{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:26:40Z","timestamp":1760783200979},"reference-count":21,"publisher":"American Chemical Society (ACS)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2009,11,12]]},"DOI":"10.1021\/jm9012278","type":"journal-article","created":{"date-parts":[[2009,10,16]],"date-time":"2009-10-16T17:38:09Z","timestamp":1255714689000},"page":"6535-6538","source":"Crossref","is-referenced-by-count":17,"title":["Discovery and Optimization of Substituted 1-(1-Phenyl-1<i>H<\/i>-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics"],"prefix":"10.1021","volume":"52","author":[{"given":"Steve F.","family":"Poon","sequence":"first","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"David J.","family":"St. Jean","sequence":"additional","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Charles","family":"Henley","sequence":"additional","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Davis","sequence":"additional","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Morony","sequence":"additional","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred D.","family":"Lott","sequence":"additional","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff D.","family":"Reagan","sequence":"additional","affiliation":[{"name":"Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny Ying-Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Fotsch","sequence":"additional","affiliation":[{"name":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2009,10,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"F253","DOI":"10.1152\/ajpcell.00014.2004","volume":"288","author":"Rodriguez M.","year":"2005","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"ref2\/cit2","unstructured":"Skorecki, K.; Green, J.; Brenner, B. M.InHarrison\u2019s Principles of Internal Medicine,16th ed.Kaspar, D. L.; Braunwald, E.; Fauci, A. S.; Hauser, S. L.; Longo, D. L.; Jameson, J. L., Eds.McGraw-Hill:New York, 2005; Vol.261, pp1653\u22121663."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1046\/j.1523-1755.1999.07304.x","volume":"73","author":"Slatopolosky E.","year":"1999","journal-title":"Kidney Int., Suppl."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/366575a0","volume":"366","author":"Brown E. M.","year":"1993","journal-title":"Nature"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.2001.81.1.239","volume":"81","author":"Brown E. M.","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"46622","DOI":"10.1074\/jbc.M207100200","volume":"277","author":"Hu J.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref7\/cit7","first-page":"115","volume":"4","author":"Bai M.","year":"1999","journal-title":"Int. J. Mol. Med."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1074\/jbc.271.11.5972","volume":"271","author":"Ruat M.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.med.57.121304.131328","volume":"57","author":"Hebert S. C.","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.2174\/092986707782794096","volume":"14","author":"Harrington P. E.","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1211\/002235703765344531","volume":"55","author":"Wu W.-N.","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0960-894X(00)00382-6","volume":"10","author":"Dauban P.","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1016\/j.bmcl.2004.03.056","volume":"14","author":"Kessler A.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2165\/00003495-200565020-00007","volume":"65","author":"Balfour J. A. B.","year":"2005","journal-title":"Drugs"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1073\/pnas.95.7.4040","volume":"95","author":"Nemeth E. F.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1523-1755.1998.00735.x","volume":"53","author":"Antonsen J. E.","year":"1998","journal-title":"Kidney Int."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1046\/j.1523-1755.61.s80.25.x","volume":"61","author":"Fraz\u00e3o J. M.","year":"2002","journal-title":"Kidney Int."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"Veber D. F","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0040-4039(00)95189-X","volume":"30","author":"Bringmann G.","year":"1989","journal-title":"Tetrahedron Lett."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3987\/COM-96-7657","volume":"45","author":"Holzer W.","year":"1997","journal-title":"Heterocycles"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1124\/jpet.103.057273","volume":"308","author":"Nemeth E. F.","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm9012278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T20:36:29Z","timestamp":1678134989000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm9012278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,16]]},"references-count":21,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2009,11,12]]}},"alternative-id":["10.1021\/jm9012278"],"URL":"https:\/\/doi.org\/10.1021\/jm9012278","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,16]]}}}