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Lett."},{"key":"ref10\/cit10a","first-page":"64","volume-title":"Chemotherapy and Drug Resistance in Malaria","author":"Peters W.","year":"1970"},{"key":"ref10\/cit10b","unstructured":"bIn vivo test procedure: The colony bred Swiss mice of either sex (20 \u00b1 2g) were inoculated intraperitoneally with 1 \u00d7 106parasitized RBCs on day 0, and treatment was administered to a group of five mice at each dose from day 0 to day 3, once daily. The drug dilutions of compounds9,11,12a\u2013g,13a\u2013g,14a\u2013g, and15a\u2013cwere prepared in groundnut oil to contain the required amount of the drug (0.3 mg for a dose of 24 mg\/kg, 0.15 mg for a dose of 12 mg\/kg, 0.075 mg for a dose of 6 mg\/kg, and 0.0375 mg) in 0.1 mL and administered orally and intramuscularly for each required dose. Parasitemia levels were recorded from thin blood smears on day 4 and subsequently twice a week till day 28.(14)The treated mice surviving beyond day 28 were recorded as mice protected by the drug. Mice treated with \u03b2-arteether served as positive control."},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1021\/jm060826x","volume":"49","author":"Singh C.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.bmcl.2007.12.074","volume":"18","author":"Singh C.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1021\/jm0610043","volume":"50","author":"Singh C.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13a","unstructured":"a100% suppression of parasitemia means no parasites were detected in 50 oil immersion microscopic fields; parasites if at all present were below the detection limit. The parasites present below the detection limit could multiply and eventually could be detected during observation on subsequent days. In such cases though the drug was providing near 100% suppression of the parasitemia on day 4, it would not provide full protection to the treated mice in the 28-day survival assay. Multidrug-resistantPlasmodium yoelii nigeriensisused in this study is resistant to chloroquine, mefloquine, and halofantrine."},{"key":"ref13\/cit13b","unstructured":"b100% protection means that all the treated mice survived till day 28. Similarly 60% protection means three out of five treated mice survived till day 28."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/expr.1999.4465","volume":"94","author":"Puri S. K.","year":"2000","journal-title":"Exp. 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