{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:12:17Z","timestamp":1787001137643,"version":"build-2736575974"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2008,8,1]]},"DOI":"10.1021\/jm8003575","type":"journal-article","created":{"date-parts":[[2008,7,12]],"date-time":"2008-07-12T02:00:39Z","timestamp":1215828039000},"page":"4844-4848","source":"Crossref","is-referenced-by-count":27,"title":["Selectivity Determinants of Inhibitor Binding to Human 20\u03b1-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid"],"prefix":"10.1021","volume":"51","author":[{"given":"Urmi","family":"Dhagat","sequence":"first","affiliation":[{"name":"Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, Laboratory of Biochemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Endo","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, Laboratory of Biochemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Sumii","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, Laboratory of Biochemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hara","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, Laboratory of Biochemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama","family":"El-Kabbani","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, Laboratory of Biochemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,7,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/humupd\/dmg022","volume":"9","author":"Penning T. M.","year":"2003","journal-title":"Hum. Reprod. Update"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj3260625","volume":"326","author":"Jez J. M.","year":"1997","journal-title":"Biochem. J."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0009-2797(00)00295-7","volume":"130","author":"Jez J. M.","year":"2001","journal-title":"Chem. Biol. Interact."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0009-2797(02)00164-3","volume":"143","author":"Oppermann U.","year":"2003","journal-title":"Chem.\u2212Biol. Interact."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0039-128X(96)00167-5","volume":"62","author":"Penning T. M.","year":"1997","journal-title":"Steroids"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1042\/bj3510067","volume":"351","author":"Penning T. M.","year":"2000","journal-title":"Biochem. J."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2003.11.006","volume":"215","author":"Penning T. M.","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1358\/dnp.2004.17.9.872570","volume":"17","author":"Bauman D. R.","year":"2004","journal-title":"Drug News Perspect."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1677\/jme.0.0250221","volume":"25","author":"Zhang Y.","year":"2000","journal-title":"J. Mol. Endocrinol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2407-4-27","volume":"4","author":"Lewis M. J.","year":"2004","journal-title":"BMC Cancer"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1210\/me.2004-0302","volume":"19","author":"Piekorz R. P.","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0165-6147(00)89058-6","volume":"16","author":"Lambert J. J.","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0009-2797(02)00206-5","volume":"143","author":"Higaki Y.","year":"2003","journal-title":"Chem. Biol. Interact."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.pbb.2006.05.020","volume":"84","author":"Eser D.","year":"2006","journal-title":"Pharmacol., Biochem. Behav."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1017\/S0022029905001214","volume":"72","author":"Wiebe J. P.","year":"2005","journal-title":"J. Dairy Res."},{"key":"ref16\/cit16","first-page":"301","volume":"54","author":"Deng H. B.","year":"2004","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/ijc.22402","volume":"120","author":"Wang H. W.","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mce.2005.10.009","volume":"248","author":"Rizner T. L.","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bcp.2007.08.034","volume":"75","author":"Selga E.","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2174\/157340607782360399","volume":"3","author":"Dhagat U.","year":"2007","journal-title":"Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0022-2836(68)90205-2","volume":"33","author":"Matthews B. W.","year":"1968","journal-title":"J. Mol. Biol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0022-2836(03)00762-9","volume":"331","author":"Couture J. F.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1007\/s00018-007-6514-3","volume":"64","author":"El-Kabbani O.","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1021\/jm050412o","volume":"48","author":"El-Kabbani O.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1021\/jm050424+","volume":"48","author":"Petrova T.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1042\/bj3360429","volume":"336","author":"Matsuura K.","year":"1998","journal-title":"Biochem. J."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/bj3230061","volume":"323","author":"Matsuura K.","year":"1997","journal-title":"Biochem. J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/bj3340399","volume":"334","author":"Shiraishi H.","year":"1998","journal-title":"Biochem. J."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/oxfordjournals.jbchem.a022211","volume":"124","author":"Matsuura K.","year":"1998","journal-title":"J. Biochem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/oxfordjournals.jbchem.a124904","volume":"118","author":"Deyashiki Y.","year":"1995","journal-title":"J. Biochem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"Collaborative Computational Project N.","year":"1994","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley P.","year":"2004","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"Murshudov G. N.","year":"1997","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","volume":"24","author":"Kraulis P.","year":"1991","journal-title":"J. Appl. Crystallogr."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm8003575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T17:07:14Z","timestamp":1678208834000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm8003575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,12]]},"references-count":35,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2008,8,1]]}},"alternative-id":["10.1021\/jm8003575"],"URL":"https:\/\/doi.org\/10.1021\/jm8003575","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,12]]}}}