{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:56:39Z","timestamp":1791143799237,"version":"4.1.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2014,5,22]]},"DOI":"10.1021\/jm401989c","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T15:55:10Z","timestamp":1398700510000},"page":"4073-4087","source":"Crossref","is-referenced-by-count":26,"title":["Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor"],"prefix":"10.1021","volume":"57","author":[{"given":"Takeru","family":"Kudo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyasu","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department\rof Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nakabayashi","sequence":"additional","affiliation":[{"name":"Department\rof Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department\rof Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tokiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teikichi","family":"Ikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Makishima","sequence":"additional","affiliation":[{"name":"Department\rof Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department\rof Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,7]]},"reference":[{"issue":"2","key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"V16","DOI":"10.1359\/jbmr.07s207","volume":"22","author":"Pike J. W.","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"Lacey D. L.","year":"1998","journal-title":"Cell"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrd2620","volume":"7","author":"Yasothan U.","year":"2008","journal-title":"Nature Rev. Drug Discovery"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrd3299","volume":"10","author":"Kawai M.","year":"2011","journal-title":"Nature Rev. Drug Discovery"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.2146\/ajhp100493","volume":"68","author":"Chitre M.","year":"2011","journal-title":"Am. J. Health-Syst. Pharm."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","volume":"361","author":"Cummings S. R.","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1210\/en.2006-0403","volume":"147","author":"Xue Y.","year":"2006","journal-title":"Endocrinology"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.2174\/138955709789957486","volume":"9","author":"Kubodera N.","year":"2009","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"13487","DOI":"10.1073\/pnas.202471299","volume":"99","author":"Shevde N. K.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s00198-005-0036-3","volume":"17","author":"Plum L. A.","year":"2006","journal-title":"Osteoporosis Int."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jbmr.256","volume":"26","author":"DeLuca H. F.","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI25901","volume":"116","author":"Ma Y.","year":"2006","journal-title":"J. Clin. Invest."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0092-8674(00)81717-1","volume":"95","author":"Shiau A. K.","year":"1998","journal-title":"Cell"},{"key":"ref13\/cit13a","doi-asserted-by":"crossref","first-page":"20333","DOI":"10.1074\/jbc.M111.308403","volume":"287","author":"Lusher S. J.","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref13\/cit13b","doi-asserted-by":"crossref","first-page":"35079","DOI":"10.1074\/jbc.M111.273029","volume":"286","author":"Lusher S. J.","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref14\/cit14a","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.abb.2006.11.026","volume":"460","author":"Igarashi M.","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref14\/cit14b","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1124\/mol.106.032318","volume":"71","author":"Inaba Y.","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"ref14\/cit14c","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1021\/jm8004477","volume":"51","author":"Nakabayashi M.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref14\/cit14d","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1124\/mol.106.032318","volume":"71","author":"Inaba Y.","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"ref15\/cit15a","first-page":"469","volume":"8","author":"Itsuno S.","year":"1983","journal-title":"J. Chem. Soc.: Chem. Commun."},{"key":"ref15\/cit15b","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1021\/ja00252a056","volume":"109","author":"Corey E. J.","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"ref15\/cit15c","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1002\/(SICI)1521-3773(19980817)37:15<1986::AID-ANIE1986>3.0.CO;2-Z","volume":"37","author":"Corey E. J.","year":"1998","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref15\/cit15d","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1021\/jo9612943","volume":"61","author":"Bach J.","year":"1996","journal-title":"J. Org. Chem."},{"key":"ref16\/cit16a","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1021\/ja00011a006","volume":"113","author":"Ohtani I.","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"ref16\/cit16b","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1016\/0040-4039(91)80650-U","volume":"32","author":"Kusumi T.","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.bmc.2006.10.069","volume":"15","author":"Kobayashi E.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1194\/jlr.M700293-JLR200","volume":"49","author":"Ishizawa M.","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref19\/cit19","first-page":"5907","volume":"13","author":"MacDonald P. N.","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1124\/mol.111.074138","volume":"80","author":"Choi M.","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"12101","DOI":"10.1074\/jbc.273.20.12101","volume":"273","author":"Onate S. A.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"40463","DOI":"10.1074\/jbc.M007864200","volume":"275","author":"Underhill C.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1073\/pnas.96.7.3519","volume":"96","author":"Park E. J.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1073\/pnas.90.10.4543","volume":"90","author":"Chen K. S.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","volume":"311","author":"Liu P. T.","year":"2006","journal-title":"Science"},{"key":"ref26\/cit26a","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1006\/bbrc.2000.3716","volume":"278","author":"Peng J. B.","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref26\/cit26b","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1472-6793-1-11","volume":"1","author":"Wood R. J.","year":"2001","journal-title":"BMC Physiol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"53602","DOI":"10.1074\/jbc.M409778200","volume":"279","author":"Wu Q.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref28\/cit28a","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.1016\/j.bmc.2008.05.043","volume":"16","author":"Shimizu M.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref28\/cit28b","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1021\/bi036056y","volume":"43","author":"Vanhooke J. L.","year":"2004","journal-title":"Biochemistry"},{"key":"ref28\/cit28c","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1097-2765(00)80413-X","volume":"5","author":"Rochel N.","year":"2000","journal-title":"Mol. Cell"},{"key":"ref28\/cit28d","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jsbmb.2006.12.003","volume":"103","author":"Ciesielski F.","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref28\/cit28e","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1073\/pnas.091018698","volume":"98","author":"Tocchini-Valentini G.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref28\/cit28f","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.chembiol.2008.08.008","volume":"15","author":"Eelen G.","year":"2008","journal-title":"Chem. Biol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/er.2003-0023","volume":"25","author":"Smith C. L.","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"36091","DOI":"10.1074\/jbc.M304153200","volume":"278","author":"Kaneko E.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0003-2697(90)90572-Q","volume":"186","author":"Tavangar K.","year":"1990","journal-title":"Anal. Biochem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"issue":"5","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Brunger A. T.","year":"1998","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"issue":"2","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/jsbi.1999.4094","volume":"125","author":"McRee D. E.","year":"1999","journal-title":"J. Struct. Biol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm401989c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T12:03:39Z","timestamp":1682165019000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm401989c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,7]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,5,22]]}},"alternative-id":["10.1021\/jm401989c"],"URL":"https:\/\/doi.org\/10.1021\/jm401989c","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,7]]}}}