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U.S.A."},{"key":"ref10\/cit10","unstructured":"The X-ray diffraction data of the K103N RT and inhibitor8dcomplex crystal (Figure 4) were collected at 3.15 \u00c5 resolution withRsymof 0.085 and 100% completeness. The structure was refined to anR-factor of 0.184. The structure has been deposited in the PDB; PDB code is3DRS."},{"key":"ref12\/cit12","volume-title":"Abstracts of Papers","author":"Dykes C.","year":"2007"},{"key":"ref13\/cit17","volume-title":"Distance Geometry and Molecular Conformation","author":"Crippen C. M.","year":"1988"},{"key":"ref13\/cit18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF02192799","volume":"2","author":"Kuszewski J.","year":"1992","journal-title":"J. Biomol. NMR"},{"key":"ref13\/cit19","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1021\/ci000464g","volume":"41","author":"Feuston B. P.","year":"2001","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref13\/cit20","first-page":"490, 520, 553,","volume":"17","author":"Halgren T. A.","year":"1996","journal-title":"J. Comput. Chem."},{"key":"ref13\/cit21","first-page":"587","volume":"17","author":"Halgren T. A.","year":"1996","journal-title":"J. Comput. Chem."},{"key":"ref13\/cit22","unstructured":"fPyMol, version 99, distributed by DeLano Scientific LLC, was utilized to generate all images."},{"key":"ref14\/cit14","unstructured":"The X-ray diffraction data of the wild type RT and inhibitor8ecomplex crystal (Figure5) was collected at 2.6 \u00c5 resolution withRsymof 0.057 and 100% completeness. The structure was refined to anR-factor of 0.187. The structure has been deposited in the PDB; PDB code is3DRP. The X-ray diffraction data of the Y181C RT and inhibitor8ecomplex crystal (Figure6) was collected at 2.9 \u00c5 resolution withRsymof 0.067 and 100% completeness. The structure was refined to anR-factor of 0.183. 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