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Lett."},{"key":"ref26\/cit26d","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1016\/j.bmcl.2006.05.031","volume":"16","author":"Ku I. W.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref26\/cit26e","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bmc.2006.09.051","volume":"15","author":"Jo M. N.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref26\/cit26f","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.bmc.2006.10.013","volume":"15","author":"Doddareddy M. R.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref26\/cit26g","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.bmc.2006.11.004","volume":"15","author":"Park J. H.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref26\/cit26h","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1016\/j.bmcl.2007.08.070","volume":"17","author":"Seo H. N.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1021\/jm800419w","volume":"51","author":"Shipe W. D.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","unstructured":"SeeSupporting Informationfor assay details."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/adt.2006.054","volume":"5","author":"Xie X.","year":"2007","journal-title":"Assay Drug Dev. Technol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/eurheartj\/ehi092","volume":"26","author":"De Bruin M. L.","year":"2005","journal-title":"Eur. Heart J."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.bmcl.2005.12.021","volume":"16","author":"Raab C. E.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref32\/cit32","unstructured":"Butcher, J. W.; Claremon, D. A.; Connolly, T. M.; Dean, D. C.; Karczewski, J.; Koblan, K. S.; Kostura, M. J.; Liverton, N. J.; Melillo, D. G.Radioligand and Binding Assay. PCT Int. Appl. WO 2002005860, 2002."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00005344-198702000-00008","volume":"9","author":"Schoemaker H.","year":"1987","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0920-1211(92)90029-S","volume":"12","author":"Coenen A. M. L.","year":"1992","journal-title":"Epilepsy Res."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"12329","DOI":"10.1073\/pnas.210244497","volume":"97","author":"Mitcheson J. S.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0960-894X(03)00196-3","volume":"13","author":"Pearlstein R. A.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1021\/jm981133m","volume":"42","author":"van Niel M. B.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/jm060983w","volume":"50","author":"Liverton N. J.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/ol049672a","volume":"6","author":"Yin J.","year":"2004","journal-title":"Org. Lett."},{"key":"ref40\/cit40","unstructured":"Nelson, T. D.; Kress, M. H.; Krska, S. W.; Mitten, J. V.; Sun, Y.Process for Preparation of Chiral Piperidines via Asymmetric Hydrogenation of Dehydropiperidines Using Metal Chiral Phosphine Catalyst Complexes. PCT Int. Appl. 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