{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:39:32Z","timestamp":1791322772123,"version":"4.3.1"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2009,10,8]]},"DOI":"10.1021\/jm900641r","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T18:20:49Z","timestamp":1252088449000},"page":"5990-5998","source":"Crossref","is-referenced-by-count":27,"title":["Carbonic Anhydrase Inhibitors. Comparison of Aliphatic Sulfamate\/Bis-sulfamate Adducts with Isozymes II and IX as a Platform for Designing Tight-Binding, More Isoform-Selective Inhibitors"],"prefix":"10.1021","volume":"52","author":[{"given":"Rosa Maria","family":"Vitale","sequence":"first","affiliation":[{"name":"Istituto di Chimica Biomolecolare\u2014CNR, Via Campi Flegrei 34, 80078, Pozzuoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Alterio","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2014CNR, Via Mezzocannone 16, 80134 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Winum","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, B\u00e2timent de Recherche Max Mousseron, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, 8 Rue de l\u2019Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona Maria","family":"Monti","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2014CNR, Via Mezzocannone 16, 80134 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"De Simone","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2014CNR, Via Mezzocannone 16, 80134 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2014CNR, Via Mezzocannone 16, 80134 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,9,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1967.47.4.595","volume":"47","author":"Maren T. H.","year":"1967","journal-title":"Physiol. Rev."},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"26233","DOI":"10.1016\/S0021-9258(19)74305-1","volume":"268","author":"Maren T. H.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0014-5793(94)00798-5","volume":"350","author":"H\u00e5kansson K.","year":"1994","journal-title":"FEBS Lett."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1021\/jm021124k","volume":"46","author":"Winum J.-Y.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1021\/jm030911u","volume":"46","author":"Winum J. -Y.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bmcl.2004.11.058","volume":"15","author":"Winum J.-Y.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran C. T.","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138161208783877947","volume":"14","author":"Supuran C. T.","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref7\/cit7b","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.bmcl.2008.03.051","volume":"18","author":"Temperini C.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref7\/cit7c","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1039\/b800767e","volume":"6","author":"Temperini C.","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","unstructured":"aSupuran, C. T.; Scozzafava, A.; Conway, J.Carbonic Anhydrase. Its Inhibitors and Activators;CRC Press:Boca Raton, FL, 2004; p1\u2212363.","DOI":"10.4324\/9780203475300"},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1002\/anie.200701189","volume":"46","author":"K\u00f6hler K.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova S.","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4324\/9780203475300","volume-title":"Carbonic Anhydrase. Its Inhibitors and Activators","author":"Supuran C. T.","year":"2004"},{"key":"ref9\/cit9c","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry A.","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1517\/13543776.14.5.667","volume":"14","author":"Scozzafava A.","year":"2004","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/138955706777934946","volume":"6","author":"Winum J. Y.","year":"2006","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref10\/cit10c","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1517\/13543776.13.10.1545","volume":"13","author":"Supuran C. T.","year":"2003","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/cr050262p","volume":"108","author":"Krishnamurthy V. M.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"16130","DOI":"10.1021\/ja805558k","volume":"130","author":"Stiti M.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2174\/138161208783877956","volume":"14","author":"Thiry A.","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref13\/cit13a","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1517\/14728214.13.2.383","volume":"13","author":"Supuran C. T.","year":"2008","journal-title":"Expert Opin. Emerging Drugs"},{"key":"ref13\/cit13b","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone G.","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref14\/cit14a","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio V.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref14\/cit14b","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2007.04.018","volume":"83","author":"Dubois L.","year":"2007","journal-title":"Radiother. Oncol."},{"key":"ref14\/cit14c","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1021\/jm800121c","volume":"51","author":"D'Ambrosio K.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref14\/cit14d","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1021\/jm701526d","volume":"51","author":"Thiry A.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca A.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref16\/cit16","first-page":"73","volume-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","author":"Alterio V.","year":"2009"},{"issue":"1","key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756360902784425","volume":"24","author":"Ebbesen P.","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-08-2470","volume":"69","author":"Chiche J.","year":"2009","journal-title":"Cancer Res."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah R. G.","year":"1971","journal-title":"J. Biol. Chem."},{"key":"ref19\/cit19a","first-page":"61","volume":"1","author":"Supuran C. T.","year":"2001","journal-title":"Curr. Med. Chem.: Immunol., Endocr. Metab. Agents"},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran C. T.","year":"2003","journal-title":"Med. Res. Rev."},{"key":"ref20\/cit20a","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/jm9900523","volume":"42","author":"Scozzafava A.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref20\/cit20b","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1021\/jm9901879","volume":"42","author":"Scozzafava A.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref20\/cit20c","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1021\/jm0108202","volume":"45","author":"Scozzafava A.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1016\/j.bmc.2007.08.037","volume":"15","author":"Nishimori I.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/prot.340040406","volume":"4","author":"Eriksson A. E.","year":"1988","journal-title":"Proteins: Struct. Funct."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1021\/ja00091a006","volume":"116","author":"Cappalonga Bunn A. M.","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger A. T.","year":"1998","journal-title":"Acta Crystallogr., Sect. D"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"Jones T. A.","year":"1991","journal-title":"Acta Crystallogr., Sect. A"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1107\/S0108768102003890","volume":"58","author":"Allen F. H.","year":"2002","journal-title":"Acta Crystallogr., Sect. B"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/nar\/gkg095","volume":"31","author":"Boeckmann B.","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1074\/jbc.M310809200","volume":"279","author":"Whittington D. A.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"Sali A.","year":"1993","journal-title":"J. Mol. Biol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1126\/science.1853201","volume":"253","author":"Bowie J. U.","year":"1991","journal-title":"Science"},{"key":"ref33\/cit33","volume-title":"AMBER 9","author":"Case D. A.","year":"2006"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/1096-987X(200009)21:12<1049::AID-JCC3>3.0.CO;2-F","volume":"21","author":"Wang J.","year":"2000","journal-title":"J. Comput. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1021\/j100142a004","volume":"97","author":"Bayly C. I.","year":"1993","journal-title":"J. Phys. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jcc.540141112","volume":"14","author":"Schmidt M. W.","year":"1993","journal-title":"J. Comput. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1021\/ja003796a","volume":"123","author":"Suarez D.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1021\/ja00022a010","volume":"113","author":"Hoops S. C.","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"Ryckaert J.-P.","year":"1997","journal-title":"J. Comput. Phys."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0263-7855(96)00009-4","volume":"14","author":"Koradi R.","year":"1996","journal-title":"J. Mol. Graphics"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm900641r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T05:29:47Z","timestamp":1678080587000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm900641r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,4]]},"references-count":57,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2009,10,8]]}},"alternative-id":["10.1021\/jm900641r"],"URL":"https:\/\/doi.org\/10.1021\/jm900641r","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,4]]}}}