{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:33:28Z","timestamp":1777566808330,"version":"3.51.4"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"5","funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["MOST 101-2325-B-400-016"],"award-info":[{"award-number":["MOST 101-2325-B-400-016"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2015,3,12]]},"DOI":"10.1021\/jm501769r","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T20:29:19Z","timestamp":1424118559000},"page":"2315-2325","source":"Crossref","is-referenced-by-count":21,"title":["Stem Cell Mobilizers Targeting Chemokine Receptor CXCR4: Renoprotective Application in Acute Kidney Injury"],"prefix":"10.1021","volume":"58","author":[{"given":"Chien-Huang","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Shin","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuei-Hua","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiing-Jyh","family":"Jan","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung-Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chen","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Chia","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Chieh","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Tso","family":"Tseng","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Huei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Fang","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Hsien","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit A.","family":"Sadani","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ping","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun K.","family":"Tsou","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kak-Shan","family":"Shia","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology\rand Pharmaceutical Research, National Health Research Institutes, Miaoli, Miaoli County 35053, Taiwan R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1136\/bmj.38975.657639.AE","volume":"333","author":"Hilton R.","year":"2006","journal-title":"BMJ (Br. Med. J.)"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2215\/CJN.05191107","volume":"3","author":"Waikar S. S.","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref3\/cit3","first-page":"F1064","volume":"305","author":"Liu N.","year":"2013","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/jcb.24615","volume":"114","author":"Liu N.","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/scrt212","volume":"4","author":"Chen Y. T.","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.transproceed.2013.01.096","volume":"45","author":"Chen B.","year":"2013","journal-title":"Transplant. Proc."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.med.59.061506.154239","volume":"59","author":"Humphreys B. D.","year":"2008","journal-title":"Annu. Rev. Med."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1797.2011.01501.x","volume":"17","author":"Wise A. F.","year":"2012","journal-title":"Nephrology"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1093\/emboj\/16.23.6996","volume":"16","author":"Crump M. P.","year":"1997","journal-title":"EMBO J."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.molmed.2013.12.002","volume":"20","author":"Anders H. J.","year":"2014","journal-title":"Trends Mol. Med."},{"key":"ref11\/cit11","first-page":"5930","volume":"62","author":"Scotton C. J.","year":"2002","journal-title":"Cancer Res."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.semcancer.2003.10.003","volume":"14","author":"Balkwill F.","year":"2004","journal-title":"Semin. Cancer Biol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1210\/jc.2002-021381","volume":"88","author":"Hwang J. H.","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1158\/1541-7786.MCR-04-0193","volume":"3","author":"Peng S. B.","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2172-9-51","volume":"9","author":"Leng Q.","year":"2008","journal-title":"BMC Immunol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1749-6632.1995.tb31044.x","volume":"770","author":"Clark B. R.","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref17\/cit17","first-page":"13","volume":"109","author":"Lattanzio M. R.","year":"2009","journal-title":"J. Am. Osteopath. Assoc."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.bcp.2008.12.014","volume":"77","author":"De Clercq E.","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1182\/blood-2003-02-0663","volume":"102","author":"Liles W. C.","year":"2003","journal-title":"Blood"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1200\/JCO.2004.07.131","volume":"22","author":"Devine S. M.","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3816\/SCT.2004.n.008","volume":"1","author":"H\u00fcbel K.","year":"2004","journal-title":"Support. Cancer Ther."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3816\/CLM.2007.n.009","volume":"7","author":"Holtan S. G.","year":"2007","journal-title":"Clin. Lymphoma Myeloma"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.bbmt.2008.08.011","volume":"14","author":"Cashen A.","year":"2008","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000315736","volume":"78","author":"Brave M.","year":"2010","journal-title":"Oncology"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrd2819","volume":"8","author":"DiPersio J. F.","year":"2009","journal-title":"Nature Rev. Drug Discovery"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.bmt.1705908","volume":"41","author":"Calandra G.","year":"2008","journal-title":"Biol. Bone Marrow Transplant."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1182\/blood-2006-06-030577","volume":"108","author":"Shepherd R. M.","year":"2006","journal-title":"Blood"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.3748\/wjg.v16.i23.2873","volume":"16","author":"Xia X. M.","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"e50105","DOI":"10.1371\/journal.pone.0050105","volume":"7","author":"Chen J.","year":"2012","journal-title":"PloS One"},{"key":"ref30\/cit30a","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1021\/cb4008277","volume":"9","author":"L\u00e4ngle D.","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"ref30\/cit30b","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7150\/thno.5376","volume":"3","author":"Debnath B.","year":"2013","journal-title":"Theranostics"},{"key":"ref30\/cit30c","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1021\/jm200568c","volume":"55","author":"Choi W. T.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref30\/cit30d","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1039\/c0md00055h","volume":"1","author":"Allsopp T. E.","year":"2010","journal-title":"Med. Chem. Commun."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1006\/bbrc.1998.9871","volume":"253","author":"Tamamura H.","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref32\/cit32a","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X681739"},{"key":"ref32\/cit32b","first-page":"866","volume":"114","author":"Chung D. T.","year":"2009","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"ref32\/cit32c","first-page":"3542","volume":"114","author":"Huang Y. H.","year":"2009","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"ref32\/cit32d","unstructured":"dYen, C. F.; Hu, C. K.; Chou, M. C.; Tseng, C. T.; Wu, C. H.; Huang, Y. H.; Chen, S. J.; King, C. H. R.Pyrimidine compounds. US7589197 B2, 2009."