{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T06:56:27Z","timestamp":1775372187922,"version":"3.50.1"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[1998,6,1]]},"DOI":"10.1021\/jm970298c","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:34:22Z","timestamp":1027661662000},"page":"2010-2018","source":"Crossref","is-referenced-by-count":36,"title":["Novel Benzothiazolin-2-one and Benzoxazin-3-one Arylpiperazine Derivatives with Mixed 5HT<sub>1A<\/sub>\/D<sub>2<\/sub>Affinity as Potential Atypical Antipsychotics"],"prefix":"10.1021","volume":"41","author":[{"given":"Thierry","family":"Taverne","sequence":"first","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ousmane","family":"Diouf","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Depreux","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques H.","family":"Poupaert","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lesieur","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Guardiola-Lema\u00eetre","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Renard","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claire","family":"Rettori","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel-Henri","family":"Caignard","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille Cedex, France, Ecole de Pharmacie, Universit\u00e9 Catholique de Louvain, Avenue E. Mounier 73, B-1200 Bruxelles, Belgium, and ADIR et Cie, 1 rue Carle Hebert, F-92415 Courbevoie Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[1998,5,15]]},"reference":[{"key":"jm970298cb00001\/jm970298cb00001_1","first-page":"361","volume-title":"Handbook of neurochemistry","author":"Leysen J. E.","year":"1985"},{"key":"jm970298cb00002\/jm970298cb00002_1","first-page":"593","volume":"46","author":"Kane J. M","year":"1993","journal-title":"Drugs"},{"key":"jm970298cb00003\/jm970298cb00003_1","first-page":"486","volume":"11","author":"Crow J. J","year":"1985","journal-title":"Schizophrenia Bull."},{"key":"jm970298cb00004\/jm970298cb00004_1","first-page":"9","volume":"280","author":"Cro T. J","year":"1980","journal-title":"Br. Med. J."},{"key":"jm970298cb00005\/jm970298cb00005_1","first-page":"66","volume":"6","author":"Tarsy D","year":"1983","journal-title":"Clin. Neuropharmacol."},{"key":"jm970298cb00006\/jm970298cb00006_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1001\/archpsyc.1979.01780060047005","volume":"36","author":"Shopsin B.","year":"1979","journal-title":"Arch. Gen. Psychiatry."},{"key":"jm970298cb00007\/jm970298cb00007_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0920-9964(91)90030-U","volume":"4","author":"Deutch A. Y.","year":"1991","journal-title":"Schizophr. Res."},{"key":"jm970298cb00008\/jm970298cb00008_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/BF00442555","volume":"99","author":"Farde L.","year":"1989","journal-title":"Psychopharmacology"},{"key":"jm970298cb00009\/jm970298cb00009_1","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1007\/BF00442552","volume":"99","author":"Coward D. M.","year":"1989","journal-title":"Psychopharmacology"},{"key":"jm970298cb00010\/jm970298cb00010_1","first-page":"13","volume":"46","author":"Richelson F","year":"1985","journal-title":"J. Clin. Psychiat."},{"key":"jm970298cb00011\/jm970298cb00011_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/350619a0","volume":"350","author":"Van-Tol H. H. M.","year":"1991","journal-title":"Nature"},{"key":"jm970298cb00012\/jm970298cb00012_1","first-page":"472","volume":"182","author":"Watling K. J.","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"jm970298cb00013\/jm970298cb00013_1","first-page":"277","volume":"49","author":"Lieberman J. A.","year":"1988","journal-title":"J. Clin. Psychiat."},{"key":"jm970298cb00014\/jm970298cb00014_1","first-page":"670","volume":"247","author":"Leysen J. E.","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm970298cb00015\/jm970298cb00015_1","first-page":"93","volume":"77","author":"Fuller R. W.","year":"1992","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"jm970298cb00016\/jm970298cb00016_1","first-page":"1062","volume":"37","author":"Reitz A. L.","year":"1994","journal-title":"J. Med. Chem."},{"key":"jm970298cb00017\/jm970298cb00017_1","volume-title":"Leur pr\u00e9paration et leurs applications en th\u00e9rapeutique. French Patent 83-402267-5","author":"Lesieur D.","year":"1983"},{"key":"jm970298cb00018\/jm970298cb00018_1","first-page":"1980","volume":"1","author":"Lesieur D.","year":"2086","journal-title":"French Patent"},{"key":"jm970298cb00019\/jm970298cb00019_1","first-page":"269","volume":"41","author":"Vaccher M. P.","year":"1986","journal-title":"Il Farmaco Ed. Sci."},{"key":"jm970298cb00020\/jm970298cb00020_1","first-page":"868","volume":"40","author":"Caignard D. H.","year":"1985","journal-title":"Il Farmaco Ed. Sci."},{"key":"jm970298cb00021\/jm970298cb00021_1","first-page":"1866","volume":"34","author":"Lowe J. A.","year":"1991","journal-title":"J. Med. Chem."