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Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0889-8553(05)70218-1","volume":"30","author":"Cryer B.","year":"2001","journal-title":"Gastroenterol. Clin. North Am."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1053\/bega.2001.0229","volume":"15","author":"Wallace J. L.","year":"2001","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/S0002-9343(99)00113-8","volume":"106","author":"Whelton A.","year":"1999","journal-title":"Am. J. Med."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0960-894X(99)00288-7","volume":"9","author":"Prasit P.","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1021\/jm960803q","volume":"40","author":"Penning T. D.","year":"1997","journal-title":"J. Med. 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