{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:40:39Z","timestamp":1791639639471,"version":"4.3.4"},"reference-count":134,"publisher":"American Chemical Society (ACS)","issue":"17","funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit? di Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2015,9,10]]},"DOI":"10.1021\/jm501690r","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T16:39:52Z","timestamp":1430152792000},"page":"6717-6732","source":"Crossref","is-referenced-by-count":213,"title":["New Frontiers in Selective Human MAO-B Inhibitors"],"prefix":"10.1021","volume":"58","author":[{"given":"Simone","family":"Carradori","sequence":"first","affiliation":[{"name":"Dipartimento Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza Universit\u00e0 di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Dipartimento Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza Universit\u00e0 di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,5,11]]},"reference":[{"key":"ref1\/cit1","volume-title":"Structure and Function of Amine Oxidases","author":"Mondov\u00ec B.","year":"1985"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/jcbfm.2013.19","volume":"33","author":"Tong J.","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref3\/cit3","first-page":"1255","volume":"36","author":"Fowler J. S.","year":"1995","journal-title":"J. Nucl. Med."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1073\/pnas.85.13.4934","volume":"85","author":"Bach A. W. J.","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0079-6603(00)65004-3","volume":"65","author":"Abell C. W.","year":"2001","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.2174\/0929867043364810","volume":"11","author":"Tipton K. F.","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"24S","DOI":"10.1016\/0002-9343(94)90360-3","volume":"97","author":"Andrews J. M.","year":"1994","journal-title":"Am. J. Med. Chem."},{"key":"ref8\/cit8","first-page":"171","volume":"38","author":"Cesura A. M.","year":"2002","journal-title":"Prog. Drug Res."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrn1883","volume":"7","author":"Youdim M. B.","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-2952(99)00340-8","volume":"59","author":"Drukarch B.","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/npp.2014.214","volume":"40","author":"Fowler J. S.","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1517\/13543776.2014.982535","volume":"25","author":"Carradori S.","year":"2015","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/2045125311413497","volume":"1","author":"Yates S. J.","year":"2011","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref14\/cit14","first-page":"CD006661","volume":"7","author":"Caslake R.","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.parkreldis.2013.06.001","volume":"19","author":"Elmer L. W.","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2014.00180","volume":"6","author":"Krishna R.","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/jama.2014.3654","volume":"311","author":"Connolly B. S.","year":"2014","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-0447.1987.tb02881.x","volume":"76","author":"Schalling D.","year":"1987","journal-title":"Acta Psychiatr. Scand."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1471-4159.1993.tb03554.x","volume":"61","author":"Chen K.","year":"1993","journal-title":"J. Neurochem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neulet.2011.06.026","volume":"500","author":"Sviglin K. N.","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/alcalc\/agm031","volume":"42","author":"Berggren U.","year":"2007","journal-title":"Alcohol Alcohol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000275820","volume":"61","author":"Gustavson C.","year":"2010","journal-title":"Neuropsychobiology"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.eurpsy.2007.06.006","volume":"22","author":"Arrojo M.","year":"2007","journal-title":"Eur. Psychiatry"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu151"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s11064-009-9929-4","volume":"34","author":"Husain M.","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref26\/cit26","first-page":"112","volume":"6","author":"Duncan J.","year":"2012","journal-title":"Drug Discovery Ther."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pnpbp.2014.07.002","volume":"54","author":"Erjavec G. N.","year":"2014","journal-title":"Progr. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/acer.12229","volume":"38","author":"Udemgba C.","year":"2014","journal-title":"Alcohol.: Clin. Exp. Res."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.1073\/pnas.1633804100","volume":"100","author":"Binda C.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1021\/jm801590u","volume":"52","author":"Chimenti F.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1016\/j.bmcl.2013.06.050","volume":"23","author":"Robinson S. J.","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1212\/WNL.67.7_suppl_2.S5","volume":"67","author":"Binda C.","year":"2006","journal-title":"Neurology"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejmech.2012.11.006","volume":"59","author":"Desideri N.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1016\/j.bmcl.2005.07.043","volume":"15","author":"Toprak\u00e7\u00ed M.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1016\/j.ejmech.2011.08.036","volume":"46","author":"Legoabe L.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.2174\/092986711797636090","volume":"18","author":"Secci D.","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.2174\/156802612805220057","volume":"12","author":"Secci D.","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.bmcl.2011.02.030","volume":"21","author":"Mishra N.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1016\/j.bmcl.2013.07.035","volume":"23","author":"Fioravanti R.","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1016\/j.bmcl.2010.09.061","volume":"20","author":"Fioravanti R.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ejmech.2009.11.003","volume":"45","author":"Chimenti F.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1016\/j.ejmech.2010.07.009","volume":"45","author":"Maccioni E.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.1021\/jm2002876","volume":"54","author":"Maccioni E.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1016\/j.bmcl.2010.03.081","volume":"20","author":"Alcaro S.