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Dis."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0014-4894(91)90006-I","volume":"73","author":"Bonaldo M. C.","year":"1991","journal-title":"Exp. Parasitol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1017\/S0031182000066622","volume":"112","author":"Lowndes C. M.","year":"1996","journal-title":"Parasitology"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1128\/IAI.71.10.5739-5749.2003","volume":"71","author":"Cuevas J.","year":"2003","journal-title":"Infect. Immun."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.hepres.2003.09.002","volume":"28","author":"Nogueira de Melo A. C.","year":"2004","journal-title":"Hepatol. Res."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/BJ20060973","volume":"401","author":"Niemirowicz G.","year":"2007","journal-title":"Biochem. J."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2958.2008.06444.x","volume":"70","author":"Niemirowicz G.","year":"2008","journal-title":"Mol. Microbiol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2174\/157340810794578506","volume":"6","author":"Capaci-Rodrigues G.","year":"2010","journal-title":"Curr. Enzyme Inhib."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.exppara.2010.01.023","volume":"125","author":"Nogueira de Melo A. C.","year":"2010","journal-title":"Exp. Parasitol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/S0277-5387(00)00453-8","volume":"19","author":"Farkas E.","year":"2000","journal-title":"Polyhedron."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.2174\/0929867023369402","volume":"9","author":"Muri E. M.","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ccr.2007.08.001","volume":"252","author":"Codd R.","year":"2008","journal-title":"Coord. Chem. Rev."},{"key":"ref24\/cit24","first-page":"137","volume":"103","author":"Verma R. P.","year":"2012","journal-title":"EXS"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio V.","year":"2012","journal-title":"Chem. Rev."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1081\/SCC-100105879","volume":"31","author":"Rodrigues R. C.","year":"2001","journal-title":"Synth. Commun."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1021\/jm020183v","volume":"45","author":"Pirrung M. C.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1016\/j.bmc.2003.08.007","volume":"11","author":"Basappa M.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1016\/j.bmcl.2004.05.012","volume":"14","author":"Basappa M.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1016\/j.bmcl.2004.04.037","volume":"14","author":"Weidner-Wells M.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1016\/j.bmc.2006.02.043","volume":"14","author":"Andr\u00e9s J. I.","year":"2006","journal-title":"Bioorg. Med. 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Soc."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1039\/P19750000846","volume":"9","author":"Devlin J. P.","year":"1975","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1016\/j.bmc.2007.07.044","volume":"15","author":"Abdel-Hamid M. K.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00436-006-0126-y","volume":"99","author":"Rol\u00f3n M.","year":"2006","journal-title":"Parasitol. Res."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah R. G.","year":"1971","journal-title":"J. Biol. Chem."},{"key":"ref41\/cit41","first-page":"874","volume":"67","author":"Petroianu G. 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