},{"key":"ref32\/cit32e","unstructured":"eYen, C. F.; Hu, C. K.; Huang, C. P.; Huang, Y. H.; Hakimelahi, G. H.; King, C. H. R.Heterocyclic compounds. US8372849 B2, 2013."},{"key":"ref32\/cit32f","unstructured":"fBurixafor. (http:\/\/pubchem.ncbi.nlm.nih.gov\/summary\/summary.cgi?cid=44479007, news released onDecember15, 2009) ."},{"key":"ref32\/cit32g","unstructured":"gPD and safety of TG-0054 combined with G-CSF in multiple myeloma, non-Hodgkin lymphoma and Hodgkin disease patients.ClinicalTrials.gov;U.S. National Institutes of Health:Bethesda, MD;http:\/\/clinicaltralsgov."},{"key":"ref33\/cit33a","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/AAC.00013-07","volume":"51","author":"Stone N. D.","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref33\/cit33b","unstructured":"bSafety and activity of the oral HIV entry inhibitor AMD11070 in HIV infected patients.U.S. National Institutes of Health:Bethesda, MD;http:\/\/clinicaltralsgov."},{"key":"ref34\/cit34a","doi-asserted-by":"crossref","first-page":"e79768","DOI":"10.1371\/journal.pone.0079768","volume":"8","author":"Shu H. K. G.","year":"2013","journal-title":"PloS One"},{"key":"ref34\/cit34b","unstructured":"bMSX-122 administered orally in patients with refractory metastatic or locally advanced solid tumors.U.S. National Institutes of Health:Bethesda, MD;http:\/\/clinicaltralsgov."},{"key":"ref35\/cit35a","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1158\/1535-7163.MCT-13-0410","volume":"13","author":"Beider K.","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"ref35\/cit35b","unstructured":"bImatinib and BL-8040 (novel anti CXCR4 antagonist) for improving molecular response in chronic myelogenous leukemia.U.S. National Institutes of Health:Bethesda, MD;http:\/\/clinicaltralsgov."},{"key":"ref36\/cit36a","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1158\/1078-0432.CCR-13-2686","volume":"20","author":"Galsky M. D.","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref36\/cit36b","unstructured":"bA study of LY2510924 in patients with extensive-stage small cell lung carcinoma (http:\/\/clinicaltralsgov)."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1158\/1078-0432.CCR-07-4846","volume":"14","author":"Wong D.","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref38\/cit38a","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.chembiol.2012.11.001","volume":"19","author":"Wolfson W.","year":"2012","journal-title":"Chem. Biol."},{"key":"ref38\/cit38b","first-page":"824","volume":"116","author":"Schmitt S.","year":"2010","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"ref38\/cit38c","first-page":"2179","volume":"116","author":"Chen Y.","year":"2010","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"ref38\/cit38d","unstructured":"dSafety and efficacy of POL6326 for mobilization\/transplant of sibling donor in patients with hematologic malignancies.U.S. National Institutes of Health:Bethesda, MD;http:\/\/clinicaltralsgov."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cmdc.201100525","volume":"7","author":"Wu C. H.","year":"2012","journal-title":"ChemMedChem"},{"key":"ref40\/cit40a","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1073\/pnas.0630420100","volume":"100","author":"Ichiyama K.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref40\/cit40b","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1021\/jm050009h","volume":"48","author":"Tamamura H.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref40\/cit40c","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1021\/jm0607350","volume":"50","author":"Ueda S.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref40\/cit40d","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1021\/ol800654n","volume":"10","author":"Demmer O.","year":"2008","journal-title":"Org. Lett."},{"key":"ref40\/cit40e","doi-asserted-by":"crossref","first-page":"7915","DOI":"10.1021\/jm801065q","volume":"51","author":"Thoma G.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref40\/cit40f","doi-asserted-by":"crossref","first-page":"8556","DOI":"10.1021\/jm100786g","volume":"53","author":"Zhu A.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref40\/cit40g","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1016\/j.bmcl.2010.03.118","volume":"20","author":"Miller J. F.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref40\/cit40h","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.bmcl.2010.02.030","volume":"20","author":"Catalano J. G.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref40\/cit40i","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.bmcl.2010.02.053","volume":"20","author":"Miller J. F.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref40\/cit40j","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bmcl.2010.11.023","volume":"21","author":"Skerlj R.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref40\/cit40k","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1039\/c0ob01193b","volume":"9","author":"Inokuchi E.","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"ref40\/cit40l","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/ml200047e","volume":"2","author":"Inokuchi E.","year":"2011","journal-title":"Med. Chem. Lett."},{"key":"ref40\/cit40m","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/cmdc.201200582","volume":"8","author":"Mooring S. R.","year":"2013","journal-title":"ChemMedChem"},{"key":"ref41\/cit41a","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.1194396","volume":"330","author":"Wu B.","year":"2010","journal-title":"Science"},{"key":"ref41\/cit41b","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.sbi.2013.05.003","volume":"23","author":"Zhu L.","year":"2013","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jvs.2008.08.077","volume":"49","author":"Westvik T. S.","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/stem.1369","volume":"31","author":"An N.","year":"2013","journal-title":"Stem Cells"},{"key":"ref44\/cit44","first-page":"F783","volume":"307","author":"Zuk A.","year":"2014","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-1960-0","volume-title":"Novel Developments in Stem Cell Mobilization Focus on CXCR4","author":"Fruehauf S.","year":"2012"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm501769r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:56:30Z","timestamp":1681520190000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm501769r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,2]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,3,12]]}},"alternative-id":["10.1021\/jm501769r"],"URL":"https:\/\/doi.org\/10.1021\/jm501769r","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,2]]}}}