{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:25:46Z","timestamp":1778639146779,"version":"3.51.4"},"reference-count":12,"publisher":"American Chemical Society (ACS)","issue":"21","funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001338","name":"University of Capetown","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001342","name":"Department of Science and Technology, Republic of South Africa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004167","name":"Medicines for Malaria Venture","doi-asserted-by":"publisher","award":["MMV09\/0002"],"award-info":[{"award-number":["MMV09\/0002"]}],"id":[{"id":"10.13039\/501100004167","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2014,11,13]]},"DOI":"10.1021\/jm500887k","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T14:30:39Z","timestamp":1413297039000},"page":"8839-8848","source":"Crossref","is-referenced-by-count":33,"title":["Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 2"],"prefix":"10.1021","volume":"57","author":[{"given":"Claire","family":"Le Manach","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"},{"name":"South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Paquet","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Gonz\u00e0lez Cabrera","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassir","family":"Younis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubbe","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylva","family":"Schwager","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Waterson","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture, ICC, Route de Pr\u00e9-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Witty","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture, ICC, Route de Pr\u00e9-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Wittlin","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland"},{"name":"University of Basel, 4003 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie J.","family":"Street","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Chibale","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"},{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa"},{"name":"South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2014,10,23]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health Organization (WHO). World Malaria Report 2013.http:\/\/www.who.int\/malaria\/publications\/world_malaria_report_2013\/report\/en\/(accessed June 12, 2014) ."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.2174\/156802611795429194","volume":"11","author":"Burrows N. J.","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"Dondorp A. M.","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd1824","volume":"4","author":"Pink R.","year":"2005","journal-title":"Nat. Rev. Drug Dicovery"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1021\/jm500098s","volume":"57","author":"Le Manach C.","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1021\/cr00039a007","volume":"95","author":"Miyaura N.","year":"1995","journal-title":"Chem. Rev."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1021\/jo0402226","volume":"70","author":"Thompson A. E.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.vascn.2006.02.003","volume":"54","author":"Bridglang-Taylor M. H.","year":"2006","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref8\/cit8b","unstructured":"bEssen BioScience. Ion Channel Discovery Services (hERG IC50IonWorks Assay Example Report).http:\/\/www.essenbioscience.com\/media\/uploads\/files\/hERG_10xcpd_Exemplar_Report.pdf(accessed April 25, 2014) ."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0090-9556(24)14938-0","volume":"27","author":"Obach R. S.","year":"1999","journal-title":"Drug. Metab. Dispos."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.exppara.2006.09.016","volume":"115","author":"Snyder C.","year":"2007","journal-title":"Exp. Parasitol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"11022","DOI":"10.1021\/jm301476b","volume":"55","author":"Gonz\u00e1lez Cabrera D.","year":"2012","journal-title":"J. Med. Chem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm500887k","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:11:57Z","timestamp":1746418317000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm500887k"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,23]]},"references-count":12,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2014,11,13]]}},"alternative-id":["10.1021\/jm500887k"],"URL":"https:\/\/doi.org\/10.1021\/jm500887k","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,23]]}}}