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Soc."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/protein\/12.4.271","volume":"12","author":"Betts M. J.","year":"1999","journal-title":"Protein Eng."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"Jones G.","year":"1997","journal-title":"J. Mol. Biol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1021\/bi00012a016","volume":"34","author":"Nair S. K.","year":"1995","journal-title":"Biochemistry"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio V.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1074\/jbc.M310809200","volume":"279","author":"Whittington D. A.","year":"2004","journal-title":"J. Biol. 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