{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:36:34Z","timestamp":1791221794869,"version":"4.1.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2013,6,13]]},"DOI":"10.1021\/jm400408r","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T17:03:53Z","timestamp":1368637433000},"page":"4671-4690","source":"Crossref","is-referenced-by-count":123,"title":["Synthesis and Biological Investigation of Coumarin Piperazine (Piperidine) Derivatives as Potential Multireceptor Atypical Antipsychotics"],"prefix":"10.1021","volume":"56","author":[{"given":"Yin","family":"Chen","sequence":"first","affiliation":[{"name":"Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minquan","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinli","family":"Qiu","sequence":"additional","affiliation":[{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,5,31]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.pharmtox.010909.105851","volume":"51","author":"Ibrahim H. M.","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/schbul\/9.3.368","volume":"9","author":"Lewine R. R. J.","year":"1983","journal-title":"Schizophr. Bull."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0920-9964(91)90027-O","volume":"4","author":"Marde S. R.","year":"1991","journal-title":"Schizophr. Res."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.ne.03.030180.000323","volume":"3","author":"Baldessarini R. J.","year":"1980","journal-title":"Annu. Rev. Neurosci."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0306-4530(78)90001-X","volume":"3","author":"Boyd A. E.","year":"1978","journal-title":"Psychoneuroendocrinology"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1136\/bmj.321.7273.1371","volume":"321","author":"Geddes J.","year":"2000","journal-title":"BMJ"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.neuropharm.2008.05.025","volume":"55","author":"Jones C. A.","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/sj.npp.1300203","volume":"28","author":"Shapiro D.","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref9\/cit9","first-page":"17","volume":"174","author":"Roth B. L.","year":"2004","journal-title":"Psychopharmacology"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.pnpbp.2003.09.010","volume":"27","author":"Meltzer H. Y.","year":"2003","journal-title":"Prog. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF02245602","volume":"124","author":"Kinon B. J","year":"1996","journal-title":"Psychopharmacology"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2165\/00023210-200317110-00003","volume":"17","author":"Moller H. J.","year":"2003","journal-title":"CNS Drugs"},{"key":"ref13\/cit13","first-page":"531","volume":"8","author":"Vohora D.","year":"2007","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"ref14\/cit14","first-page":"1821","volume":"75","author":"Schultz S. H.","year":"2007","journal-title":"Am. Fam. Physician"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coph.2003.09.010","volume":"4","author":"Meltzer H. Y.","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2174\/138161209787315594","volume":"15","author":"Morphy R.","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2010.02.001","volume":"126","author":"Wong E. H.","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.tips.2008.07.001","volume":"29","author":"King M. V.","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbr.2008.02.023","volume":"195","author":"Ogren S. O.","year":"2008","journal-title":"Behav. Brain Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1021\/cr078224o","volume":"108","author":"Nichols D. E.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pharmthera.2007.05.004","volume":"115","author":"Lameh J.","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1021\/jm800689g","volume":"52","author":"Butini S.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/7854_2010_47","volume":"4","author":"Kim D. H.","year":"2010","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0022-3565(25)20710-8","volume":"251","author":"Meltzer H. Y.","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1021\/cr050263h","volume":"107","author":"Zhang A.","year":"2007","journal-title":"Chem. Rev."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0074-7742(08)60573-5","volume":"35","author":"Sibley D. R.","year":"1993","journal-title":"Int. Rev. Neurobiol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/S1471-1931(00)00025-2","volume":"23","author":"Sealfon S. C.","year":"2000","journal-title":"Trends Neurosci."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0028-3908(03)00145-X","volume":"45","author":"Leriche L.","year":"2003","journal-title":"Neuropharmacology"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0022-3565(24)39184-0","volume":"294","author":"Reavill C.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0149-7634(01)00023-9","volume":"5","author":"Richtand N. M","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00213-004-2096-z","volume":"179","author":"Laszy J.","year":"2005","journal-title":"Psychopharmacology"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1017\/S1092852900025098","volume":"9","author":"Meltzer H. Y.","year":"2004","journal-title":"CNS Spectrosc."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nm875","volume":"9","author":"B\u00e9zard E.","year":"2003","journal-title":"Nat. Med."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1124\/jpet.107.134536","volume":"324","author":"Millan M. J.","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","volume":"28","author":"Kroeze W. K.","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1073\/pnas.0611417104","volume":"104","author":"Kim S. F.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.bjp.0702350","volume":"126","author":"Reavill C.","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0028-3908(01)00054-5","volume":"41","author":"Wood M. D.","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1176\/appi.ajp.162.3.613","volume":"162","author":"Buckland P. R.","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1359786806066040","volume":"20","author":"Reynolds G. P.","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bmcl.2006.10.036","volume":"17","author":"Garzya V.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1016\/j.bmc.2008.06.030","volume":"16","author":"Ablordeppey S. Y.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.bmc.2010.01.040","volume":"18","author":"Neves G.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"e35186","DOI":"10.1371\/journal.pone.0035186","volume":"7","author":"Chen Y.","year":"2012","journal-title":"PLoS One"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0960-894X(02)00933-2","volume":"13","author":"Gonz\u00e1lez-G\u00f3mez J. C.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1016\/S0960-894X(98)00646-5","volume":"8","author":"Ter\u00e1n C.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1021\/jm9010127","volume":"52","author":"Pisani L.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"8862","DOI":"10.1021\/ja049684r","volume":"126","author":"Zhou Z.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0968-0896(02)00454-6","volume":"11","author":"Singh I.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0223-5234(02)01357-0","volume":"37","author":"Santana L.","year":"2002","journal-title":"Eur. J. Med. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0022-5347(05)67709-9","volume":"163","author":"Lepor H.","year":"2000","journal-title":"J. Urol."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1248\/bpb.22.457","volume":"22","author":"Takata Y.","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.286.5437.105","volume":"286","author":"Hertel P.","year":"1999","journal-title":"Science"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/med.20019","volume":"25","author":"Recanatini M.","year":"2005","journal-title":"Med. Res. Rev."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0166-4328(98)00122-3","volume":"100","author":"Kim H. S.","year":"1999","journal-title":"Behav. Brain Res."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/jm0309811","volume":"47","author":"Campiani G.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1192\/bjp.179.6.503","volume":"179","author":"Xiberas X.","year":"2001","journal-title":"Br. J. Psychiatry"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/14756360400002015","volume":"20","author":"Yee S. W.","year":"2005","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ejmech.2009.11.023","volume":"45","author":"Frecentese F.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01993161","volume":"33","author":"Dini S.","year":"1991","journal-title":"Agents Actions"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1016\/j.bmc.2005.12.009","volume":"14","author":"Betti L.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/1439-7633(20020503)3:5<455::AID-CBIC455>3.0.CO;2-L","volume":"3","author":"Roche O.","year":"2002","journal-title":"ChemBioChem"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.bjp.0702751","volume":"128","author":"Porter R. H.","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"15175","DOI":"10.1074\/jbc.270.25.15175","volume":"270","author":"Offermanns S.","year":"1995","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm400408r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T10:11:08Z","timestamp":1746007868000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm400408r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,31]]},"references-count":64,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6,13]]}},"alternative-id":["10.1021\/jm400408r"],"URL":"https:\/\/doi.org\/10.1021\/jm400408r","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,31]]}}}