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bmcl.2010.11.128","volume":"21","author":"Gaspar J. Reis","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1021\/jm2004267","volume":"54","author":"Gaspar A.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/cmdc.201000452","volume":"6","author":"Gaspar A.","year":"2011","journal-title":"ChemMedChem"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ejmech.2012.01.037","volume":"49","author":"Legoabe L. J.","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1021\/jm070677y","volume":"50","author":"Binda C.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bmc.2009.12.029","volume":"18","author":"Chimenti F.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1021\/jm1013709","volume":"54","author":"Desideri N.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.bmcl.2011.12.056","volume":"22","author":"Geldenhuys W. J.","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1016\/j.bmc.2011.10.049","volume":"19","author":"Cerqueira E. C.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/cbdd.12255","volume":"83","author":"Cerqueira E. C.","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1006\/bbrc.1994.2111","volume":"202","author":"Woo J. C.","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bmcl.2005.10.013","volume":"16","author":"Vilar S.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1016\/j.bmcl.2009.04.085","volume":"19","author":"Matos M. J.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1016\/j.bmcl.2009.07.039","volume":"19","author":"Matos M. J.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1016\/j.bmcl.2010.07.013","volume":"20","author":"Matos M. J.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1021\/jm200716y","volume":"54","author":"Matos M. J.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/cmdc.201300048","volume":"8","author":"Ferino G.","year":"2013","journal-title":"ChemMedChem"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/cmdc.201402010","volume":"8","author":"Delogu G. L.","year":"2014","journal-title":"ChemMedChem"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bmcl.2011.11.020","volume":"22","author":"Serra S.","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1016\/j.bmcl.2011.05.074","volume":"21","author":"Matos M. J.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1016\/j.ejmech.2011.07.017","volume":"46","author":"Secci D.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.ejmech.2011.01.033","volume":"46","author":"Delogu G.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1021\/jm801496u","volume":"52","author":"Chimenti F.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1021\/jm800656v","volume":"51","author":"Santana L.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1039\/C1MD00221J","volume":"3","author":"Vi\u00f1a D.","year":"2012","journal-title":"MedChemComm"},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejmech.2013.02.009","volume":"63","author":"Matos M. J.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1021\/jm9010127","volume":"52","author":"Pisani L.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/cmdc.201300048","volume":"8","author":"Ferino G.","year":"2013","journal-title":"ChemMedChem"},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1016\/j.ejmech.2010.07.005","volume":"45","author":"Prins L. H. A.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1016\/j.bmcl.2013.08.071","volume":"23","author":"Meiring L.","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainres.2007.11.051","volume":"1191","author":"Aguiar L. M. V.","year":"2008","journal-title":"Brain Res."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"8676","DOI":"10.1016\/j.bmc.2008.07.088","volume":"16","author":"Pretorius J.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/j.bmc.2006.01.011","volume":"14","author":"Vlok V.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.bmc.2009.12.064","volume":"18","author":"Strydom B.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1016\/j.ejmech.2011.05.014","volume":"46","author":"Strydom B.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1016\/j.bmc.2011.10.036","volume":"19","author":"Booysen H. P.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1016\/j.bmc.2012.10.005","volume":"20","author":"Mostert S.","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.bmc.2012.05.048","volume":"20","author":"Okaecwe T.","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/jphp.12193","volume":"66","author":"Petzer A.","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1021\/jm301686s","volume":"56","author":"Rivara S.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1016\/j.bmc.2013.09.044","volume":"21","author":"Koch P.","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.bmcl.2009.03.030","volume":"19","author":"Van der Walt E. M.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bmc.2010.11.028","volume":"19","author":"Manley-King C. I.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1016\/j.bmc.2011.06.070","volume":"19","author":"Manley-King C. I.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bmcl.2013.01.003","volume":"23","author":"Strydom B.","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bmc.2010.11.028","volume":"19","author":"Manley-King C. I.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1016\/j.bmcl.2010.06.128","volume":"20","author":"Geldenhuys W. J.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1021\/ml200196p","volume":"3","author":"Binda C.","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1016\/j.bmcl.2010.06.128","volume":"20","author":"Geldenhuys W. J.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1016\/j.bmcl.2011.06.060","volume":"21","author":"Carroll R. T.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.bmcl.2011.12.056","volume":"22","author":"Geldenhuys W. J.","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref96\/cit96","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.brainres.2006.09.003","volume":"1122","author":"Wood P.","year":"2006","journal-title":"Brain Res."},{"issue":"202","key":"ref97\/cit97","volume":"73","author":"Todd K. G.","year":"1999","journal-title":"J. Neurochem."},{"key":"ref98\/cit98","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1016\/j.bmc.2010.06.007","volume":"18","author":"Chimenti F.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref99\/cit99","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1039\/c0md00014k","volume":"1","author":"Chimenti F.","year":"2010","journal-title":"MedChemComm"},{"key":"ref100\/cit100","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1021\/jm800132g","volume":"51","author":"Chimenti F.