{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:59:02Z","timestamp":1761947942145},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2014,4,10]]},"DOI":"10.1021\/jm401735w","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T15:45:24Z","timestamp":1394466324000},"page":"2895-2907","source":"Crossref","is-referenced-by-count":35,"title":["1,2,3,4,8,9,10,11-Octahydrobenzo[<i>j<\/i>]phenanthridine-7,12-diones as New Leads against <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1021","volume":"57","author":[{"given":"Davie","family":"Cappoen","sequence":"first","affiliation":[{"name":"Service Immunology, O.D. Communicable & Infectious Diseases, Scientific Institute of Public Health (Site Ukkel), Engelandstraat 642, B-1180 Ukkel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Claes","sequence":"additional","affiliation":[{"name":"Department\rof Sustainable Organic Chemistry and Technology, Faculty of Bioscience\rEngineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department\rof Sustainable Organic Chemistry and Technology, Faculty of Bioscience\rEngineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roel","family":"Anthonissen","sequence":"additional","affiliation":[{"name":"Service\rToxicology, O.D. Public Health and Surveillance, Scientific Institute\rof Public Health (Site Elsene), J. Wytsmanstraat 14, B-1050 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Mathys","sequence":"additional","affiliation":[{"name":"Program Tuberculosis and Mycobacteria, Service Bacterial Diseases, O.D. Communicable & Infectious Diseases, Scientific Institute of Public Health (Site Ukkel), Engelandstraat 642, B-1180 Ukkel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Verschaeve","sequence":"additional","affiliation":[{"name":"Service\rToxicology, O.D. Public Health and Surveillance, Scientific Institute\rof Public Health (Site Elsene), J. Wytsmanstraat 14, B-1050 Brussels, Belgium"},{"name":"Department\rof Biomedical Sciences, Antwerp University, Universiteitsplein 1, B-2610 Wilrijk, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Huygen","sequence":"additional","affiliation":[{"name":"Service Immunology, O.D. Communicable & Infectious Diseases, Scientific Institute of Public Health (Site Ukkel), Engelandstraat 642, B-1180 Ukkel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert De","family":"Kimpe","sequence":"additional","affiliation":[{"name":"Department\rof Sustainable Organic Chemistry and Technology, Faculty of Bioscience\rEngineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2014,3,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4614-6111-1_4","volume":"783","author":"Bher M. A.","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mib.2012.11.007","volume":"16","author":"Russel D.","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1371\/journal.pone.0052841","volume":"7","author":"Blouin Y.","year":"2012","journal-title":"PLoS One"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature09657","volume":"469","author":"Koul A.","year":"2011","journal-title":"Nature"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0952-7915(03)00075-X","volume":"15","author":"Flynn J. L.","year":"2003","journal-title":"Curr. Opin. Immunol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1574-6968.1994.tb07194.x","volume":"123","author":"Jarlier V.","year":"1994","journal-title":"FEMS Microbiol. Lett."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1128\/iai.61.7.2763-2773.1993","volume":"61","author":"McDonough K. A.","year":"1993","journal-title":"Infect. Immun."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.20030846","volume":"198","author":"Schnappinger D.","year":"2003","journal-title":"JEM"},{"key":"ref9\/cit9","first-page":"195","volume":"4","author":"Rattan A.","year":"1998","journal-title":"PMC"},{"key":"ref10\/cit10","first-page":"380","volume":"13","author":"Shah S. N.","year":"2007","journal-title":"PMC"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1378\/chest.08-2427","volume":"136","author":"Velayati A. A.","year":"2009","journal-title":"CHEST."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(06)69573-1","volume":"4","author":"Gandi N. R.","year":"2006","journal-title":"Lancet"},{"key":"ref13\/cit13","volume-title":"Treatment of tuberculosis: Guidelines for national programmes","year":"2009","edition":"4"},{"key":"ref14\/cit14","first-page":"1009","volume":"163","author":"Corbett E. L.","year":"2003","journal-title":"JAMA."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejmech.2011.11.033","volume":"48","author":"Cappoen D.","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1039\/P19910000555","author":"Valderrama J. A.","year":"1991","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"10172","DOI":"10.1016\/j.bmc.2008.10.064","volume":"16","author":"Valderrama J. A.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref17\/cit17c","doi-asserted-by":"crossref","first-page":"11616","DOI":"10.3390\/molecules171011616","volume":"17","author":"Iribarra J.","year":"2012","journal-title":"Molecules"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1055\/s-2006-950254","volume":"17","author":"Valderrama J. A.","year":"2006","journal-title":"Synlett"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1016\/j.tetlet.2004.04.123","volume":"45","author":"Collet S. C.","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"ref20\/cit20a","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1016\/S0040-4039(98)01683-9","author":"Kobayashi K.","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"ref20\/cit20b","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1039\/b106933k","author":"Kobayashi K.","year":"2001","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1016\/j.tet.2010.07.012","volume":"66","author":"Claes P.","year":"2010","journal-title":"Tetrahedron"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1016\/S0040-4039(00)01313-7","author":"Kobayashi K.","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"ref24\/cit24","author":"Claes P.","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1128\/IAI.67.9.4586-4593.1999","volume":"67","author":"Snewin V. A.","year":"1999","journal-title":"Infect. Immun."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejmech.2011.12.035","volume":"49","author":"Forge D.","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejmech.2013.03.023","volume":"63","author":"Cappoen D.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejmech.2013.06.010","volume":"67","author":"Claes P.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nprot.2008.75","volume":"3","author":"Repetto G.","year":"2008","journal-title":"Nat. Protoc."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1365-2249.2003.02171.x","volume":"133","author":"Lopez B.","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.vetmic.2011.02.030","volume":"151","author":"Hotter G. S.","year":"2012","journal-title":"Vet. Microbiol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S0037-86822012000300027","volume":"45","author":"Cortez-Escalante J. J.","year":"2012","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/1040841X.2011.638273","volume":"38","author":"Chiodini R. J.","year":"2012","journal-title":"Crit. Rev. Microbiol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.4161\/hv.7.11.17751","volume":"7","author":"Einarsdottir T.","year":"2012","journal-title":"Hum. Vaccines"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1128\/JCM.37.3.748-752.1999","volume":"37","author":"Hanna B. A.","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1128\/iai.64.3.683-690.1996","volume":"64","author":"Fenton M.","year":"1996","journal-title":"Infect. Immun."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/(SICI)1098-2280(1999)33:3<240::AID-EM8>3.0.CO;2-R","volume":"33","author":"Verschaeve L.","year":"1999","journal-title":"Environ. Mol. Mutagen."},{"key":"ref38\/cit38","first-page":"113","volume":"1","author":"Westerink W. M.","year":"2009","journal-title":"Environ. Mutagen."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","volume":"35","author":"Tice R. R.","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/ja00885a021","volume":"85","author":"Stork G.","year":"1963","journal-title":"J. Am. Chem. Soc."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ol036284k","volume":"6","author":"Evano G.","year":"2004","journal-title":"Org. Lett."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm401735w","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T10:13:31Z","timestamp":1680948811000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm401735w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,21]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,4,10]]}},"alternative-id":["10.1021\/jm401735w"],"URL":"https:\/\/doi.org\/10.1021\/jm401735w","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,21]]}}}