{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:14:14Z","timestamp":1791652454173,"version":"4.3.4"},"reference-count":20,"publisher":"American Chemical Society (ACS)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2009,11,12]]},"DOI":"10.1021\/jm900907s","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T20:29:55Z","timestamp":1253305795000},"page":"6936-6940","source":"Crossref","is-referenced-by-count":87,"title":["Identification of Biphenyl-Based Hybrid Molecules Able To Decrease the Intracellular Level of Bcl-2 Protein in Bcl-2 Overexpressing Leukemia Cells"],"prefix":"10.1021","volume":"52","author":[{"given":"Daniela","family":"Pizzirani","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University and the Broad Institute of MIT and Harvard, 12 Oxford Street, Cambridge, Massachusetts 02138"},{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Roberti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Grimaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Di Cristina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria Maria","family":"Pipitone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlio","family":"Tolomeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Recanatini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,9,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1021\/jm060253o","volume":"49","author":"Roberti M.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cmdc.200700258","volume":"3","author":"Pizzirani D.","year":"2008","journal-title":"ChemMedChem"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1039\/b704729k","volume":"37","author":"Hubel K.","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.1016\/j.tetlet.2007.07.214","volume":"48","author":"Pizzirani D.","year":"2007","journal-title":"Tetrahedron Lett."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2174\/1385272033486404","volume":"7","author":"Brimble M. F.","year":"2003","journal-title":"Curr. Org. Chem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1039\/b603015g","volume":"4","author":"Zinzalla G. M.","year":"2006","journal-title":"Org. Biol. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1021\/cr050248c","volume":"106","author":"Liu J. K.","year":"2006","journal-title":"Chem. Rev."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1038\/sj.onc.1202591","volume":"17","author":"Reed J. C.","year":"1998","journal-title":"Oncogene"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm0697-614","volume":"3","author":"Kroemer G.","year":"1997","journal-title":"Nat. Med."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1073\/pnas.92.12.5287","volume":"92","author":"Sanchez-Garcia I.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11864-003-0022-y","volume":"4","author":"Schimmer A. D.","year":"2003","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.cdd.4400213","volume":"4","author":"McGahon A. J.","year":"1997","journal-title":"Cell Death Differ."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1097-4644(19960101)60:1<23::AID-JCB5>3.0.CO;2-5","volume":"60","author":"Reed J. C.","year":"1996","journal-title":"J. Cell. Biochem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00130404-200301000-00007","volume":"9","author":"Buchholz T. A.","year":"2003","journal-title":"Cancer J."},{"key":"ref15\/cit15","first-page":"307","volume":"3","author":"Bettaieb A.","year":"2003","journal-title":"Curr. Med. Chem.: Anti-Cancer Agents"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1586\/14737140.4.6.1157","volume":"4","author":"Gardner C. R.","year":"2004","journal-title":"Expert Rev. Anticancer Ther."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrd2324","volume":"6","author":"Quint\u00e0s-Cardama A.","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0028-1088370","volume":"75","author":"Tsolmon S.","year":"2009","journal-title":"Planta Med."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1182\/blood.V99.6.2199","volume":"99","author":"Dimberg A.","year":"2002","journal-title":"Blood"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/anie.200703073","volume":"47","author":"Nielsen T. E.","year":"2008","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm900907s","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T20:45:44Z","timestamp":1678135544000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm900907s"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,18]]},"references-count":20,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2009,11,12]]}},"alternative-id":["10.1021\/jm900907s"],"URL":"https:\/\/doi.org\/10.1021\/jm900907s","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,18]]}}}