{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:25:02Z","timestamp":1789881902321,"version":"4.0.1"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2008,4,1]]},"DOI":"10.1021\/jm701307j","type":"journal-article","created":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T06:00:31Z","timestamp":1205820031000},"page":"2208-2215","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis and Evaluation of Novel Polyaminocarboxylate-Based Antitumor Agents"],"prefix":"10.1021","volume":"51","author":[{"given":"Hyun-Soon","family":"Chong","sequence":"first","affiliation":[{"name":"Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisung","family":"Lee","sequence":"additional","affiliation":[{"name":"Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Bui","sequence":"additional","affiliation":[{"name":"Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun A.","family":"Song","sequence":"additional","affiliation":[{"name":"Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Birch","sequence":"additional","affiliation":[{"name":"Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,3,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2174\/0929867033457638","volume":"10","author":"Buss J. L.","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"ref2\/cit2","volume-title":"Free radicals in biological and medicine","author":"Halliwell B.","year":"1989"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1124\/pr.57.4.2","volume":"57","author":"Kalinowski D. S.","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1056\/NEJM198810203191603","volume":"319","author":"Stevens R. G.","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0304-3835(92)90239-R","volume":"62","author":"Siegers C. P.","year":"1992","journal-title":"Cancer Lett."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2174\/0929867033457638","volume":"10","author":"Buss J. L.","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mrfmmm.2003.08.023","volume":"533","author":"Huang X.","year":"2003","journal-title":"Mutat. Res."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0140-6736(80)90440-7","volume":"2","author":"Faulk W. P.","year":"1980","journal-title":"Lancet"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0022-5347(17)39970-6","volume":"143","author":"Keer H. N.","year":"1990","journal-title":"J. Urol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1385\/BTER:95:1:19","volume":"95","author":"Kucharzewski M.","year":"2003","journal-title":"Biol. Trace Elem. Res."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1136\/gut.2006.094060","volume":"55","author":"Brookes M. J.","year":"2006","journal-title":"Gut"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"8072","DOI":"10.1021\/jo0204911","volume":"67","author":"Chong H. S.","year":"2002","journal-title":"J. Org. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1021\/jm040076w","volume":"47","author":"Chong H. S.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1517\/13543776.16.11.1533","volume":"16","author":"Birch N.","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jsgi.2005.11.004","volume":"13","author":"Alvero A. B.","year":"2006","journal-title":"J. Soc. Gynecol. Invest."},{"key":"ref16\/cit16","first-page":"461","volume":"4","author":"Krishna G.","year":"1999","journal-title":"Pharm. Dev. Technol."},{"key":"ref17\/cit17","first-page":"2967","volume":"104","author":"Le N. T.","year":"2004","journal-title":"Blood"},{"key":"ref18\/cit18","first-page":"1749","volume":"47","author":"Blatt J.","year":"1987","journal-title":"Cancer Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood.V64.3.748.748","volume":"64","author":"Lederman H. M.","year":"1984","journal-title":"Blood"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1182\/blood.V69.3.757.757","volume":"69","author":"Estrov Z.","year":"1987","journal-title":"Blood"},{"key":"ref21\/cit21","first-page":"104","volume":"3","author":"Dezza L.","year":"1989","journal-title":"Leukemia"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"12970","DOI":"10.1016\/S0021-9258(18)90642-3","volume":"259","author":"Bridges K. R.","year":"1984","journal-title":"J. Biol. Chem."},{"key":"ref23\/cit23","first-page":"233","volume":"19","author":"Shen L.","year":"2005","journal-title":"In Vivo"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ygyno.2005.07.129","volume":"100","author":"Brard L","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1600-0609.1986.tb02282.x","volume":"36","author":"Pippard M. J.","year":"1986","journal-title":"Scand. J. Haematol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1021\/jm0200759","volume":"45","author":"Chong H. S.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27a","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1021\/jm070401q","volume":"51","author":"Chong H. S.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27b","unstructured":"bThe synthesis and characterization of C-NETA and C-NE3TA analogues will be reported elsewhere."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1021\/ja953771p","volume":"118","author":"Huskens J.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/jo00060a027","volume":"58","author":"Richard H.","year":"1993","journal-title":"J. Org. Chem."},{"key":"ref30\/cit30","first-page":"2201","volume":"14","author":"Kumpaty H. J.","year":"2003","journal-title":"Synthesis"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3727\/095535491820873191","volume":"3","author":"Cory A. H.","year":"1991","journal-title":"Cancer Commun."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm701307j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T04:53:28Z","timestamp":1679374408000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm701307j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,18]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,4,1]]}},"alternative-id":["10.1021\/jm701307j"],"URL":"https:\/\/doi.org\/10.1021\/jm701307j","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,18]]}}}