{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:40:21Z","timestamp":1791333621862,"version":"4.3.1"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A series of N2,N4-disubstituted quinazoline-2,4-diamines has been synthesized and tested against Leishmania donovani and L. amazonensis intracellular amastigotes. A structure\u2013activity and structure\u2013property relationship study was conducted in part using the Topliss operational scheme to identify new lead compounds. This study led to the identification of quinazolines with EC50 values in the single digit micromolar or high nanomolar range in addition to favorable physicochemical properties. Quinazoline 23 also displayed efficacy in a murine model of visceral leishmaniasis, reducing liver parasitemia by 37% when given by the intraperitoneal route at 15 mg kg\u20131 day\u20131 for 5 consecutive days. Their antileishmanial efficacy, ease of synthesis, and favorable physicochemical properties make the N2,N4-disubstituted quinazoline-2,4-diamine compound series a suitable platform for future development of antileishmanial agents.<\/jats:p>","DOI":"10.1021\/jm5000408","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T16:08:18Z","timestamp":1401379698000},"page":"5141-5156","source":"Crossref","is-referenced-by-count":77,"title":["Antileishmanial Activity of a Series of\n                    <i>N<\/i>\n                    2,\n                    <i>N<\/i>\n                    4-Disubstituted\nQuinazoline-2,4-diamines"],"prefix":"10.1021","volume":"57","author":[{"given":"Kurt S.","family":"Van Horn","sequence":"first","affiliation":[{"name":"University of South Florida , , 4202 East Fowler Avenue, CHE 205 , , ,","place":["Tampa, Florida, United States, 33620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Ohio State University , , , ,","place":["Columbus, Ohio, United States, 43210"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti","family":"Pandharkar","sequence":"additional","affiliation":[{"name":"The Ohio State University , , , ,","place":["Columbus, Ohio, United States, 43210"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihyung","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Kansas , , , ,","place":["Lawrence, Kansas, United States, 66047"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Vesely","sequence":"additional","affiliation":[{"name":"University of South Florida , , , ,","place":["Tampa, Florida, United States, 33620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Vanaerschot","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine , , , ,","place":["Antwerp, Belgium, 2000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Dujardin","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine , , , ,","place":["Antwerp, Belgium, 2000"]},{"name":"University of Antwerp , , , ,","place":["Antwerp, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Rijal","sequence":"additional","affiliation":[{"name":"B. P. Koirala Institute of Health Sciences , , ,","place":["Ghopa, Dharan, Nepal, 56700"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Kyle","sequence":"additional","affiliation":[{"name":"University of South Florida , , , ,","place":["Tampa, Florida, United States, 33620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Zhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Kansas , , , ,","place":["Lawrence, Kansas, United States, 66047"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A.","family":"Werbovetz","sequence":"additional","affiliation":[{"name":"The Ohio State University , , , ,","place":["Columbus, Ohio, United States, 43210"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Manetsch","sequence":"additional","affiliation":[{"name":"University of South Florida , , 4202 East Fowler Avenue, CHE 205 , , ,","place":["Tampa, Florida, United States, 33620"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"key":"2026090313582440600_cit1","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro1748z","article-title":"Visceral leishmaniasis:\nWhat are the needs for diagnosis, treatment and control?","volume":"5","author":"Chappuis","year":"2007","journal-title":"Nat. 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