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J. Pathol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"17405","DOI":"10.1074\/jbc.M007475200","volume":"276","author":"Brandstetter H.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1517\/13543776.15.3.253","volume":"15","author":"Breuer E.","year":"2005","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0162-0134(99)00245-7","volume":"79","author":"O\u2019Brien E. C.","year":"2000","journal-title":"J. Inorg. Biochem."},{"key":"ref15\/cit15","first-page":"99","volume-title":"Antimicrobial Pharmacodynamics in Theory and Clinical Practice","author":"McNabb J.","year":"2002"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-3659(97)00165-X","volume":"54","author":"Hoffman A.","year":"1998","journal-title":"J. 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