{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:16:21Z","timestamp":1792016181422,"version":"4.4.0"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2009,2,26]]},"DOI":"10.1021\/jm801406h","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T14:58:14Z","timestamp":1233759494000},"page":"1081-1099","source":"Crossref","is-referenced-by-count":40,"title":["Pyrido[2,3-<i>d<\/i>]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors"],"prefix":"10.1021","volume":"52","author":[{"given":"Hui","family":"Huang","sequence":"first","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Hutta","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Rinker","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaping","family":"Hu","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schubert","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee L.","family":"DesJarlais","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl S.","family":"Crysler","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery A.","family":"Chaikin","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Donatelli","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Chen","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Yurkow","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl L.","family":"Manthey","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Player","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1073\/pnas.83.10.3331","volume":"83","author":"Sacca R.","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","volume":"14","author":"Pixley F. J.","year":"2004","journal-title":"Trends Cell Biol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1084\/jem.156.5.1516","volume":"156","author":"Wiktor-Jedrzejczak W.","year":"1982","journal-title":"J. Exp. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1064-2722(08)60060-2","volume":"4","author":"Pollard J. W.","year":"1995","journal-title":"Adv. Dev. Biochem."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.4049\/jimmunol.175.3.1399","volume":"175","author":"MacDonald K. P. A.","year":"2005","journal-title":"J. Immunol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","volume":"14","author":"Pixley F. J.","year":"2004","journal-title":"Trends Cell Biol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/art.10359","volume":"46","author":"Park Y.","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0049-0172(91)90021-Q","volume":"20","author":"Joffe I.","year":"1991","journal-title":"Semin. Arthritis Rheum."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM200011303432202","volume":"343","author":"Lipsky P. E.","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.semarthrit.2003.12.003","volume":"34","author":"Borchers A. T.","year":"2004","journal-title":"Semin. Arthritis Rheum."},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1272\/jnms1923.62.260","volume":"62","author":"Kawaji H.","year":"1995","journal-title":"Nippon Ika Daigaku Zasshi"},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-3083.1994.tb03465.x","volume":"40","author":"Ritchlin C.","year":"1994","journal-title":"Scand. J. Immunol."},{"key":"ref10\/cit10c","first-page":"894","volume":"27","author":"Takei I.","year":"2000","journal-title":"J. Rheumatol."},{"key":"ref11\/cit11","first-page":"211","volume":"19","author":"Shinohara S.","year":"1992","journal-title":"J. Rheumatol."},{"key":"ref12\/cit12","first-page":"4084","volume":"54","author":"Weiner L. M.","year":"1994","journal-title":"Cancer Res."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0162-3109(96)00166-X","volume":"37","author":"Hanamura T.","year":"1997","journal-title":"Immunopharmacology"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/0140-6736(93)91653-4","volume":"342","author":"Hamilton J. A.","year":"1993","journal-title":"Lancet"},{"key":"ref15\/cit15a","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/BOR.0b013e3282f5fcf6","volume":"20","author":"Castro-Rueda H.","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref15\/cit15b","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/BOR.0b013e3283060778","volume":"20","author":"Ilowite N. T.","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref15\/cit15c","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1172\/JCI26132","volume":"115","author":"Kitaura H.","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref16\/cit16a","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jneuroim.2008.01.015","volume":"195","author":"Uemura Y.","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"ref16\/cit16b","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/eji.200737199","volume":"38","author":"Ohno H.","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"16078","DOI":"10.1073\/pnas.0502000102","volume":"102","author":"Conway J. G.","year":"2005","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1124\/jpet.107.129429","volume":"326","author":"Conway J. G.","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref18\/cit18","unstructured":"Ibrahim, P. N.; Artis, D. R.; Bremer, R.; Habets, G.; Mamo, S.; Nespi, M.; Zhang, C.; Zhang, J.; Zhu, Y.; Zuckerman, R.; West, B.; Suzuki, Y.; Tsai, J.; Hirth, K.P.; Bollag, G.; Spevak, W.; Cho, H.; Gillette, S. J.; Wu, G.; Zhu, H.; Shi, S.Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. PCT Int. Appl. WO 2007002433, 2007."