{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:11:58Z","timestamp":1760706718211},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[1996,1,1]]},"DOI":"10.1021\/jm960268u","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T06:00:31Z","timestamp":1027663231000},"page":"4044-4057","source":"Crossref","is-referenced-by-count":30,"title":["Structure\u2212Activity Relationships of a Series of Novel (Piperazinylbutyl)thiazolidinone Antipsychotic Agents Related to 3-[4-[4-(6-Fluorobenzo[<i>b<\/i>]thien-3-yl)-1-piperazinyl]butyl]-2,5,5-trimethyl-4- thiazolidinone Maleate"],"prefix":"10.1021","volume":"39","author":[{"given":"Nicholas J.","family":"Hrib","sequence":"first","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Jurcak","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah E.","family":"Bregna","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendra L.","family":"Burgher","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold B.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Kafka","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa L.","family":"Kerman","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Kongsamut","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim E.","family":"Roehr","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Szewczak","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann T.","family":"Woods-Kettelberger","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Corbett","sequence":"additional","affiliation":[{"name":"Neuroscience Therapeutic Area, Hoechst Marion Roussel, Inc., Bridgewater, New Jersey 08876"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[1996,9,27]]},"reference":[{"key":"jm960268ub00001\/jm960268ub00001_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0140-6736(95)90469-7","volume":"345","author":"Pickar D","year":"1995","journal-title":"Lancet"},{"key":"jm960268ub00002\/jm960268ub00002_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0959-4388(94)90080-9","volume":"4","author":"Andreasen N. A","year":"1994","journal-title":"Curr. Opin. Neurobiol."},{"key":"jm960268ub00003\/jm960268ub00003_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-6147(92)90041-4","volume":"13","author":"Reynolds G. P","year":"1992","journal-title":"Trends Pharmacol. Sci."},{"key":"jm960268ub00004\/jm960268ub00004_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1056\/NEJM199403103301006","volume":"330","author":"Carpenter W. T.","year":"1994","journal-title":"Engl. J. Med."},{"key":"jm960268ub00005\/jm960268ub00005_1","first-page":"90","volume":"4","author":"Marder S. R.","year":"1991","journal-title":"Schizophrenia Res."},{"key":"jm960268ub00006\/jm960268ub00006_1","first-page":"1486","volume":"148","author":"Davis K. L.","year":"1991","journal-title":"Am. J. Psychiatry"},{"key":"jm960268ub00007\/jm960268ub00007_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/070674378903400310","volume":"34","author":"Remington G","year":"1989","journal-title":"Can. J. Psychiatry"},{"key":"jm960268ub00008\/jm960268ub00008_1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.2165\/00003495-199040050-00007","volume":"40","author":"Fitton A.","year":"1990","journal-title":"Drugs"},{"key":"jm960268ub00009\/jm960268ub00009_1","first-page":"246","volume":"251","author":"Meltzer H. Y.","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm960268ub00010\/jm960268ub00010_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00449814","volume":"238","author":"Meltzer H. Y.","year":"1989","journal-title":"Eur. Arch. Psychiatr. Neurol. Sci."},{"key":"jm960268ub00011\/jm960268ub00011_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0773.1989.tb00589.x","volume":"64","author":"Ahlenius S","year":"1989","journal-title":"Pharmacol. Toxicol."},{"key":"jm960268ub00012\/jm960268ub00012_1","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/0024-3205(90)90365-X","volume":"47","author":"Hicks P. B","year":"1990","journal-title":"Life Sci."},{"key":"jm960268ub00013\/jm960268ub00013_1","first-page":"1866","volume":"34","author":"Lowe J. A.","year":"1991","journal-title":"J. Med. Chem."},{"key":"jm960268ub00014\/jm960268ub00014_1","first-page":"693","volume":"244","author":"Janssen P. A. J.","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm960268ub00015\/jm960268ub00015_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ddr.430220306","volume":"22","author":"Sanchez C.","year":"1991","journal-title":"Drug Dev. Res."},{"key":"jm960268ub00016\/jm960268ub00016_1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1021\/jm00007a009","volume":"38","author":"Strupczewski J. T.","year":"1995","journal-title":"J. Med. Chem."},{"key":"jm960268ub00016\/jm960268ub00016_2","first-page":"1413","volume":"274","author":"Szewczak M. R.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm960268ub00017\/jm960268ub00017_1","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1021\/jm00092a600","volume":"35","author":"Hrib N. J.","year":"1992","journal-title":"J. Med. Chem."