{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:57:45Z","timestamp":1773727065081,"version":"3.50.1"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2015,2,12]]},"DOI":"10.1021\/jm501814x","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T11:39:47Z","timestamp":1421235587000},"page":"1502-1512","source":"Crossref","is-referenced-by-count":17,"title":["2-(2-Oxo-morpholin-3-yl)-acetamide Derivatives as Broad-Spectrum Antifungal Agents"],"prefix":"10.1021","volume":"58","author":[{"given":"Doroth\u00e9e","family":"Bardiot","sequence":"first","affiliation":[{"name":"Cistim Leuven vzw, Bioincubator\r2, Gaston Geenslaan 2, 3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Thevissen","sequence":"additional","affiliation":[{"name":"Centre\rof Microbial and Plant Genetics, CMPG, KU Leuven, Kasteelpark Arenberg\r20, Box 2460, 3001 Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrijn","family":"De Brucker","sequence":"additional","affiliation":[{"name":"Centre\rof Microbial and Plant Genetics, CMPG, KU Leuven, Kasteelpark Arenberg\r20, Box 2460, 3001 Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Peeters","sequence":"additional","affiliation":[{"name":"Centre\rof Microbial and Plant Genetics, CMPG, KU Leuven, Kasteelpark Arenberg\r20, Box 2460, 3001 Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cos","sequence":"additional","affiliation":[{"name":"Laboratory\rof Microbiology, Parasitology and Hygiene (LMPH), Universiteit Antwerpen, Campus Drie Eiken, building S, Universiteitsplein 1, 2610 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos P.","family":"Taborda","sequence":"additional","affiliation":[{"name":"Instituto\rde Ciencias Biomedicas, Departamento de Microbiologia, Universidade de Sao Paulo, Sao Paulo, SP 05508-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"McNaughton","sequence":"additional","affiliation":[{"name":"Cistim Leuven vzw, Bioincubator\r2, Gaston Geenslaan 2, 3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Maes","sequence":"additional","affiliation":[{"name":"Laboratory\rof Microbiology, Parasitology and Hygiene (LMPH), Universiteit Antwerpen, Campus Drie Eiken, building S, Universiteitsplein 1, 2610 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Chaltin","sequence":"additional","affiliation":[{"name":"Cistim Leuven vzw, Bioincubator\r2, Gaston Geenslaan 2, 3001 Leuven, Belgium"},{"name":"Centre for Drug Design and Discovery, Bioincubator 2, Gaston Geenslaan 2, 3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno P. A.","family":"Cammue","sequence":"additional","affiliation":[{"name":"Centre\rof Microbial and Plant Genetics, CMPG, KU Leuven, Kasteelpark Arenberg\r20, Box 2460, 3001 Heverlee, Belgium"},{"name":"Department\rof Plant Systems Biology, VIB, Technologiepark 927, 9052, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Marchand","sequence":"additional","affiliation":[{"name":"Cistim Leuven vzw, Bioincubator\r2, Gaston Geenslaan 2, 3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"e59373","DOI":"10.1371\/journal.pone.0059373","volume":"8","author":"Nucci M.","year":"2013","journal-title":"PLoS One"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00001432-200212000-00003","volume":"15","author":"Clark T. A.","year":"2002","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijantimicag.2006.01.002","volume":"27","author":"Tortorano A. M.","year":"2006","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref4\/cit4","first-page":"9","volume":"18","author":"Marr K. A.","year":"2004","journal-title":"Oncology"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1439-0507.2008.01642.x","volume":"52","author":"Krishnan S.","year":"2009","journal-title":"Mycoses"},{"key":"ref6\/cit6","first-page":"197","volume":"119","author":"Chapman S. W.","year":"2008","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1016\/j.bmc.2012.04.045","volume":"20","author":"Kathiravan M. K.","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrd3074","volume":"9","author":"Ostrosky-Zeichner L.","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"e25136","DOI":"10.1371\/journal.pone.0025136","volume":"6","author":"Simm C.","year":"2011","journal-title":"PLoS One"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1042\/BST0391527","volume":"39","author":"De Brucker K.","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.drudis.2014.06.009","volume":"19","author":"Wong S. S. W.","year":"2014","journal-title":"Drug Discovery Today."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0957-4166(96)00527-7","volume":"8","author":"Effenberg F.","year":"1997","journal-title":"Tetrahedron: Asymmetry"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1021\/jo01020a023","volume":"30","author":"Bottini A.","year":"1965","journal-title":"J. Org. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"17711","DOI":"10.1016\/S0040-4020(97)10235-6","volume":"53","author":"Remuzon P.","year":"1997","journal-title":"Tetrahedron"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1055\/s-2004-822406","author":"Heydari A.","year":"2004","journal-title":"Synthesis"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2133\/dmpk.DMPK-12-RV-042","volume":"27","author":"Fukami T.","year":"2012","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1021\/cr200060g","volume":"111","author":"Barreiro E. J.","year":"2011","journal-title":"Chem. Rev."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1021\/jm300349j","volume":"55","author":"Duranti A.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1021\/tx200168d","volume":"24","author":"Stepan A. F.","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-pharmtox-010510-100514","volume":"51","author":"Walsh J. S.","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.pharmtox.45.120403.100010","volume":"45","author":"Kim D.","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1021\/cr950066q","volume":"96","author":"Patani G.","year":"1996","journal-title":"Chem. Rev."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/jm1013693","volume":"54","author":"Meanwell N.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4103\/0378-6323.86475","volume":"77","author":"Singal A.","year":"2011","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1128\/AAC.00280-11","volume":"55","author":"Bink A.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1093\/jac\/dku198","volume":"69","author":"Jacobsen I. D.","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/genetics\/134.3.717","volume":"134","author":"Fonzi W. A.","year":"1993","journal-title":"Genetics"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1073\/pnas.0611195104","volume":"104","author":"Kaur R.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.peptides.2005.01.008","volume":"26","author":"Thevissen K.","year":"2005","journal-title":"Peptides"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.2174\/092986709788612701","volume":"16","author":"Thevissen K.","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"12243","DOI":"10.3390\/molecules171012243","volume":"17","author":"Delattin N.","year":"2012","journal-title":"Molecules"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2006.04.003","volume":"106","author":"Cos P.","year":"2006","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm501814x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T22:49:44Z","timestamp":1680821384000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm501814x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2,12]]}},"alternative-id":["10.1021\/jm501814x"],"URL":"https:\/\/doi.org\/10.1021\/jm501814x","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}