{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T05:58:02Z","timestamp":1738130282026,"version":"3.33.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2008,3,1]]},"DOI":"10.1021\/jm7014765","type":"journal-article","created":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T06:00:25Z","timestamp":1204351225000},"page":"1817-1823","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis of a Potent and Selective<sup>18<\/sup>F-Labeled \u03b4-Opioid Receptor Antagonist Derived from the Dmt-Tic Pharmacophore for Positron Emission Tomography Imaging"],"prefix":"10.1021","volume":"51","author":[{"given":"Eun Kyoung","family":"Ryu","sequence":"first","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence H.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa, D.","family":"Marczak","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ambo","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severo","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuancheng","family":"Ren","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Balboni","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, Korea Basic Science Institute, Chuncheon Center, Korea, Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Tohoku Pharmaceutical University, 4-1, Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Department of Pharmaceutical..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0031-6997(24)01416-9","volume":"51","author":"Quock R. M.","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1124\/mi.6.3.7","volume":"6","author":"Jutkiewicz E. M.","year":"2006","journal-title":"Mol. Interventions"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.peptides.2007.10.012","volume":"29","author":"Vergura R.","year":"2008","journal-title":"Peptides"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1038\/sj.bjp.0707497","volume":"152","author":"Aguila B.","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1054\/npep.2002.0900","volume":"36","author":"Gav\u00e9riaux-Ruff C.","year":"2002","journal-title":"Neuropeptides"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-2999(00)00209-0","volume":"396","author":"Hudzik T. J.","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0006-8993(00)03302-3","volume":"893","author":"Mathieu-Kia A. M.","year":"2001","journal-title":"Brain Res."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1124\/pr.56.3.2","volume":"23","author":"Tegeder I.","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1124\/jpet.105.092742","volume":"316","author":"Watson M. J.","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1124\/jpet.103.049346","volume":"306","author":"Pol O.","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm908","volume":"9","author":"Stein C.","year":"2003","journal-title":"Nat. Med."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2174\/1381612003399987","volume":"6","author":"Gibson R. E.","year":"2000","journal-title":"Curr. Pharm. Des."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2174\/1381612043452992","volume":"10","author":"Ravert H. T.","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/00004647-199909000-00003","volume":"19","author":"Smith J. S.","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0960-894X(01)00112-3","volume":"11","author":"Clayson J.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nucmedbio.2003.10.002","volume":"31","author":"Chen X.","year":"2004","journal-title":"Nucl. Med. Biol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1097\/00001756-200007140-00005","volume":"11","author":"Monory K.","year":"2000","journal-title":"NeuroReport"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1021\/jm010449i","volume":"45","author":"Balboni G.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.104.077321","volume":"313","author":"Tryoen-T\u00f3th P.","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1021\/jm060741w","volume":"49","author":"Balboni G.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1021\/jm060343t","volume":"49","author":"V\u00e1zquez M. E.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bmc.2007.02.039","volume":"15","author":"Balboni G.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1021\/jm0504959","volume":"48","author":"Balboni G.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1021\/jm0700013","volume":"50","author":"Duval R. A.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00259-002-0897-z","volume":"29","author":"Villemagne P. S. R.","year":"2002","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2967\/jnumed.106.038778","volume":"48","author":"Madar I.","year":"2007","journal-title":"J. Nucl. Med."},{"key":"ref27\/cit27","first-page":"280P","volume":"43","author":"Villemagne P. M.","year":"2002","journal-title":"J. Nucl. Med."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s00259-007-0427-0","volume":"34","author":"Wu Z.","year":"2007","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.2967\/jnumed.107.040816","volume":"48","author":"Wu Z.","year":"2007","journal-title":"J. Nucl. Med."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1021\/jm00108a017","volume":"34","author":"Lazarus L. H.","year":"1991","journal-title":"J. Med. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0196-9781(93)90006-3","volume":"14","author":"Lazarus L. H.","year":"1993","journal-title":"Peptides"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1016\/S0021-9258(18)94026-3","volume":"264","author":"Lazarus L. H.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng Y. C.","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0968-0896(02)00601-6","volume":"11","author":"Sasaki Y.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"ref35\/cit35","first-page":"48","volume":"14","author":"Arunlakshana Q.","year":"1959","journal-title":"Br. J. Pharmacol."},{"key":"ref36\/cit36","first-page":"266","volume":"33","author":"Kosterlitz H. W.","year":"1968","journal-title":"Br. J. Pharmacol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm7014765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:18:16Z","timestamp":1738099096000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm7014765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,1]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,3,1]]}},"alternative-id":["10.1021\/jm7014765"],"URL":"https:\/\/doi.org\/10.1021\/jm7014765","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"type":"print","value":"0022-2623"},{"type":"electronic","value":"1520-4804"}],"subject":[],"published":{"date-parts":[[2008,3,1]]}}}