},{"key":"jm970298cb00022\/jm970298cb00022_1","first-page":"1971","volume":"31","author":"Glennon R. A.","year":"1988","journal-title":"J. Med. Chem."},{"key":"jm970298cb00023\/jm970298cb00023_1","first-page":"806","volume":"49","author":"Mokrosz J. L.","year":"1994","journal-title":"Pharmazie"},{"key":"jm970298cb00024\/jm970298cb00024_1","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1021\/jo00085a052","volume":"59","author":"Yous S.","year":"1994","journal-title":"J. Org. Chem."},{"key":"jm970298cb00025\/jm970298cb00025_1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0223-5234(96)88289-4","volume":"30","author":"Diouf O.","year":"1995","journal-title":"Eur. J. Med. Chem."},{"key":"jm970298cb00026\/jm970298cb00026_1","first-page":"1233","volume":"41","author":"Diouf O.","year":"1995","journal-title":"Heterocycles"},{"key":"jm970298cb00027\/jm970298cb00027_1","first-page":"2125","volume":"32","author":"Moussavi Z.","year":"1991","journal-title":"Heterocycles"},{"key":"jm970298cb00028\/jm970298cb00028_1","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/jo00955a022","volume":"38","author":"West C. T.","year":"1973","journal-title":"J. Org. Chem."},{"key":"jm970298cb00029\/jm970298cb00029_1","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1021\/jm00112a043","volume":"34","author":"Raghupathi R. K.","year":"1991","journal-title":"J. Med. Chem."},{"key":"jm970298cb00030\/jm970298cb00030_1","first-page":"23","volume":"118","author":"Hoyer D.","year":"1985","journal-title":"Eur. J. Pharmacol."},{"key":"jm970298cb00031\/jm970298cb00031_1","first-page":"3108","volume":"22","author":"Cheng Y. C.","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"jm970298cb00032\/jm970298cb00032_1","first-page":"540","volume":"47","author":"Peroutka S. J","year":"1986","journal-title":"J. Neurochem."},{"key":"jm970298cb00033\/jm970298cb00033_1","first-page":"314","volume":"21","author":"Leysen J. E.","year":"1982","journal-title":"Mol. Pharmacol."},{"key":"jm970298cb00034\/jm970298cb00034_1","first-page":"173","volume":"247","author":"Sanders-Busch E.","year":"1988","journal-title":"J. Pharmacol. Exp."},{"key":"jm970298cb00035\/jm970298cb00035_1","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/0006-2952(85)90778-6","volume":"34","author":"K\u00f6hler C.","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"jm970298cb00036\/jm970298cb00036_1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/0006-2952(90)90350-T","volume":"40","author":"Reader T. A.","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"jm970298cb00037\/jm970298cb00037_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0014-2999(89)90178-7","volume":"161","author":"Arnt J.","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"jm970298cb00038\/jm970298cb00038_1","first-page":"230","volume":"316","author":"Ostmann R.","year":"1981","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"jm970298cb00039\/jm970298cb00039_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00433508","volume":"75","author":"Puech A. J.","year":"1981","journal-title":"Psychopharmacology"},{"key":"jm970298cb00040\/jm970298cb00040_1","first-page":"7","volume":"317","author":"Docherty J. R.","year":"1981","journal-title":"Pharmacol."},{"key":"jm970298cb00041\/jm970298cb00041_1","first-page":"330","volume":"143","author":"Van Rossum J. M","year":"1963","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"jm970298cb00042\/jm970298cb00042_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0006-8993(77)90645-X","volume":"123","author":"Costall B.","year":"1977","journal-title":"Brain Res."},{"key":"jm970298cb00043\/jm970298cb00043_1","first-page":"252","volume":"13","author":"Simon P.","year":"1982","journal-title":"J. Pharmacol. (Paris)"},{"key":"jm970298cb00044\/jm970298cb00044_1","first-page":"17A","volume":"122","author":"Deegan J.F.","year":"1958","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm970298cb00045\/jm970298cb00045_1","first-page":"671","volume":"11","author":"Stern L.","year":"1987","journal-title":"Prog. Neurol. Psychopharmacol. Biol. Psychiatry"},{"key":"jm970298cb00046\/jm970298cb00046_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1600-0773.1982.tb01032.x","volume":"51","author":"Arnt J","year":"1982","journal-title":"Acta Pharmacol. Toxicol."},{"key":"jm970298cb00047\/jm970298cb00047_1","first-page":"15","volume":"1","author":"Snyder S. H.","year":"1989","journal-title":"J. Neuropsychiatry"},{"key":"jm970298cb00048\/jm970298cb00048_1","first-page":"496","volume":"6","author":"Chermat R.","year":"1977","journal-title":"J. Pharmacol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm970298c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T02:19:35Z","timestamp":1704248375000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm970298c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5,15]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1998,6,1]]}},"alternative-id":["10.1021\/jm970298c"],"URL":"https:\/\/doi.org\/10.1021\/jm970298c","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5,15]]}}}