{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:10:12Z","timestamp":1760782212831},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[1997,5,1]]},"DOI":"10.1021\/jm9604989","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:10:41Z","timestamp":1027660241000},"page":"1530-1538","source":"Crossref","is-referenced-by-count":13,"title":["Inhibition of Thyroid Hormone Uptake by Calcium Antagonists of the Dihydropyridine Class"],"prefix":"10.1021","volume":"40","author":[{"given":"Gerhard H.","family":"Scholz","sequence":"first","affiliation":[{"name":"Universit\u00e4t Leipzig, Zentrum f\u00fcr Innere Medizin, Medizinische Klinik und Poliklinik III, Abteilung Endokrinologie\/Diabetologie, Philipp-Rosenthal-Str. 27, D-04103 Leipzig, Germany, Universit\u00e4t Leipzig, Institut f\u00fcr Biochemie der Fakult\u00e4t f\u00fcr Biowissenschaften, Pharmazie und Psychologie, Talstr. 33, D-04103 Leipzig, Germany, and Bayer AG Leverkusen, Pharma Forschungszentrum, D-42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Vieweg","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Leipzig, Zentrum f\u00fcr Innere Medizin, Medizinische Klinik und Poliklinik III, Abteilung Endokrinologie\/Diabetologie, Philipp-Rosenthal-Str. 27, D-04103 Leipzig, Germany, Universit\u00e4t Leipzig, Institut f\u00fcr Biochemie der Fakult\u00e4t f\u00fcr Biowissenschaften, Pharmazie und Psychologie, Talstr. 33, D-04103 Leipzig, Germany, and Bayer AG Leverkusen, Pharma Forschungszentrum, D-42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Uhlig","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Leipzig, Zentrum f\u00fcr Innere Medizin, Medizinische Klinik und Poliklinik III, Abteilung Endokrinologie\/Diabetologie, Philipp-Rosenthal-Str. 27, D-04103 Leipzig, Germany, Universit\u00e4t Leipzig, Institut f\u00fcr Biochemie der Fakult\u00e4t f\u00fcr Biowissenschaften, Pharmazie und Psychologie, Talstr. 33, D-04103 Leipzig, Germany, and Bayer AG Leverkusen, Pharma Forschungszentrum, D-42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Thormann","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Leipzig, Zentrum f\u00fcr Innere Medizin, Medizinische Klinik und Poliklinik III, Abteilung Endokrinologie\/Diabetologie, Philipp-Rosenthal-Str. 27, D-04103 Leipzig, Germany, Universit\u00e4t Leipzig, Institut f\u00fcr Biochemie der Fakult\u00e4t f\u00fcr Biowissenschaften, Pharmazie und Psychologie, Talstr. 33, D-04103 Leipzig, Germany, and Bayer AG Leverkusen, Pharma Forschungszentrum, D-42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Klossek","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Leipzig, Zentrum f\u00fcr Innere Medizin, Medizinische Klinik und Poliklinik III, Abteilung Endokrinologie\/Diabetologie, Philipp-Rosenthal-Str. 27, D-04103 Leipzig, Germany, Universit\u00e4t Leipzig, Institut f\u00fcr Biochemie der Fakult\u00e4t f\u00fcr Biowissenschaften, Pharmazie und Psychologie, Talstr. 33, D-04103 Leipzig, Germany, and Bayer AG Leverkusen, Pharma Forschungszentrum, D-42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Goldmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Leipzig, Zentrum f\u00fcr Innere Medizin, Medizinische Klinik und Poliklinik III, Abteilung Endokrinologie\/Diabetologie, Philipp-Rosenthal-Str. 27, D-04103 Leipzig, Germany, Universit\u00e4t Leipzig, Institut f\u00fcr Biochemie der Fakult\u00e4t f\u00fcr Biowissenschaften, Pharmazie und Psychologie, Talstr. 33, D-04103 Leipzig, Germany, and Bayer AG Leverkusen, Pharma Forschungszentrum, D-42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-J\u00f6rg","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Leipzig, Zentrum f\u00fcr Innere Medizin, Medizinische Klinik und Poliklinik III, Abteilung Endokrinologie\/Diabetologie, Philipp-Rosenthal-Str. 27, D-04103 Leipzig, Germany, Universit\u00e4t Leipzig, Institut f\u00fcr Biochemie der Fakult\u00e4t f\u00fcr Biowissenschaften, Pharmazie und Psychologie, Talstr. 33, D-04103 Leipzig, Germany, and Bayer AG Leverkusen, Pharma Forschungszentrum, D-42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[1997,5,9]]},"reference":[{"key":"jm9604989b00001\/jm9604989b00001_1","first-page":"203","volume-title":"Werner & Ingbar's The Thyroid","author":"Davis P. J.","year":"1991"},{"key":"jm9604989b00002\/jm9604989b00002_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1210\/edrv-8-3-288","volume":"8","author":"Oppenheimer J. H.","year":"1987","journal-title":"Endocr. Rev."