},{"key":"jm960268ub00018\/jm960268ub00018_1","volume-title":"Abstracts of the Third International Brain Research Organization World Congress of Neuroscience","author":"Rogers K. L.","year":"1991"},{"key":"jm960268ub00019\/jm960268ub00019_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0091-3057(93)90079-9","volume":"45","author":"Corbett R.","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"jm960268ub00020\/jm960268ub00020_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1248\/yakushi1947.76.1_77","volume":"76","author":"Ishidate M.","year":"1956","journal-title":"J. Pharm. Soc. Jpn."},{"key":"jm960268ub00021\/jm960268ub00021_1","first-page":"102553","volume":"106","author":"Haga T.","year":"1987","journal-title":"Chem. Abstr."},{"key":"jm960268ub00022\/jm960268ub00022_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1021\/jm00153a010","volume":"29","author":"Yevich J. P.","year":"1986","journal-title":"J. Med. Chem."},{"key":"jm960268ub00023\/jm960268ub00023_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3987\/S-1984-02-0714","volume":"21","author":"Unangst P. C.","year":"1984","journal-title":"J. Heterocycl. Chem."},{"key":"jm960268ub00024\/jm960268ub00024_1","first-page":"815","volume":"24","author":"Unangst P. C.","year":"1987","journal-title":"J. Heterocycl. Chem."},{"key":"jm960268ub00025\/jm960268ub00025_1","first-page":"67110","volume":"106","author":"Perregard J. K.","year":"1987","journal-title":"Chem. Abstr."},{"key":"jm960268ub00026\/jm960268ub00026_1","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1021\/jo00986a008","volume":"37","author":"Beck J. R","year":"1972","journal-title":"J. Org. Chem."},{"key":"jm960268ub00027\/jm960268ub00027_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-2999(78)90251-0","volume":"50","author":"Costall B.","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"jm960268ub00028\/jm960268ub00028_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF00634146","volume":"50","author":"Protais P.","year":"1976","journal-title":"Psychopharmacology"},{"key":"jm960268ub00029\/jm960268ub00029_1","first-page":"1005","volume":"10","author":"Janssen P. A. J.","year":"1960","journal-title":"Arzneim-Forsch."},{"key":"jm960268ub00030\/jm960268ub00030_1","first-page":"497","volume":"8","author":"Lowe J. A.","year":"1988","journal-title":"Med. Res. Rev."},{"key":"jm960268ub00031\/jm960268ub00031_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00002826-198906000-00002","volume":"12","author":"Moore N. C.","year":"1989","journal-title":"Clin. Neuropharmacol."},{"key":"jm960268ub00032\/jm960268ub00032_1","first-page":"2314","volume":"37","author":"Hrib N. J.","year":"1994","journal-title":"J. Med. Chem."},{"key":"jm960268ub00033\/jm960268ub00033_1","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1523\/JNEUROSCI.05-09-02539.1985","volume":"5","author":"Chiodo L. A.","year":"1985","journal-title":"J. Neurosci."},{"key":"jm960268ub00034\/jm960268ub00034_1","first-page":"116","volume":"8","author":"Jann M. W.","year":"1988","journal-title":"Pharmacotherapy"},{"key":"jm960268ub00035\/jm960268ub00035_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00004714-198902000-00021","volume":"9","author":"Sovner R.","year":"1989","journal-title":"J. Clin. Psychopharmacol."},{"key":"jm960268ub00036\/jm960268ub00036_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/350614a0","volume":"350","author":"Van Tol H. H. M.","year":"1991","journal-title":"Nature"},{"key":"jm960268ub00037\/jm960268ub00037_1","first-page":"284","volume":"7","author":"Seeman P","year":"1992","journal-title":"Neuropsychopharmacology"},{"key":"jm960268ub00038\/jm960268ub00038_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0014-2999(93)90488-4","volume":"236","author":"Lahti R. A.","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"jm960268ub00039\/jm960268ub00039_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1358\/dof.1994.019.02.235616","volume":"19","author":"Moore N. A.","year":"1994","journal-title":"Drugs Future"},{"key":"jm960268ub00040\/jm960268ub00040_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ddr.430110304","volume":"11","author":"Huger F. P.","year":"1987","journal-title":"Drug Dev. Res."},{"key":"jm960268ub00041\/jm960268ub00041_1","first-page":"238","volume":"2","author":"File S. E","year":"1980","journal-title":"J. Neurosci. Meth."},{"key":"jm960268ub00042\/jm960268ub00042_1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ddr.430040209","volume":"4","author":"Gardner C. R.","year":"1984","journal-title":"Drug Dev. Res."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm960268u","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T03:58:49Z","timestamp":1633233529000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm960268u"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1,1]]},"references-count":43,"journal-issue":{"issue":"20","published-print":{"date-parts":[[1996,1,1]]}},"alternative-id":["10.1021\/jm960268u"],"URL":"https:\/\/doi.org\/10.1021\/jm960268u","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1,1]]}}}