},{"key":"ref19\/cit19","unstructured":"Ajami, A. M.; Boss, M. A.; Paterson, J.Treatment of autoimmune and demyelinating diseases with Symadex and related imidazoacridine derivatives. PCT Int. Appl. WO 2006081431, 2006."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1158\/1535-7163.MCT-05-0333","volume":"5","author":"Patyna S.","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.juro.2007.08.127","volume":"179","author":"Tamaskar I.","year":"2008","journal-title":"J. Urol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1158\/1535-7163.MCT-05-0359","volume":"5","author":"Guo J.","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref23\/cit23a","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.1016\/j.bmcl.2007.09.057","volume":"17","author":"Patch R. J.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref23\/cit23b","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.bmcl.2008.01.059","volume":"18","author":"Illig C. R.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref23\/cit23c","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1016\/j.bmcl.2008.04.059","volume":"18","author":"Meegalla S. K.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.bmcl.2008.01.088","volume":"18","author":"Wall M. J.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.bmcl.2008.02.070","volume":"18","author":"Huang H.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref26\/cit26","first-page":"585","volume":"9","author":"Pesson M.","year":"1974","journal-title":"Eur. J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1021\/jm010057b","volume":"45","author":"Tomita K.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","unstructured":"Ruesdale, L. K.; Sherbine, J. P.; Vanasse, B. J.Preparation of 2,4-dihydroxypyridine and 2,4-dihydroxy-3-nitropyridine and nucleoside derivatives useful for treating cardiovascular diseases. PCT Int. Appl. WO9724327A1, 1997."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1074\/jbc.M608182200","volume":"282","author":"Schalk-Hihi C.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1074\/jbc.M608183200","volume":"282","author":"Schubert C.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref31\/cit31","unstructured":"The Cerep high-throughput profile consists of a broad collection of 50 transmembrane and soluble receptors, ion channels, and monoamine transporters. It has been specifically designed to provide information not only on potential limitations or liabilities of drug candidates, but also for off-target activity identification. For the test compounds, the results are expressed as a percent inhibition of control specific binding (mean values,n= 2)."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.3987\/R-1986-12-3373","volume":"24","author":"Swindell C. S.","year":"1986","journal-title":"Heterocycles"},{"key":"ref33\/cit33a","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/stem.5530100403","volume":"10","author":"Ratajczak M. Z.","year":"1992","journal-title":"Int. J. Cell Cloning"},{"key":"ref33\/cit33b","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1182\/blood.V97.5.1413","volume":"97","author":"Smolich B. D.","year":"2001","journal-title":"Blood"},{"key":"ref34\/cit34a","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(88)90020-7","volume":"55","author":"Geissler E. N.","year":"1988","journal-title":"Cell"},{"key":"ref34\/cit34b","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1182\/blood-2005-05-2096","volume":"106","author":"Bijangi-Vishehsaraei K.","year":"2005","journal-title":"Blood"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1002\/j.1460-2075.1987.tb02599.x","volume":"6","author":"Orlofsky A.","year":"1987","journal-title":"EMBO J."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/mthe.2002.0808","volume":"6","author":"Chan J. M. K.","year":"2002","journal-title":"Mol. Ther."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1084\/jem.146.6.1585","volume":"146","author":"Cromartie W. J.","year":"1977","journal-title":"J. Exp. Med."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/rheumatology\/40.9.978","volume":"40","author":"Richards P. J.","year":"2001","journal-title":"Rheumatology"},{"key":"ref39\/cit39a","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/art.1780400206","volume":"40","author":"Tak P. P.","year":"1997","journal-title":"Arthritis Rheum."},{"key":"ref39\/cit39b","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/ard.2004.029751","volume":"64","author":"Haringman J. J.","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood.V99.1.111","volume":"99","author":"DAI x. m.","year":"2002","journal-title":"Blood"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1189\/jlb.68.1.144","volume":"68","author":"Campbell I. K.","year":"2000","journal-title":"J. Leukocyte Biol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1246\/bcsj.63.2820","volume":"63","author":"Tohda Y.","year":"1990","journal-title":"Bull. Chem. Soc. Jpn."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm801406h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T08:09:45Z","timestamp":1680854985000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm801406h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,4]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,2,26]]}},"alternative-id":["10.1021\/jm801406h"],"URL":"https:\/\/doi.org\/10.1021\/jm801406h","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,4]]}}}