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Med."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.1215966","volume":"336","author":"Cheeseman I. H.","year":"2012","journal-title":"Science"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","volume":"379","author":"Phyo A. P.","year":"2012","journal-title":"Lancet"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.1021\/cr500543f","volume":"114","author":"Barnett D. S.","year":"2014","journal-title":"Chem. Rev."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"11164","DOI":"10.1021\/cr500123g","volume":"114","author":"Teixeira C.","year":"2014","journal-title":"Chem. Rev."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1002\/anie.200200569","volume":"42","author":"Wiesner J.","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molbiopara.2010.08.005","volume":"175","author":"Crowther G. J.","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"e1805","DOI":"10.1371\/journal.pntd.0001805","volume":"6","author":"Witschel M.","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/cmdc.201100441","volume":"7","author":"Mombelli P.","year":"2012","journal-title":"ChemMedChem"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/anie.201309557","volume":"53","author":"Kunfermann A.","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1002\/anie.201311162","volume":"53","author":"Reker D.","year":"2014","journal-title":"Angew. Chem., Int. 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Parasitol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1111\/j.1742-4658.2009.07111.x","volume":"276","author":"Sopitthummakhun K.","year":"2009","journal-title":"FEBS J."},{"key":"ref23\/cit23","unstructured":"Witschel, M.; Stelzer, F.; Hutzler, J.; Qu, T.; Mietzner, T.; Kreuz, K.; Grossmann, K.; Aponte, R.; H\u00f6ffken, H. W.; Carlo, F.; Ehrhardt, T.; Simon, A.; Parra, R. L.Pyrazolopyrans having herbicidal and pharmaceutical properties. PCT Int. Appl. WO 2013182472 A1, 2013."},{"key":"ref24\/cit24","unstructured":"Drewry, D. H.; Hunter, R. N., III; Jung, D. K.; Linn, J. A.; Sehon, C.; Stavenger, R. A.Benzamide rho-kinase (ROCK-1) inhibitors;N-(2-phenylethyl)-5-(4-pyridinyl)-2-thiophenecarboxamide. US 2008293716, 2008."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1021\/ja809220j","volume":"131","author":"Moebius D. C.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1021\/ol070515w","volume":"9","author":"Javed M. I.","year":"2007","journal-title":"Org. Lett."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/cber.19731060323","volume":"106","author":"Junek H.","year":"1973","journal-title":"Chem. Ber."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/cber.19620950526","volume":"95","author":"Staab H. A.","year":"1962","journal-title":"Chem. Ber."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1107\/S1399004714005598","volume":"70","author":"Chitnumsub P.","year":"2014","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1111\/febs.12803","volume":"281","author":"Pinthong C.","year":"2014","journal-title":"FEBS J."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1107\/S1399004714023128","volume":"70","author":"Chitnumsub P.","year":"2014","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.1073\/pnas.1118370109","volume":"109","author":"Derbyshire E. R.","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/374269a0","volume":"374","author":"Dorn A.","year":"1995","journal-title":"Nature"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager W.","year":"1976","journal-title":"Science"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0001-706X(93)90083-N","volume":"55","author":"Huber W.","year":"1993","journal-title":"Acta Trop."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2004.04.007","volume":"137","author":"Franke-Fayard B.","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1128\/AAC.00519-09","volume":"53","author":"Jimenez-Diaz M. B.","year":"2009","journal-title":"Antimicrob. 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