{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:17:50Z","timestamp":1790399870829,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2010,2,11]]},"DOI":"10.1021\/jm9014845","type":"journal-article","created":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T20:17:40Z","timestamp":1263327460000},"page":"1190-1199","source":"Crossref","is-referenced-by-count":65,"title":["Isosorbide-2-benzyl Carbamate-5-salicylate, A Peripheral Anionic Site Binding Subnanomolar Selective Butyrylcholinesterase Inhibitor"],"prefix":"10.1021","volume":"53","author":[{"given":"Ciaran G.","family":"Carolan","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald P.","family":"Dillon","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Khan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila A.","family":"Ryder","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Gaynor","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Reidy","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Marquez","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Holland","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Gilmer","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland, and School of Science, Athlone Institute of Technology, Westmeath, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,1,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/cne.903250212","volume":"325","author":"Tago H.","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00702-007-0631-x","volume":"114","author":"Manoharan I.","year":"2007","journal-title":"J. Neural Transm."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0306-4522(01)00613-3","volume":"110","author":"Mesulam M. M.","year":"2002","journal-title":"Neuroscience"},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0006-8993(91)90508-S","volume":"540","author":"Carson K. A.","year":"1991","journal-title":"Brain Res."},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0197-0186(92)90189-X","volume":"21","author":"Arendt T.","year":"1992","journal-title":"Neurochem. Int."},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/gps.935","volume":"18","author":"Giacobini E.","year":"2003","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"17213","DOI":"10.1073\/pnas.0508575102","volume":"102","author":"Greig N. H.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s007020200089","volume":"109","author":"Giacobini E.","year":"2002","journal-title":"J. Neural Transm."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00008571-200304000-00008","volume":"13","author":"O\u2019Brien K. K.","year":"2003","journal-title":"Pharmacogenetics"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.0602922103","volume":"103","author":"Diamant S.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/taap.1997.8187","volume":"145","author":"Lynch T. J.","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref9\/cit9b","first-page":"1458","volume":"59","author":"Morton C. L.","year":"1999","journal-title":"Cancer Res."},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.2169\/internalmedicine.46.0049","volume":"46","author":"Iwasaki T.","year":"2007","journal-title":"Intern. Med."},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cbi.2008.03.009","volume":"175","author":"Li B.","year":"2008","journal-title":"Chem.\u2212Biol. Interact."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1021\/jm800564y","volume":"51","author":"Carolan C. G.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1021\/jm801094c","volume":"51","author":"Moriarty L. M.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"6588","DOI":"10.1021\/jm900561s","volume":"52","author":"Jones M.","year":"2009","journal-title":"J. Med. Chem."},{"issue":"1","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cbi.2008.05.013","volume":"175","author":"Carolan C. G.","year":"2008","journal-title":"Chem.\u2212Biol. Interact."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2133\/dmpk.21.173","volume":"21","author":"Imai T.","year":"2006","journal-title":"Drug. Metab. Pharmacokinet."},{"key":"ref16\/cit16a","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.154.3747.400","volume":"154","author":"Main A. R.","year":"1966","journal-title":"Science"},{"key":"ref16\/cit16b","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0076-6879(97)86013-2","volume":"286","author":"Feaster S. R.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref16\/cit16c","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1021\/jm010914b","volume":"44","author":"Rampa A.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1021\/bi020016x","volume":"41","author":"Bar-On P.","year":"2002","journal-title":"Biochemistry"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"41141","DOI":"10.1074\/jbc.M210241200","volume":"278","author":"Nicolet Y.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.1678899","volume":"253","author":"Sussman J. L.","year":"1991","journal-title":"Science"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"10507","DOI":"10.1021\/bi980536l","volume":"37","author":"Nachon F.","year":"1998","journal-title":"Biochemistry"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1073\/pnas.90.19.9031","volume":"90","author":"Harel M.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","volume":"19","author":"Morris G. M.","year":"1998","journal-title":"J. Comput. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1023\/A:1023888813526","volume":"16","author":"Sippl W.","year":"2002","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/1097-0134(20010201)42:2<182::AID-PROT50>3.0.CO;2-1","volume":"42","author":"Bartolucci C.","year":"2001","journal-title":"Proteins"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1432-1033.1996.00036.x","volume":"235","author":"Masson P.","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0167-4838(99)00115-6","volume":"1433","author":"Masson P.","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ref27\/cit27","first-page":"69","volume-title":"Butyrlcholinesterase, Its Functions and Inhibitors","author":"Grieg N. H.","year":"2003","edition":"1"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1111\/j.1432-1033.2004.04110.x","volume":"271","author":"Masson P.","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman G. L.","year":"1961","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm9014845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T14:36:16Z","timestamp":1678026976000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm9014845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,12]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,2,11]]}},"alternative-id":["10.1021\/jm9014845"],"URL":"https:\/\/doi.org\/10.1021\/jm9014845","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,12]]}}}