{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:51:22Z","timestamp":1791165082403,"version":"4.1.0"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2015,2,12]]},"DOI":"10.1021\/jm501350y","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T09:55:58Z","timestamp":1422006958000},"page":"1159-1183","source":"Crossref","is-referenced-by-count":62,"title":["Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington\u2019s Disease"],"prefix":"10.1021","volume":"58","author":[{"given":"Leticia M.","family":"Toledo-Sherman","sequence":"first","affiliation":[{"name":"CHDI Management\/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, California 90405, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Prime","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Mrzljak","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation, 155 Village Boulevard, Suite 200, Princeton, New Jersey 08540, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Beconi","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, California 90405, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Beresford","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Chesterford Research Park, Saffron Walden, Essex, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Brookfield","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Cardaun","sequence":"additional","affiliation":[{"name":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Courtney","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Dijkman","sequence":"additional","affiliation":[{"name":"Brains On-Line LLC, 7000 Shoreline Court, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Hamelin-Flegg","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Kempf","sequence":"additional","affiliation":[{"name":"Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Lyons","sequence":"additional","affiliation":[{"name":"Kathryn A. Lyons, P.O. Box 64, Holland, New York 14080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Matthews","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Chesterford Research Park, Saffron Walden, Essex, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Chesterford Research Park, Saffron Walden, Essex, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Pena","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Powell","sequence":"additional","affiliation":[{"name":"Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Rassoulpour","sequence":"additional","affiliation":[{"name":"Brains On-Line LLC, 7000 Shoreline Court, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Reed","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Reindl","sequence":"additional","affiliation":[{"name":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suganathan","family":"Selvaratnam","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weslyn Ward","family":"Friley","sequence":"additional","affiliation":[{"name":"Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A.","family":"Weddell","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi E.","family":"Went","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Wheelan","sequence":"additional","affiliation":[{"name":"Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Winkler","sequence":"additional","affiliation":[{"name":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Winkler","sequence":"additional","affiliation":[{"name":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wityak","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, California 90405, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Yarnold","sequence":"additional","affiliation":[{"name":"Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Yates","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Chesterford Research Park, Saffron Walden, Essex, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Munoz-Sanjuan","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, California 90405, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Dominguez","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, California 90405, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,1,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/B978-0-12-381328-2.00014-6","volume":"98","author":"Reiner A.","year":"2011","journal-title":"Int. Rev. Neurobiol."},{"issue":"9","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/hbm.22055","volume":"34","author":"Delmaire C.","year":"2013","journal-title":"Hum. Brain Mapping"},{"issue":"6","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1345\/aph.1M582","volume":"44","author":"Poon L. H.","year":"2010","journal-title":"Ann. Pharmacother."},{"issue":"7","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","volume":"13","author":"Schwarcz R.","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nrd3793","volume":"12","author":"V\u00e9csei L.","year":"2013","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"2","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00702-011-0681-y","volume":"119","author":"Mandi Y.","year":"2012","journal-title":"J. Neural. Transm."},{"issue":"1","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","volume":"32","author":"Belenky P.","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/IJTR.S2097","volume":"2","author":"Chen Y.","year":"2009","journal-title":"Int. J. Tryptophan Res."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.pneurobio.2009.04.005","volume":"90","author":"Schwarcz R.","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nbd.2004.07.006","volume":"17","author":"Guidetti P.","year":"2004","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2006.02.011","volume":"23","author":"Guidetti P.","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1471-4159.2009.06442.x","volume":"112","author":"Forrest C. M.","year":"2010","journal-title":"J. Neurochem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2174\/187152710793237430","volume":"9","author":"Thevandavakkam M. A.","year":"2010","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"issue":"5","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ng1542","volume":"37","author":"Giorgini F.","year":"2005","journal-title":"Nat. Genet."},{"issue":"11","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cub.2011.04.028","volume":"21","author":"Campesan S.","year":"2011","journal-title":"Curr. Biol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/978-1-4615-0135-0_71","volume":"527","author":"Pellicciari R.","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1471-4159.2009.05893.x","volume":"109","author":"Amori L.","year":"2009","journal-title":"J. Neurochem."},{"issue":"2","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj3260351","volume":"326","author":"Heyes M. P.","year":"1997","journal-title":"Biochem. J."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4615-0135-0_12","volume":"527","author":"Guillemin G. J.","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jnr.20505","volume":"80","author":"Rzeski W.","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.034439","volume":"303","author":"Schwarcz R.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"12884","DOI":"10.1523\/JNEUROSCI.4101-07.2007","volume":"27","author":"Guillemin G. J.","year":"2007","journal-title":"J. Neurosci."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","volume":"13","author":"Schwarcz R.","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/j.1471-4159.1991.tb03460.x","volume":"56","author":"Fukui S.","year":"1991","journal-title":"J. Neurochem."},{"issue":"6","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","volume":"145","author":"Zwilling D.","year":"2011","journal-title":"Cell."