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Chem."},{"key":"ref12\/cit12b","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1021\/jm3003872","volume":"55","author":"Yin L.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2174\/1568026611313120003","volume":"13","author":"Cerny M. A.","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1210\/me.2012-1287","volume":"27","author":"Strushkevich N.","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.mce.2003.10.027","volume":"217","author":"Bureik M.","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref16\/cit16","first-page":"946","volume":"41","author":"Weindel K.","year":"1991","journal-title":"Arzneimittelforschung"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0022-4731(88)90145-8","volume":"30","author":"Viger A.","year":"1988","journal-title":"J. Steroid Biochem."},{"key":"ref18\/cit18a","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0223-5234(94)90040-X","volume":"29","author":"Soll R. M.","year":"1994","journal-title":"Eur. J. Med. Chem."},{"key":"ref18\/cit18b","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/ardp.200400872","volume":"337","author":"Voets M.","year":"2004","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"ref19\/cit19a","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1515\/BC.2005.077","volume":"386","author":"Bureik M.","year":"2005","journal-title":"Biol. Chem."},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10822-007-9128-9","volume":"21","author":"Roumen L.","year":"2007","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1021\/jm00035a007","volume":"37","author":"Hartmann R. W.","year":"1994","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21a","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/cmdc.201000065","volume":"5","author":"Hu Q.","year":"2010","journal-title":"ChemMedChem."},{"key":"ref21\/cit21b","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1021\/jm100400a","volume":"53","author":"Hu Q.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21c","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ardp.200700251","volume":"341","author":"Pinto-Bazurco Mendieta M. A. E.","year":"2008","journal-title":"Arch. Pharm. 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E.","year":"1987","journal-title":"Steroids"},{"key":"ref24\/cit24a","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1210\/jcem-69-4-896","volume":"69","author":"Lamberts S. W.","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref24\/cit24b","first-page":"1162","volume":"70","author":"Demers L. M.","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1161\/CIRCULATIONAHA.104.521625","volume":"111","author":"Fiebeler A.","year":"2005","journal-title":"Circulation"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/01.hjh.0000226205.65442.f2","volume":"24","author":"M\u00e9nard J.","year":"2006","journal-title":"J. Hypertens."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1210\/en.2007-0584","volume":"149","author":"Minnaard-Huiban M.","year":"2008","journal-title":"Endocrinology"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/eurheartj\/ehn277","volume":"29","author":"Mulder P.","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ki.2009.9","volume":"75","author":"Lea W. B.","year":"2009","journal-title":"Kidney Int."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1124\/jpet.110.167148","volume":"334","author":"Rigel D. F.","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1097\/HJH.0b013e32833c2197","volume":"28","author":"Gamliel-Lazarovich A.","year":"2010","journal-title":"J. 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WO2010130796, 2010."},{"key":"ref80\/cit80","unstructured":"Aebi, J.; Amrein, K.; Chen, W.; Kuhn, B.; Liu, Y.; Maerki, H. P.; Mayweg, A. V.; Mohr, P.; Tan, X.; Wang, Z.; Zhou, M.New bicyclic dihydroisoquinoline-1-one derivatives. WO2013079452, 2013."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bmcl.2010.11.040","volume":"21","author":"Zimmer C.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1021\/jm301844q","volume":"56","author":"Gobbi S.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2174\/156802608784911590","volume":"8","author":"Gobbi S.","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"ref84\/cit84a","doi-asserted-by":"crossref","first-page":"13958","DOI":"10.3390\/ijms140713958","volume":"14","author":"Yin L.","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref84\/cit84b","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrurol.2013.274","volume":"11","author":"Yin L.","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"ref84\/cit84c","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1016\/j.ejmech.2009.01.002","volume":"44","author":"Hille U. E.","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref84\/cit84d","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.bmc.2007.10.094","volume":"16","author":"Jagusch C.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref85\/cit85a","doi-asserted-by":"crossref","first-page":"7080","DOI":"10.1021\/jm3004637","volume":"55","author":"Hu Q.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref85\/cit85b","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1021\/jm400484p","volume":"56","author":"Pinto-Bazurco Mendieta M. A. E.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1021\/jm100317b","volume":"53","author":"Hu Q.","year":"2010","journal-title":"J. Med. Chem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm401430e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T13:34:26Z","timestamp":1682170466000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm401430e"}},"subtitle":["Miniperspective"],"short-title":[],"issued":{"date-parts":[[2014,1,24]]},"references-count":109,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,6,26]]}},"alternative-id":["10.1021\/jm401430e"],"URL":"https:\/\/doi.org\/10.1021\/jm401430e","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,24]]}}}