},{"key":"jm9604989b00003\/jm9604989b00003_1","first-page":"320","volume":"676","author":"Krenning R.","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"jm9604989b00004\/jm9604989b00004_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-5793(82)80900-9","volume":"140","author":"Krenning R.","year":"1982","journal-title":"FEBS Lett."},{"key":"jm9604989b00005\/jm9604989b00005_1","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1210\/endo-112-5-1754","volume":"112","author":"Cheng S. Y","year":"1983","journal-title":"Endocrinology"},{"key":"jm9604989b00006\/jm9604989b00006_1","first-page":"51","volume":"1051","author":"Osty J.","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"jm9604989b00007\/jm9604989b00007_1","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1210\/endo-119-6-2755","volume":"119","author":"Pontecorvi A.","year":"1986","journal-title":"Endocrinology"},{"key":"jm9604989b00008\/jm9604989b00008_1","first-page":"241","volume":"67","author":"Kastellakis A.","year":"1989","journal-title":"Mol. Cell. Endocrinol."},{"key":"jm9604989b00009\/jm9604989b00009_1","first-page":"1157","volume":"113","author":"Cheng S. Y","year":"1983","journal-title":"Endocrinology"},{"key":"jm9604989b00010\/jm9604989b00010_1","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1210\/endo-116-6-2621","volume":"116","author":"Alderson R.","year":"1985","journal-title":"Endocrinology"},{"key":"jm9604989b00011\/jm9604989b00011_1","first-page":"951","volume":"83","author":"Cheng S. Y.","year":"1986","journal-title":"Biochemistry"},{"key":"jm9604989b00012\/jm9604989b00012_1","first-page":"2476","volume":"132","author":"Samson M.","year":"1993","journal-title":"Endocrinology"},{"key":"jm9604989b00013\/jm9604989b00013_1","first-page":"66","volume":"17","author":"Samson M.","year":"1994","journal-title":"J. Endocrinol. Invest."},{"key":"jm9604989b00014\/jm9604989b00014_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0026-0495(93)90090-B","volume":"42","author":"Topliss D. J.","year":"1993","journal-title":"Metabolism"},{"key":"jm9604989b00015\/jm9604989b00015_1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1021\/jm00061a019","volume":"36","author":"Chalmers D. K.","year":"1993","journal-title":"J. Med. Chem."},{"key":"jm9604989b00016\/jm9604989b00016_1","first-page":"1216","volume":"130","author":"Kragie L.","year":"1992","journal-title":"Endocrinology"},{"key":"jm9604989b00017\/jm9604989b00017_1","first-page":"391","volume":"8","author":"Kragie L.","year":"1994","journal-title":"Mol. Endocrinol."},{"key":"jm9604989b00018\/jm9604989b00018_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1021\/jm00004a015","volume":"38","author":"Yokoyama N.","year":"1995","journal-title":"J. Med. Chem."},{"volume-title":"IX. International Congress of Endocrinology. P-05","year":"1992","author":"Scholz G. H.","key":"jm9604989b00019\/jm9604989b00019_1"},{"key":"jm9604989b00020\/jm9604989b00020_1","first-page":"205","volume":"1013","author":"Hughes B. P.","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"jm9604989b00021\/jm9604989b00021_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/edrv-1-2-140","volume":"1","author":"Cody V","year":"1980","journal-title":"Endocr. Rev."},{"key":"jm9604989b00022\/jm9604989b00022_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0165-6147(85)90014-8","volume":"6","author":"Cheung E. N. Y","year":"1985","journal-title":"Trends Pharmacol. Sci."},{"key":"jm9604989b00023\/jm9604989b00023_1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1021\/jm00217a001","volume":"20","author":"Dietrich S. W.","year":"1977","journal-title":"J. Med. Chem."},{"key":"jm9604989b00024\/jm9604989b00024_1","first-page":"682","volume":"2","author":"Jorgensen E. C","year":"1976","journal-title":"Pharmacol. Ther., Part B"},{"key":"jm9604989b00025\/jm9604989b00025_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/jm00189a002","volume":"22","author":"Andrea T. A.","year":"1979","journal-title":"J. Med. Chem."},{"key":"jm9604989b00026\/jm9604989b00026_1","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1016\/S0021-9258(19)70460-8","volume":"255","author":"Bolger M. B.","year":"1980","journal-title":"J. Biol. Chem."},{"key":"jm9604989b00027\/jm9604989b00027_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/jm00236a002","volume":"18","author":"Cody V","year":"1975","journal-title":"J. Med. Chem."},{"key":"jm9604989b00028\/jm9604989b00028_1","first-page":"8525","volume":"95","author":"Kollman P. A.","year":"1973","journal-title":"J. Am. Chem. Soc."