},{"issue":"2","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1046\/j.1471-4159.1996.67020692.x","volume":"67","author":"Chiarugi A.","year":"1996","journal-title":"J. Neurochem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0306-4522(92)90467-G","volume":"51","author":"Saito K.","year":"1992","journal-title":"Neuroscience"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuropharm.2013.02.006","volume":"70","author":"Klein C.","year":"2013","journal-title":"Neuropharmacology"},{"issue":"4","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-6147(00)01451-6","volume":"21","author":"Stone T. W.","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"issue":"8","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrd870","volume":"1","author":"Stone T. W.","year":"2002","journal-title":"Nat. Rev. Drug. Discovery"},{"issue":"10","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1097\/00001756-199406020-00026","volume":"5","author":"Storey E.","year":"1994","journal-title":"Neuroreport."},{"issue":"4582","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.6849138","volume":"219","author":"Schwarcz R.","year":"1983","journal-title":"Science"},{"issue":"6","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1523\/JNEUROSCI.11-06-01649.1991","volume":"11","author":"Beal M. F.","year":"1991","journal-title":"J. Neurosci."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"12553","DOI":"10.1073\/pnas.93.22.12553","volume":"93","author":"Okuda S.","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1515\/CCLM.2003.129","volume":"41","author":"Stone T. W.","year":"2003","journal-title":"Clin. Chem. Lab. Med."},{"issue":"6","key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/1756285613494989","volume":"6","author":"Majl\u00e1th Z.","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0022-3565(24)37160-5","volume":"283","author":"Parsons C. G.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.expneurol.2005.07.004","volume":"197","author":"Sapko M. T.","year":"2006","journal-title":"Exp. Neurol."},{"issue":"1","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neuroscience.2007.05.033","volume":"148","author":"Poeggeler B.","year":"2007","journal-title":"Neuroscience"},{"issue":"2","key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1046\/j.1471-4159.1996.67020692.x","volume":"67","author":"Chiarugi A.","year":"1996","journal-title":"J. Neurochem."},{"issue":"3","key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-2999(96)00613-9","volume":"315","author":"Speciale C.","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.expneurol.2005.07.004","volume":"197","author":"Sapko M. T.","year":"2006","journal-title":"Exp. Neurol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1021\/jm970467t","volume":"40","author":"R\u00f6ver S.","year":"1997","journal-title":"J. Med. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4615-4709-9_26","volume":"467","author":"Moroni F.","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00004647-199907000-00007","volume":"19","author":"Cozzi A.","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"7","key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/mds.20596","volume":"20","author":"Samadi P.","year":"2005","journal-title":"Mov. Disord."},{"issue":"12","key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1124\/dmd.112.046532","volume":"40","author":"Beconi M. G.","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"ref48\/cit48","unstructured":"Courtney, S. M.; Prime, M.; Mitchell, W.; Brown, C. J.; De Aguiar Pena, P. C.; Johnson, P.; Dominguez, C.; Toledo-Sherman, L. M.; Munoz, I.Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions and Methods of use Thereof. International Patent WO2013\/033085, Mar 7, 2013."},{"key":"ref49\/cit49","unstructured":"Dominguez, C.; Toledo-Sherman, L. M.; Courtney, S. M.; Prime, M.; Mitchell, W.; Brown, C. J.; De Aguiar Pena, P. C.; Johnson, P.Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions and Methods of use Thereof. International Patent WO2013\/016488, Jan 31, 2013."},{"issue":"7","key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1021\/cr00039a007","volume":"95","author":"Miyaura N.","year":"1995","journal-title":"Chem. Rev."},{"issue":"13","key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/ol0498287","volume":"6","author":"Albaneze-Walker J.","year":"2004","journal-title":"Org. Lett."},{"issue":"25","key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1016\/j.tet.2007.04.063","volume":"63","author":"van der Westhuyzen C. W.","year":"2007","journal-title":"Tetrahedron"},{"issue":"1","key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/ja00313a032","volume":"106","author":"Hayashi T.","year":"1984","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1021\/ja00886a029","volume":"85","author":"Pearson R. E.","year":"1963","journal-title":"J. Am. Chem. Soc."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-1989-27225","volume":"4","author":"Bernard A. M.","year":"1989","journal-title":"Synthesis"},{"issue":"5","key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3987\/COM-07-11014","volume":"71","author":"Dol\u00e1kov\u00e1 P.","year":"2007","journal-title":"Heterocycles"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1021\/ja01548a028","volume":"80","author":"Finnegan W. G.","year":"1958","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bmcl.2008.11.040","volume":"19","author":"Charton J.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6","key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/jhet.5570160621","volume":"16","author":"Santilli A.","year":"1979","journal-title":"J. Heterocycl. Chem."},{"issue":"10","key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0960-894X(03)00244-0","volume":"13","author":"Manley P. J.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"8","key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/1087057113489731","volume":"18","author":"Winkler D.","year":"2013","journal-title":"J. Biol. Screening."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.pharmthera.2005.01.001","volume":"106","author":"Krueger S. K.","year":"2005","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0166-1280(98)00396-0","volume":"463","author":"Melo A.","year":"1999","journal-title":"J. Mol. Struct.: THEOCHEM"},{"issue":"7445","key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature12039","volume":"496","author":"Amaral M.","year":"2013","journal-title":"Nature"},{"issue":"4","key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1517\/17425255.2012.668184","volume":"8","author":"Krajcsi P.","year":"2012","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"5","key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0028-3908(93)90171-X","volume":"32","author":"Jauch D. A.","year":"1993","journal-title":"Neuropharmacology"},{"issue":"3","key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00213-011-2539-2","volume":"220","author":"Alexander K. S.","year":"2012","journal-title":"Psychopharmacology"},{"key":"ref68\/cit68","volume-title":"Handbook of Microdialyis \u2013 Methods, Applications and Clinical Aspects","author":"Westerink B. H. C.","year":"2007"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm501350y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T10:32:44Z","timestamp":1747477964000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm501350y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,23]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2,12]]}},"alternative-id":["10.1021\/jm501350y"],"URL":"https:\/\/doi.org\/10.1021\/jm501350y","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,23]]}}}