46.373","volume":"46","author":"Kojima H.","year":"1998","journal-title":"Chem. Pharm. Bull."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0891-5849(02)00978-4","volume":"33","author":"Espey M. G.","year":"2002","journal-title":"Free Radical Biol. Med."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1365-2036.1997.00247.x","volume":"11","author":"Davies N. M.","year":"1997","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref54\/cit54","first-page":"1208","volume":"58","author":"Huang M.","year":"1998","journal-title":"Cancer Res."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1172\/JCI119651","volume":"100","author":"Williams C. S.","year":"1997","journal-title":"J. Clin. Invest."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1194\/jlr.R800042-JLR200","volume":"50","author":"Rouzer C. A.","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"27357","DOI":"10.1016\/S0021-9258(18)46993-1","volume":"269","author":"Kennedy T. A.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.abb.2005.07.012","volume":"442","author":"Lopez B. E.","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.abb.2007.06.017","volume":"465","author":"Lopez B. E.","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"14030","DOI":"10.1021\/bi0507478","volume":"44","author":"Shen B.","year":"2005","journal-title":"Biochemistry"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/00001648-199403000-00003","volume":"5","author":"Schreinemachers D. M.","year":"1994","journal-title":"Epidemiology"},{"key":"ref62\/cit62","first-page":"559","volume":"13","author":"Harris R. E.","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref63\/cit63","first-page":"3","volume":"30","author":"Fosslien E.","year":"2000","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1677\/erc.0.0080097","volume":"8","author":"Howe L. R.","year":"2001","journal-title":"Endocr.-Relat. Cancer"},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1096\/fj.02-1011com","volume":"17","author":"Pai R.","year":"2003","journal-title":"FASEB J."},{"key":"ref66\/cit66","first-page":"2047","volume":"51","author":"Fulton A. M.","year":"1991","journal-title":"Cancer Res."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/onc.2009.421","volume":"29","author":"Wang D.","year":"2009","journal-title":"Oncogene"},{"key":"ref68\/cit68","first-page":"207","volume":"7","author":"Trifan O. C.","year":"2003","journal-title":"Cell. Mol. Biol."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2174\/0929867003374336","volume":"7","author":"Leahy K. M.","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbcan.2003.09.003","volume":"1654","author":"Ruegg C.","year":"2004","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1026575610124","volume":"19","author":"Gately S.","year":"2000","journal-title":"Cancer Metastasis Rev."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1471-4906(01)02154-8","volume":"23","author":"Harris S. G.","year":"2002","journal-title":"Trends Immunol."},{"key":"ref73\/cit73","first-page":"2929","volume":"58","author":"Wilson K. T.","year":"1998","journal-title":"Cancer Res."},{"key":"ref74\/cit74","first-page":"715","volume":"2","author":"Chiarugi V.","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/med.20092","volume":"27","author":"Mocellin S.","year":"2007","journal-title":"Med. Res. Rev."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1021\/jm030192j","volume":"47","author":"Stoyanovsky D. A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.bcp.2009.06.104","volume":"78","author":"Nath N.","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/jnci\/93.4.266","volume":"93","author":"Hockel M.","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","volume":"4","author":"Gatenby R. A.","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.biocel.2007.03.021","volume":"39","author":"Gatenby R. A.","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jcb.20399","volume":"95","author":"Sirover M. A.","year":"2005","journal-title":"J. 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