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A.","year":"1983","journal-title":"Biochemistry"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.2174\/092986708785747517","volume":"15","author":"Wardle N. J.","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1021\/jm200587f","volume":"54","author":"Mucha A.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref29\/cit29","unstructured":"Choidas, A.; Backes, A.; Cotten, M.; Engkvist, O.; Felber, B.; Freisleben, A.; Gold, K.; Greff, Z.; Habenberger, P.; Hafenbradl, D.; Hartung, C.; Herget, T.; Hoppe, E.; Klebl, B.; Missio, A.; M\u00fcller, G.; Schwab, W.; Zech, B.; Bravo, J.; Harris, J.; Le, J.; Macritchie, J.Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases. PCT Int. Appl. WO 2005026129, 2005"},{"key":"ref29\/ref29_2","first-page":"336376","volume":"142","year":"2005","journal-title":"Chem. 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