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jhet.110","volume":"46","author":"Chimenti F.","year":"2009","journal-title":"J. Heterocycl. Chem."},{"key":"ref102\/cit102","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1016\/j.bmc.2010.05.070","volume":"18","author":"Chimenti F.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref103\/cit103","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.bmc.2014.03.042","volume":"22","author":"D\u2019Ascenzio M.","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"ref104\/cit104","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1021\/jm100120s","volume":"53","author":"Chimenti F.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref105\/cit105","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejmech.2011.12.027","volume":"48","author":"Distinto S.","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref106\/cit106","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ejmech.2012.10.032","volume":"58","author":"Secci D.","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref107\/cit107","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ardp.201200318","volume":"346","author":"Carradori S.","year":"2013","journal-title":"Arch. Pharm."},{"key":"ref108\/cit108","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejmech.2013.05.032","volume":"66","author":"Chimenti P.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref109\/cit109","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1021\/bi9002106","volume":"48","author":"Upadhyay A. K.","year":"2009","journal-title":"Biochemistry"},{"key":"ref110\/cit110","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1021\/bi7019707","volume":"47","author":"Upadhyay A. K.","year":"2008","journal-title":"Biochemistry"},{"key":"ref111\/cit111","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1016\/j.bmc.2008.06.048","volume":"16","author":"Hruschka S.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref112\/cit112","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ejmech.2013.01.039","volume":"62","author":"Lu C.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref113\/cit113","doi-asserted-by":"crossref","first-page":"7406","DOI":"10.1016\/j.bmc.2013.09.050","volume":"21","author":"Sun Y.","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref114\/cit114","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00726-011-1006-z","volume":"42","author":"Bonaiuto E.","year":"2012","journal-title":"Amino Acids"},{"key":"ref115\/cit115","first-page":"7088","volume":"48","author":"Bonaiuto E.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref116\/cit116","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1016\/j.ejmech.2011.05.048","volume":"46","author":"Samadi A.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref117\/cit117","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/jm201692d","volume":"55","author":"Pettersson F.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.bmc.2010.01.029","volume":"18","author":"L\u00fchr S.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref119\/cit119","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1039\/c1md00176k","volume":"2","author":"Geldenhuys W. J.","year":"2011","journal-title":"MedChemComm"},{"key":"ref120\/cit120","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1021\/jm991164x","volume":"43","author":"Mor\u00f3n J. A.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref121\/cit121","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1016\/j.ejmech.2010.07.005","volume":"45","author":"Prins L. H. A.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref122\/cit122","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1021\/jm400336x","volume":"56","author":"St\u00f6\u00dfel A.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref123\/cit123","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.1073\/pnas.1633804100","volume":"100","author":"Binda C.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref124\/cit124","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1021\/jm070677y","volume":"50","author":"Binda C.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref125\/cit125","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11030-013-9490-6","volume":"18","author":"Carradori S.","year":"2014","journal-title":"Mol. Diversity"},{"key":"ref126\/cit126","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1021\/jm060441e","volume":"49","author":"Novaroli L.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref127\/cit127","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1517\/13543776.15.12.1763","volume":"15","author":"Bolasco A.","year":"2005","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref128\/cit128","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/13543776.2010.495716","volume":"20","author":"Bolasco A.","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref129\/cit129","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1517\/13543776.2012.698613","volume":"22","author":"Carradori S.","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref130\/cit130","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.phrs.2010.09.001","volume":"62","author":"McDonald G. R.","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref131\/cit131","doi-asserted-by":"crossref","first-page":"36849","DOI":"10.1074\/jbc.M110.169482","volume":"285","author":"Bonivento D.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref132\/cit132","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/ci400346k","volume":"54","author":"Basile L.","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"ref133\/cit133","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/med.21269","volume":"33","author":"Khan M. N.","year":"2013","journal-title":"Med. Res. Rev."},{"key":"ref134\/cit134","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2174\/1389202914666131210210241","volume":"14","author":"Dorsezewska J.","year":"2013","journal-title":"Curr. Genomics"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm501690r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T16:05:44Z","timestamp":1748361944000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm501690r"}},"subtitle":["Miniperspective"],"short-title":[],"issued":{"date-parts":[[2015,5,11]]},"references-count":134,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2015,9,10]]}},"alternative-id":["10.1021\/jm501690r"],"URL":"https:\/\/doi.org\/10.1021\/jm501690r","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,11]]}}}