{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:07:24Z","timestamp":1792098444042,"version":"4.4.0"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2010,3,11]]},"DOI":"10.1021\/jm901852f","type":"journal-article","created":{"date-parts":[[2010,2,15]],"date-time":"2010-02-15T14:25:29Z","timestamp":1266243929000},"page":"2264-2276","source":"Crossref","is-referenced-by-count":35,"title":["Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors"],"prefix":"10.1021","volume":"53","author":[{"given":"Bing","family":"Li","sequence":"first","affiliation":[{"name":"Microbiotix Inc., One Innovation Drive, Worcester, Massachusetts 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramdas","family":"Pai","sequence":"additional","affiliation":[{"name":"Microbiotix Inc., One Innovation Drive, Worcester, Massachusetts 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Cardinale","sequence":"additional","affiliation":[{"name":"Microbiotix Inc., One Innovation Drive, Worcester, Massachusetts 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Butler","sequence":"additional","affiliation":[{"name":"Microbiotix Inc., One Innovation Drive, Worcester, Massachusetts 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norton P.","family":"Peet","sequence":"additional","affiliation":[{"name":"Microbiotix Inc., One Innovation Drive, Worcester, Massachusetts 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald T.","family":"Moir","sequence":"additional","affiliation":[{"name":"Microbiotix Inc., One Innovation Drive, Worcester, Massachusetts 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Bavari","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry L.","family":"Bowlin","sequence":"additional","affiliation":[{"name":"Microbiotix Inc., One Innovation Drive, Worcester, Massachusetts 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,2,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrd1694","volume":"4","author":"Burnett J. C.","year":"2005","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jat.903","volume":"23","author":"Paddle B. M.","year":"2003","journal-title":"J. Appl. Toxicol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/09674845.2005.11732685","volume":"62","author":"Clarke S. C.","year":"2005","journal-title":"Br. J. Biomed. Sci."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/0929867053202223","volume":"12","author":"Hicks R. P.","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref5\/cit5","first-page":"30","volume":"17","author":"Josko D.","year":"2004","journal-title":"Clin. Lab. Sci."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jama.285.8.1059","volume":"285","author":"Arnon S. S.","year":"2001","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1093\/ajhp\/61.suppl_6.S11","volume":"61","author":"Charles P. D.","year":"2004","journal-title":"Am. J. Health-Syst. Pharm."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1074\/jbc.M209821200","volume":"278","author":"Foran P. G.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.pharmtox.44.101802.121554","volume":"44","author":"Simpson L. L.","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0264-410X(01)00482-0","volume":"20","author":"Amersdorfer P.","year":"2002","journal-title":"Vaccine"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1073\/pnas.172229899","volume":"99","author":"Nowakowski A.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1002\/anie.200705531","volume":"47","author":"Willis B.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0014-5793(02)03738-9","volume":"532","author":"Schmidt J. J.","year":"2002","journal-title":"FEBS Lett."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1021\/jm800737y","volume":"51","author":"Solaja B. A.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1039\/b603099h","author":"Boldt G. E.","year":"2006","journal-title":"Chem. Commun."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1021\/ol0603211","volume":"8","author":"Boldt G. E.","year":"2006","journal-title":"Org. Lett."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/j.bmc.2009.03.013","volume":"17","author":"Moe S. T.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1128\/AAC.00141-09","volume":"53","author":"Roxas-Duncan V.","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.abb.2009.09.008","volume":"491","author":"Lai H.","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"e7730","DOI":"10.1371\/journal.pone.0007730","volume":"4","author":"Pang Y.-P.","year":"2009","journal-title":"PLoS One"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1016\/j.bmcl.2009.01.111","volume":"19","author":"Burnett J. C.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1074\/jbc.M608166200","volume":"282","author":"Burnett J. C.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1021\/jm061446e","volume":"50","author":"Burnett J. C.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bmcl.2009.10.129","volume":"20","author":"Capkova K.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3987\/COM-08-11516","volume":"79","author":"Wang C.","year":"2009","journal-title":"Heterocycles"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.chembiol.2007.03.014","volume":"14","author":"Silvaggi N. R.","year":"2007","journal-title":"Chem. Biol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1021\/bi8001067","volume":"47","author":"Silvaggi N. R.","year":"2008","journal-title":"Biochemistry"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/AEM.69.1.297-303.2003","volume":"69","author":"Schmidt J. J.","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nsmb711","volume":"11","author":"Panchal R. G.","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref30\/cit30","unstructured":"Butler, M. M.; Cardinale, S. C.; Li, B.; Pai, R.; Ruthel, G.; Nuss, J. E.; Wanner, L. M.; Park, J.B.; Rich, C.; Basu, A.; Mills, D.; Williams, J. D.; Peet, N. P.; Moir, D.; Bavari, S.; Bowlin, T. L.Unpublished results."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"8903","DOI":"10.1021\/bi060786z","volume":"45","author":"Fu Z.","year":"2006","journal-title":"Biochemistry"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"18883","DOI":"10.1074\/jbc.M801240200","volume":"283","author":"Kumaran D.","year":"2008","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm901852f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T16:38:44Z","timestamp":1678379924000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm901852f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,15]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,3,11]]}},"alternative-id":["10.1021\/jm901852f"],"URL":"https:\/\/doi.org\/10.1021\/jm901852f","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,15]]}}}