},{"volume-title":"Quantenchemische Berechnungen zur konformativen Struktur konjugierter Biomolek\u00fcle. (Quantum Chemical Calculations on the Conformative Structure of Conjugated Biomolecules.) Pharmazie","year":"1975","author":"Hofmann H.-J.","key":"jm9604989b00029\/jm9604989b00029_1"},{"key":"jm9604989b00030\/jm9604989b00030_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1021\/jm00349a004","volume":"25","author":"Blaney J. M.","year":"1982","journal-title":"J. Med. Chem."},{"key":"jm9604989b00031\/jm9604989b00031_1","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1021\/ja00387a046","volume":"104","author":"Blaney J. M.","year":"1982","journal-title":"J. Am. Chem. Soc."},{"volume-title":"Symposium der Deutschen Gesellschaft f\u00fcr Endokrinologie","year":"1993","author":"Scholz G. H.","key":"jm9604989b00032\/jm9604989b00032_1"},{"key":"jm9604989b00033\/jm9604989b00033_1","first-page":"11","volume":"205","author":"Hofmann H.-J.","year":"1990","journal-title":"J. Mol. Struct. (THEOCHEM)"},{"key":"jm9604989b00034\/jm9604989b00034_1","first-page":"327","volume":"28","author":"Hofmann H.-J.","year":"1988","journal-title":"Chem."},{"key":"jm9604989b00035\/jm9604989b00035_1","first-page":"40","volume":"241","author":"Hofmann H.-J.","year":"1988","journal-title":"FEBS Lett."},{"key":"jm9604989b00036\/jm9604989b00036_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1021\/jm00344a007","volume":"25","author":"Fossheim R.","year":"1982","journal-title":"J. Med. Chem."},{"key":"jm9604989b00037\/jm9604989b00037_1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1021\/jm00186a029","volume":"23","author":"Triggle A. M.","year":"1980","journal-title":"J. Med. Chem."},{"key":"jm9604989b00038\/jm9604989b00038_1","first-page":"588","volume":"41","author":"Fossheim R","year":"1987","journal-title":"Acta Chem. Scand."},{"key":"jm9604989b00039\/jm9604989b00039_1","first-page":"790","volume":"39","author":"Fossheim R","year":"1985","journal-title":"Acta Chem. Scand."},{"key":"jm9604989b00040\/jm9604989b00040_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1021\/jm00397a005","volume":"31","author":"Fossheim R.","year":"1988","journal-title":"J. Med. Chem."},{"key":"jm9604989b00041\/jm9604989b00041_1","first-page":"94","volume":"2","author":"Scholz G. H.","year":"1992","journal-title":"Thyroid"},{"key":"jm9604989b00042\/jm9604989b00042_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/BF02987528","volume":"2","author":"Ritter S.","year":"1995","journal-title":"Environ. Sci. Pollut. Res."},{"volume-title":"CompuDrug Chemistry Ltd","year":"1994","author":"Version","key":"jm9604989b00043\/jm9604989b00043_1"},{"key":"jm9604989b00044\/jm9604989b00044_1","first-page":"2424","volume":"268","author":"Hamilton J. A.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"jm9604989b00045\/jm9604989b00045_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/protein\/8.2.127","volume":"8","author":"Wallace A. C.","year":"1995","journal-title":"Protein Eng."},{"key":"jm9604989b00046\/jm9604989b00046_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0021-9258(18)48501-8","volume":"267","author":"Wojtczak A.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"jm9604989b00047\/jm9604989b00047_1","first-page":"765","volume":"52","author":"Wojtczak A.","year":"1996","journal-title":"Acta Crystallogr."},{"volume-title":"Burlington","year":"1994","author":"Version","key":"jm9604989b00048\/jm9604989b00048_1"},{"key":"jm9604989b00049\/jm9604989b00049_1","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/0040-4020(80)80168-2","volume":"36","author":"Gasteiger J.","year":"1980","journal-title":"Tetrahedron"},{"key":"jm9604989b00050\/jm9604989b00050_1","first-page":"296","volume":"11","author":"Nicholls A.","year":"1991","journal-title":"Genet."},{"volume-title":"Ab Initio Molecular Orbital Theory","year":"1986","author":"Hehre W. J.","key":"jm9604989b00051\/jm9604989b00051_1"},{"volume-title":"Wavefunction Inc., Irvine, 1994","year":"1995","author":"Versions","key":"jm9604989b00052\/jm9604989b00052_1"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm9604989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T12:40:24Z","timestamp":1680871224000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm9604989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,1]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,5,1]]}},"alternative-id":["10.1021\/jm9604989"],"URL":"https:\/\/doi.org\/10.1021\/jm9604989","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"type":"print","value":"0022-2623"},{"type":"electronic","value":"1520-4804"}],"subject":[],"published":{"date-parts":[[1997,5,1]]}}}